Search Results - "Lim, Young H."

GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation by Lim, Young H., Bacchiocchi, Antonella, Qiu, Jingyao, Straub, Robert, Bruckner, Anna, Bercovitch, Lionel, Narayan, Deepak, McNiff, Jennifer, Ko, Christine, Robinson-Bostom, Leslie, Antaya, Richard, Halaban, Ruth, Choate, Keith A.

“…Vascular tumors are among the most common neoplasms in infants and children; 5%–10% of newborns present with or develop lesions within the first 3 months of…”
Get full text

Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy by Atzmony, Lihi, Lim, Young H., Hamilton, Claire, Leventhal, Jonathan S., Wagner, Annette, Paller, Amy S., Choate, Keith A.

“…Porokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. We hypothesized that topical…”
Get full text

Genotype-Guided Medical Treatment of an Arteriovenous Malformation in a Child by Lekwuttikarn, Ramrada, Lim, Young H, Admani, Shehla, Choate, Keith A, Teng, Joyce M C

Get more information

Second-Hit, Postzygotic PMVK and MVD Mutations in Linear Porokeratosis by Atzmony, Lihi, Khan, Habib M, Lim, Young H, Paller, Amy S, Levinsohn, Jonathan L, Holland, Kristen E, Mirza, Fatima Nadeem, Yin, Emily, Ko, Christine J, Leventhal, Jonathan S, Choate, Keith A

“…Linear porokeratosis features linear and whorled configurations of keratotic papules and plaques, with coronoid lamellae present on histologic examination…”
Get more information

Preparation and in Vitro Antimicrobial Activity of Silver-Bearing Degradable Polymeric Nanoparticles of Polyphosphoester-block-Poly(l‑lactide) by Lim, Young H, Tiemann, Kristin M, Heo, Gyu Seong, Wagers, Patrick O, Rezenom, Yohannes H, Zhang, Shiyi, Zhang, Fuwu, Youngs, Wiley J, Hunstad, David A, Wooley, Karen L

“…The development of well-defined polymeric nanoparticles (NPs) as delivery carriers for antimicrobials targeting human infectious diseases requires rational…”
Get full text

Functional Polycarbonate of a d‑Glucal-Derived Bicyclic Carbonate via Organocatalytic Ring-Opening Polymerization by Lonnecker, Alexander T, Lim, Young H, Wooley, Karen L

“…Herein, we demonstrate the synthesis of a bicyclic carbonate monomer of a d-glucal derivative, which originated from the natural product d-glucose, in an…”
Get full text

Recessive Mutations in AP1B1 Cause Ichthyosis, Deafness, and Photophobia by Boyden, Lynn M., Atzmony, Lihi, Hamilton, Claire, Zhou, Jing, Lim, Young H., Hu, Ronghua, Pappas, John, Rabin, Rachel, Ekstien, Joseph, Hirsch, Yoel, Prendiville, Julie, Lifton, Richard P., Ferguson, Shawn, Choate, Keith A.

“…We describe unrelated individuals with ichthyosis, failure to thrive, thrombocytopenia, photophobia, and progressive hearing loss. Each have bi-allelic…”
Get full text

Development of a Vinyl Ether-Functionalized Polyphosphoester as a Template for Multiple Postpolymerization Conjugation Chemistries and Study of Core Degradable Polymeric Nanoparticles by Lim, Young H, Heo, Gyu Seong, Rezenom, Yohannes H, Pollack, Stephanie, Raymond, Jeffery E, Elsabahy, Mahmoud, Wooley, Karen L

“…A novel polyphosphoester (PPE) with vinyl ether side chain functionality was developed as a versatile template for postpolymerization modifications, and its…”
Get full text

Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia by Lim, Young H, Ovejero, Diana, Sugarman, Jeffrey S, Deklotz, Cynthia M C, Maruri, Ann, Eichenfield, Lawrence F, Kelley, Patrick K, Jüppner, Harald, Gottschalk, Michael, Tifft, Cynthia J, Gafni, Rachel I, Boyce, Alison M, Cowen, Edward W, Bhattacharyya, Nisan, Guthrie, Lori C, Gahl, William A, Golas, Gretchen, Loring, Erin C, Overton, John D, Mane, Shrikant M, Lifton, Richard P, Levy, Moise L, Collins, Michael T, Choate, Keith A

“…Pathologically elevated serum levels of fibroblast growth factor-23 (FGF23), a bone-derived hormone that regulates phosphorus homeostasis, result in renal…”
Get full text

Four Different Regioisomeric Polycarbonates Derived from One Natural Product, d‑Glucose by Lonnecker, Alexander T, Lim, Young H, Felder, Simcha E, Besset, Céline J, Wooley, Karen L

“…Strategies for the preparation of polycarbonates, derived from the natural product d-glucose, which have the potential to degrade back into their bioresorbable…”
Get full text

Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles by Elsabahy, Mahmoud, Zhang, Shiyi, Zhang, Fuwu, Deng, Zhou J., Lim, Young H., Wang, Hai, Parsamian, Perouza, Hammond, Paula T., Wooley, Karen L.

“…The construction of nanostructures from biodegradable precursors and shell/core crosslinking have been pursued as strategies to solve the problems of toxicity…”
Get full text

Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy by Lim, Young H, Odell, Ian D, Ko, Christine J, Choate, Keith A

“…Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug…”
Get more information

Assembling a protein-protein interaction map of the SSU processome from existing datasets by Lim, Young H, Charette, J Michael, Baserga, Susan J

“…The small subunit (SSU) processome is a large ribonucleoprotein complex involved in small ribosomal subunit assembly. It consists of the U3 snoRNA and ∼72…”
Get full text

Mosaicism in Cutaneous Disorders by Lim, Young H, Moscato, Zoe, Choate, Keith A

“…Genetic mosaicism arises when a zygote harbors two or more distinct genotypes, typically due to de novo , somatic mutation during embryogenesis. The clinical…”
Get full text

Retrospective Analysis of US Litigations Involving Dermatologists From 2011 to 2022 by Lim, Young H, Saberi, Shahin A, Kamal, Kanika, Jalian, H Ray, Avram, Mathew

“…Physician malpractice lawsuits are climbing, and the reasons underlying litigation against dermatologists are unclear. To determine the reasons patients pursue…”
Get full text

Polymeric nanoparticles in development for treatment of pulmonary infectious diseases by Lim, Young H., Tiemann, Kristin M., Hunstad, David A., Elsabahy, Mahmoud, Wooley, Karen L.

“…Serious lung infections, such as pneumonia, tuberculosis, and chronic obstructive cystic fibrosis‐related bacterial diseases, are increasingly difficult to…”
Get full text

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy by Lim, Young H., Ovejero, Diana, Derrick, Kristina M., Collins, Michael T., Choate, Keith A.

“…We recently demonstrated multilineage somatic mosaicism in cutaneous skeletal hypophosphatemia syndrome (CSHS), which features epidermal or melanocytic nevi,…”
Get full text

Revertant mosaicism in genodermatoses by Lim, Young H., Fisher, Jonathan M., Choate, Keith A.

“…Inherited monogenic skin disorders include blistering disorders, inflammatory disorders, and disorders of differentiation or development. In most cases, the…”
Get full text

Somatic Activating RAS Mutations Cause Vascular Tumors Including Pyogenic Granuloma by Lim, Young H., Douglas, Stephanie R., Ko, Christine J., Antaya, Richard J., McNiff, Jennifer M., Zhou, Jing, Choate, Keith A., Narayan, Deepak

Get full text

Expanding the Mutation Spectrum of Ichthyosis with Confetti by Lim, Young H., Choate, Keith A.

“…Ichthyosis with confetti is a rare, autosomal dominant disorder caused by frameshift mutations in KRT10 or KRT1 and characterized by the development of white,…”
Get full text