Search Results - "Lim, Yi Chieh"

Salinomycin-Loaded Gold Nanoparticles for Treating Cancer Stem Cells by Ferroptosis-Induced Cell Death by Zhao, Yongmei, Zhao, Wei, Lim, Yi Chieh, Liu, Tianqing

“…Cancer stem cells (CSCs) are a subpopulation of tumor cells that exhibit self-renewal, differentiation, and tumorigenicity. CSCs are highly resistant to the…”
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Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci by Lim, Yi Chieh

“…Visual inspection of cellular activities based on conventional fluorescence microscope is a fundamental tool to study the role of DNA damage response (DDR). In…”
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A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma by Stringer, Brett W., Day, Bryan W., D’Souza, Rochelle C. J., Jamieson, Paul R., Ensbey, Kathleen S., Bruce, Zara C., Lim, Yi Chieh, Goasdoué, Kate, Offenhäuser, Carolin, Akgül, Seçkin, Allan, Suzanne, Robertson, Thomas, Lucas, Peter, Tollesson, Gert, Campbell, Scott, Winter, Craig, Do, Hongdo, Dobrovic, Alexander, Inglis, Po-Ling, Jeffree, Rosalind L., Johns, Terrance G., Boyd, Andrew W.

“…Low-passage, serum-free cell lines cultured from patient tumour tissue are the gold-standard for preclinical studies and cellular investigations of…”
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ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression by Quek, Hazel, Cuní-López, Carla, Stewart, Romal, Colletti, Tiziana, Notaro, Antonietta, Nguyen, Tam Hong, Sun, Yifan, Guo, Christine C, Lupton, Michelle K, Roberts, Tara L, Lim, Yi Chieh, Oikari, Lotta E, La Bella, Vincenzo, White, Anthony R

“…Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing…”
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A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype by Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C, Noakes, Peter G, Lim, Yi Chieh, Barnett, Nigel L, Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L, Lavin, Martin F

“…Ataxia-telangiectasia (A-T), an autosomal recessive disease caused by mutations in the ATM gene is characterised by cerebellar atrophy and progressive…”
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EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme by Day, Bryan W., Stringer, Brett W., Al-Ejeh, Fares, Ting, Michael J., Wilson, John, Ensbey, Kathleen S., Jamieson, Paul R., Bruce, Zara C., Lim, Yi Chieh, Offenhäuser, Carolin, Charmsaz, Sara, Cooper, Leanne T., Ellacott, Jennifer K., Harding, Angus, Leveque, Lucie, Inglis, Po, Allan, Suzanne, Walker, David G., Lackmann, Martin, Osborne, Geoffrey, Khanna, Kum Kum, Reynolds, Brent A., Lickliter, Jason D., Boyd, Andrew W.

“…Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show…”
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage by Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropée, Romain, Patch, Ann-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen, Shu W., Day, Bryan, Möller, Andreas, Cloonan, Nicole, Pearson, John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E., Edwards, Stacey L., French, Juliet D.

“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
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Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial-Mesenchymal Transition by Zhao, Yongmei, Wang, Kaikai, Zheng, Yuanlin, Zeng, Xiaobao, Lim, Yi Chieh, Liu, Tianqing

“…Malignant cancer is a devastating disease often associated with a poor clinical prognosis. For decades, modern drug discoveries have attempted to identify…”
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells by Obara, Elisabeth Anne Adanma, Aguilar-Morante, Diana, Rasmussen, Rikke Darling, Frias, Alex, Vitting-Serup, Kristoffer, Lim, Yi Chieh, Elbæk, Kirstine Juul, Pedersen, Henriette, Vardouli, Lina, Jensen, Kamilla Ellermann, Skjoth-Rasmussen, Jane, Brennum, Jannick, Tuckova, Lucie, Strauss, Robert, Dinant, Christoffel, Bartek, Jiri, Hamerlik, Petra

“…Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms…”
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The dystroglycan receptor maintains glioma stem cells in the vascular niche by Day, Bryan W., Lathia, Justin D., Bruce, Zara C., D’Souza, Rochelle C. J., Baumgartner, Ulrich, Ensbey, Kathleen S., Lim, Yi Chieh, Stringer, Brett W., Akgül, Seçkin, Offenhäuser, Carolin, Li, Yuchen, Jamieson, Paul R., Smith, Fiona M., Jurd, Courtney L. R., Robertson, Thomas, Inglis, Po-Ling, Lwin, Zarnie, Jeffree, Rosalind L., Johns, Terrance G., Bhat, Krishna P. L., Rich, Jeremy N., Campbell, Kevin P., Boyd, Andrew W.

“…Glioblastomas (GBMs) are malignant central nervous system (CNS) neoplasms with a very poor prognosis. They display cellular hierarchies containing…”
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In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair by Remali, Juwairiah, Aizat, Wan Mohd, Ng, Chyan Leong, Lim, Yi Chieh, Mohamed-Hussein, Zeti-Azura, Fazry, Shazrul

“…DNA double strand break repair is important to preserve the fidelity of our genetic makeup after DNA damage. Rad50 is one of the components in MRN complex…”
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A robust approach to differentiate human monocyte-derived microglia from peripheral blood mononuclear cells by Quek, Hazel, Cuní-López, Carla, Stewart, Romal, Lim, Yi Chieh, Roberts, Tara L., White, Anthony R.

“…Microglia are implicated in most neurodegenerative diseases. Here, we present a robust and efficient protocol to differentiate monocyte-derived microglia-like…”
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Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein by Bang-Christensen, Sara R, Pedersen, Rasmus S, Pereira, Marina A, Clausen, Thomas M, Løppke, Caroline, Sand, Nicolai T, Ahrens, Theresa D, Jørgensen, Amalie M, Lim, Yi Chieh, Goksøyr, Louise, Choudhary, Swati, Gustavsson, Tobias, Dagil, Robert, Daugaard, Mads, Sander, Adam F, Torp, Mathias H, Søgaard, Max, Theander, Thor G, Østrup, Olga, Lassen, Ulrik, Hamerlik, Petra, Salanti, Ali, Agerbæk, Mette Ø

“…Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases are rarely observed, recent studies have shown the presence…”
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AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation by Cullen, Jason K, Abdul Murad, Norazian, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L, Parton, Robert G, Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J, Stocker, Roland, Lavin, Martin F

“…Autosomal recessive ataxias are a clinically diverse group of syndromes that in some cases are caused by mutations in genes with roles in the DNA damage…”
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Editorial: Cancer Therapeutics: Targeting DNA Repair Pathways by Suraweera, Amila, Brown, James A L, Lim, Yi Chieh, Lavin, Martin F

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Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma by Aguilar-Morante, Diana, Gómez-Cabello, Daniel, Quek, Hazel, Liu, Tianqing, Hamerlik, Petra, Lim, Yi Chieh

“…Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires…”
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Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade by Cullen, Jason K, Yap, Pei-Yi, Ferguson, Blake, Bruce, Zara C, Koyama, Motoko, Handoko, Herlina, Hendrawan, Kevin, Simmons, Jacinta L, Brooks, Kelly M, Johns, Jenny, Wilson, Emily S, de Souza, Marjorie M A, Broit, Natasa, Stewart, Praphaporn, Shelley, Daniel, McMahon, Tracey, Ogbourne, Steven M, Nguyen, Tam Hong, Lim, Yi Chieh, Pagani, Alberto, Appendino, Giovanni, Gordon, Victoria A, Reddell, Paul W, Boyle, Glen M, Parsons, Peter G

“…BackgroundTigilanol tiglate (TT) is a protein kinase C (PKC)/C1 domain activator currently being developed as an intralesional agent for the treatment of…”
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Correction: AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation by Cullen, Jason K, Abdul Murad, Norazian, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L, Parton, Robert G, Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J, Stocker, Roland, Lavin, Martin F

“…[This corrects the article DOI: 10.1371/journal.pone.0148213.]…”
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Low Dose Ionizing Radiation Responses and Knockdown of ATM Kinase Activity in Glioma Stem Cells by LIM, Yi Chieh, ROBERTS, Tara, HARDING, Angus, DAY, Bryan, KOZLOV, Sergei, WALKER, David, LAVIN, Martin

“…Genesis of new cells in the mammalian brain has previously been regarded as a negligible event; an assumption that long prevented our understanding in the…”
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Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish ( Danio rerio ) Embryos by Fazry, Shazrul, Noordin, Muhammad Akram Mohd, Sanusi, Salahuddin, Noor, Mahanem Mat, Aizat, Wan Mohd, Lazim, Azwan Mat, Dyari, Herryawan Ryadi Eziwar, Jamar, Nur Hidayah, Remali, Juwairiah, Othman, Babul Airianah, Law, Douglas, Sidik, Nik Marzuki, Cheah, Yew Hoong, Lim, Yi Chieh

“…Xanthone is an organic compound mostly found in mangosteen pericarp and widely known for its anti-proliferating effect on cancer cells. In this study, we…”
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