Search Results - "Lim, Teck Kwang"
-
1
Proteomic Characterisation of the Salt Gland-Enriched Tissues of the Mangrove Tree Species Avicennia officinalis
Published in PloS one (20-07-2015)“…Plant salt glands are nature's desalination devices that harbour potentially useful information pertaining to salt and water transport during secretion. As…”
Get full text
Journal Article -
2
Cytotoxic mechanisms of panduratin A on A375 melanoma cells: A quantitative and temporal proteomics analysis
Published in Proteomics (Weinheim) (01-05-2015)“…Melanoma is a lethal form of skin cancer with rising global incidence. However, limited treatment options are available for advanced melanoma and this is…”
Get full text
Journal Article -
3
Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells
Published in Journal of bioscience and bioengineering (01-03-2013)“…We have evaluated the effect of heart extracellular matrix (ECM) on the cardiomyocyte differentiation of mouse embryonic stem cells (ES cells) using…”
Get full text
Journal Article -
4
Proteomic analysis of Singapore grouper iridovirus envelope proteins and characterization of a novel envelope protein VP088
Published in Proteomics (Weinheim) (01-06-2011)“…Singapore grouper iridovirus (SGIV) is an enveloped virus causing heavy economic losses to marine fish culture. The envelope fractions of SGIV were separated…”
Get full text
Journal Article -
5
Proteome profile of salt gland-rich epidermis extracted from a salt-tolerant tree species
Published in Electrophoresis (01-10-2015)“…Preparation of proteins from salt‐gland‐rich tissues of mangrove plant is necessary for a systematic study of proteins involved in the plant's unique…”
Get full text
Journal Article -
6
White Spot Syndrome Virus Proteins and Differentially Expressed Host Proteins Identified in Shrimp Epithelium by Shotgun Proteomics and Cleavable Isotope-Coded Affinity Tag
Published in Journal of Virology (01-11-2007)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
7
Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity
Published in Angewandte Chemie International Edition (24-10-2016)“…Understanding the mechanism of action (MOA) of bioactive natural products will guide endeavor to improve their cellular activities. Artemisinin and its…”
Get full text
Journal Article -
8
Differential recovery of membrane proteins after extraction by aqueous methanol and trifluoroethanol
Published in Proteomics (Weinheim) (01-05-2007)“…Cell membrane proteome analysis is limited by inherent membrane hydrophobicity. Conventional membrane protein extraction techniques use detergents, chaotropes…”
Get full text
Journal Article -
9
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
Published in Nature communications (22-12-2015)“…The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an…”
Get full text
Journal Article -
10
Quantitative Proteomics of Strong and Weak Biofilm Formers of Enterococcus faecalis Reveals Novel Regulators of Biofilm Formation
Published in Molecular & cellular proteomics (01-04-2018)“…Enterococcus faecalis is a bacterial pathogen associated with both endodontic and systemic infections. The biofilm formation ability of E. faecalis plays a key…”
Get full text
Journal Article -
11
Pyrazinamide triggers degradation of its target aspartate decarboxylase
Published in Nature communications (03-04-2020)“…Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the…”
Get full text
Journal Article -
12
Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway
Published in Molecules (Basel, Switzerland) (08-08-2017)“…The artemisinin compounds, which are well-known for their potent therapeutic antimalarial activity, possess in vivo and in vitro antitumor effects. Although…”
Get full text
Journal Article -
13
SARS-CoV-2 Spike Protein and Mouse Coronavirus Inhibit Biofilm Formation by Streptococcus pneumoniae and Staphylococcus aureus
Published in International journal of molecular sciences (18-03-2022)“…The presence of co-infections or superinfections with bacterial pathogens in COVID-19 patients is associated with poor outcomes, including increased morbidity…”
Get full text
Journal Article -
14
Quantitative proteome profiles help reveal efficient xylose utilization mechanisms in solventogenic Clostridium sp. strain BOH3
Published in Biotechnology and bioengineering (01-09-2017)“…ABSTRACT Development of sustainable biobutanol production platforms from lignocellulosic materials is impeded by inefficient five carbon sugar uptake by…”
Get full text
Journal Article -
15
Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)
Published in Scientific reports (12-04-2018)“…Molecules of single proteins, echoforms, can be distributed between two (or more) subcellular locations, a phenomenon which we refer to as dual targeting or…”
Get full text
Journal Article -
16
Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity
Published in ACS central science (26-07-2017)“…The antimalarial artemisinin (ART) possesses anticancer activity, but its underlying mechanism remains largely unclear. Using a chemical proteomics approach…”
Get full text
Journal Article -
17
Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes
Published in Scientific reports (21-03-2017)“…RNA-binding protein Rbm24 is a key regulator of heart development and required for sarcomere assembly and heart contractility. Yet, its underlying mechanism…”
Get full text
Journal Article -
18
Proteomic analysis of ceftazidime and meropenem-exposed Pseudomonas aeruginosa ATCC 9027
Published in Proteome science (28-09-2023)“…Abstract Background Pseudomonas aeruginosa is well known for its intrinsic ability to resist a wide range of antibiotics, thus complicates treatment. Thus,…”
Get full text
Journal Article -
19
Identification of Key Players for Colorectal Cancer Metastasis by iTRAQ Quantitative Proteomics Profiling of Isogenic SW480 and SW620 Cell Lines
Published in Journal of proteome research (07-10-2011)“…This study compared the whole cell proteome profiles of two isogenic colorectal cancer (CRC) cell lines (primary SW480 cell line and its lymph node metastatic…”
Get full text
Journal Article -
20
Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake
Published in Molecules (Basel, Switzerland) (31-08-2017)“…: Andrographolide (ADR), the main active component of , displays anticancer activity in various cancer cell lines, among which leukemia cell lines exhibit the…”
Get full text
Journal Article