Search Results - "Lim, Shiang"

Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications by Chan, Elsa C, Kuo, Shyh-Ming, Kong, Anne M, Morrison, Wayne A, Dusting, Gregory J, Mitchell, Geraldine M, Lim, Shiang Y, Liu, Guei-Sheung

“…Here, we describe a porous 3-dimensional collagen scaffold material that supports capillary formation in vitro, and promotes vascularization when implanted in…”
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Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury by ONG, Sang-Bing, SUBRAYAN, Sapna, LIM, Shiang Y, YELLON, Derek M, DAVIDSON, Sean M, HAUSENLOY, Derek J

“…Whether alterations in mitochondrial morphology affect the susceptibility of the heart to ischemia/reperfusion injury is unknown. We hypothesized that…”
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Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy by Phang, Ren Jie, Ritchie, Rebecca H, Hausenloy, Derek J, Lees, Jarmon G, Lim, Shiang Y

“…Abstract Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac phenotype known as diabetic cardiomyopathy. Cardiac…”
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Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart by Prakoso, Darnel, Lim, Shiang Y, Erickson, Jeffrey R, Wallace, Rachel S, Lees, Jarmon G, Tate, Mitchel, Kiriazis, Helen, Donner, Daniel G, Henstridge, Darren C, Davey, Jonathan R, Qian, Hongwei, Deo, Minh, Parry, Laura J, Davidoff, Amy J, Gregorevic, Paul, Chatham, John C, De Blasio, Miles J, Ritchie, Rebecca H

“…Abstract Aims  The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is increased in…”
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A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly by Lyu, Quanxia, Gong, Shu, Lees, Jarmon G., Yin, Jialiang, Yap, Lim Wei, Kong, Anne M., Shi, Qianqian, Fu, Runfang, Zhu, Qiang, Dyer, Ash, Dyson, Jennifer M., Lim, Shiang Y., Cheng, Wenlong

“…Time-lapse mechanical properties of stem cell derived cardiac organoids are important biological cues for understanding contraction dynamics of human heart…”
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The neural and humoral pathways in remote limb ischemic preconditioning by Lim, Shiang Y., Yellon, Derek M., Hausenloy, Derek J.

“…Remote ischaemic preconditioning (RIPC) is a therapeutic intervention that has been demonstrated to reduce myocardial injury in the clinical setting. However,…”
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Cellular pathophysiology of Friedreich's ataxia cardiomyopathy by Lees, Jarmon G., Napierala, Marek, Pébay, Alice, Dottori, Mirella, Lim, Shiang Y.

“…Friedreich's ataxia (FRDA) is a hereditary neuromuscular disorder. Cardiomyopathy is the leading cause of premature death in FRDA. FRDA cardiomyopathy is a…”
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Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair by Lozano, Jonathan, Rai, Alin, Lees, Jarmon G, Fang, Haoyun, Claridge, Bethany, Lim, Shiang Y, Greening, David W

“…Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to repair injured cardiac tissues and regulate pathological fibrosis…”
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HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore by Ong, Sang-Ging, Lee, Won Hee, Theodorou, Louise, Kodo, Kazuki, Lim, Shiang Y, Shukla, Deepa H, Briston, Thomas, Kiriakidis, Serafim, Ashcroft, Margaret, Davidson, Sean M, Maxwell, Patrick H, Yellon, Derek M, Hausenloy, Derek J

“…Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tolerance against acute myocardial ischaemia-reperfusion injury (IRI). However, the mechanism…”
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Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission by Kalkhoran, Siavash Beikoghli, Kriston-Vizi, Janos, Hernandez-Resendiz, Sauri, Crespo-Avilan, Gustavo E, Rosdah, Ayeshah A, Lees, Jarmon G, Costa, Joana Rodrigues Simoes Da, Ling, Naomi X Y, Holien, Jessica K, Samangouei, Parisa, Chinda, Kroekkiat, Yap, En Ping, Riquelme, Jaime A, Ketteler, Robin, Yellon, Derek M, Lim, Shiang Y, Hausenloy, Derek J

“…Abstract Aims Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IRI) has been shown to…”
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New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology by Rosdah, Ayeshah A., Smiles, William J., Oakhill, Jonathan S., Scott, John W., Langendorf, Christopher G., Delbridge, Lea M.D., Holien, Jessica K., Lim, Shiang Y.

“…Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochondrial fusion and fission is…”
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Real-time electro-mechanical profiling of dynamically beating human cardiac organoids by coupling resistive skins with microelectrode arrays by Yin, Jialiang, Lees, Jarmon G., Gong, Shu, Nguyen, John Tan, Phang, Ren Jie, Shi, Qianqian, Huang, Yifeng, Kong, Anne M., Dyson, Jennifer M., Lim, Shiang Y., Cheng, Wenlong

“…Cardiac organoids differentiated from induced pluripotent stem cells are emerging as a promising platform for pre-clinical drug screening, assessing…”
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Omaveloxolone for the Treatment of Friedreich Ataxia: Efficacy, Safety, and Future Perspectives by Naghipour, Saba, Corben, Louise A., Hulme, Amy J., Dottori, Mirella, Delatycki, Martin B., Lees, Jarmon G., Lim, Shiang Y.

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Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction by Kompa, Andrew R, Greening, David W, Kong, Anne M, McMillan, Paul J, Fang, Haoyun, Saxena, Ritika, Wong, Raymond C B, Lees, Jarmon G, Sivakumaran, Priyadharshini, Newcomb, Andrew E, Tannous, Bakhos A, Kos, Cameron, Mariana, Lina, Loudovaris, Thomas, Hausenloy, Derek J, Lim, Shiang Y

“…Abstract Aims To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be…”
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A novel small molecule inhibitor of human Drp1 by Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.

“…Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous…”
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Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells by Hsiao, Sarah T, Lokmic, Zerina, Peshavariya, Hitesh, Abberton, Keren M, Dusting, Gregory J, Lim, Shiang Y, Dilley, Rodney J

“…Human adipose-derived stem cells (ASCs) secrete cytokines and growth factors that can be harnessed in a paracrine fashion for promotion of angiogenesis, cell…”
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Community priorities for obesity prevention among low-income adults in Kuala Lumpur: a discrete choice experiment by Kocher, Erica, Wood, Dallas, Lim, Shiang-Cheng, Jackson-Morris, Angie, Kataria, Ishu, Ngongo, Carrie, Sham, Zhi, Chandran, Arunah, Nugent, Rachel, Mustapha, Feisul Idzwan

“…Non-communicable diseases and associated risk factors, such as obesity, are prevalent and increasing in Malaysia. To address this burden and the heightened…”
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Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle by Kong, Anne M., Yap, Kiryu K., Lim, Shiang Y., Marre, Diego, Pébay, Alice, Gerrand, Yi-wen, Lees, Jarmon G., Palmer, Jason A., Morrison, Wayne A., Mitchell, Geraldine M

“…[Display omitted] Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a tissue flap…”
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Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment by Bandara, Nadeeka, Gurusinghe, Saliya, Kong, Anne, Mitchell, Geraldine, Wang, Le‐Xin, Lim, Shiang Y., Strappe, Padraig

“…Enhancing differentiation of mesenchymal stem cells (MSCs) to endothelial cells may improve their ability to vascularize tissue and promote wound healing. This…”
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Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology by Deng, Yali, Ngo, Doan T. M., Holien, Jessica K., Lees, Jarmon G., Lim, Shiang Y.

“…Purpose of Review This study is aimed at reviewing the recent progress in Drp1 inhibition as a novel approach for reducing doxorubicin-induced cardiotoxicity…”
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