Search Results - "Lim, Sheau Chin"

Curcumin and a hemi‐analogue with improved blood–brain barrier permeability protect against amyloid‐beta toxicity in Caenorhabditis elegans via SKN‐1/Nrf activation by Lee, Elaine Hui‐Chien, Lim, Sherlyn Sheau‐Chin, Yuen, Kah‐Hay, Lee, Chong‐Yew

“…Objectives This study aims to investigate the blood–brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect…”
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Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients by Amin, Arwa M., Sheau Chin, Lim, Teh, Chin-Hoe, Mostafa, Hamza, Mohamed Noor, Dzul Azri, Abdul Kader, Muhamad Ali S.K., Kah Hay, Yuen, Ibrahim, Baharudin

“…Dual antiplatelet therapy (DAPT) of clopidogrel and aspirin is crucial for coronary artery disease (CAD) patients undergoing percutaneous coronary intervention…”
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The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics by Kah Hay, Yuen, SK Abdul Kader, Muhamad Ali, Azri Mohamed Noor, Dzul, Sheau Chin, Lim, Amin, Arwa M., Ibrahim, Baharudin

“…Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention. However, the variable platelets…”
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Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily Liquid Tocotrienols as Model Active Substance by Lee, You Zhuan, Seow, Eng Kwong, Lim, Sheau Chin, Yuen, Kah Hay, Abdul Karim Khan, Nurzalina

“…Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems…”
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The effect of CYP2C19 genetic polymorphism and non-genetic factors on clopidogrel platelets inhibition in East Asian coronary artery disease patients by Amin, Arwa M., Sheau Chin, Lim, Mohamed Noor, Dzul Azri, Mostafa, Hamza, Abdul Kader, Muhamad Ali S.K., Kah Hay, Yuen, Ibrahim, Baharudin

“…[Display omitted] •Clopidogrel HTPR is frequent among East Asians, regardless of using high LD.•CYP2C19*2 and obesity are associated with clopidogrel HTPR,…”
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1H NMR based pharmacometabolomics analysis of urine identifies metabolic phenotype of clopidogrel high on treatment platelets reactivity in coronary artery disease patients by Amin, Arwa M., Sheau Chin, Lim, Teh, Chin-Hoe, Mostafa, Hamza, Mohamed Noor, Dzul Azri, SK Abdul Kader, Muhamad Ali, Kah Hay, Yuen, Ibrahim, Baharudin

“…[Display omitted] •We analysed patients’ urine samples before and after the administration of 600mg clopidogrel loading dose using 1H NMR.•Multivariate…”
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TCT-841 Integrative Pharmacometabonomics-Pharmacogenetics approach to predict clopidogrel response in Coronary Artery Disease (CAD) patients undergoing Interventional Angiographic Procedure (IAP) by Amin Mostafa, Arwa M., Chin, Lim Sheau, Mohamed Noor, Dzul Azri, Amin Mostafa, Hamza Mohamed, Ali SK Abdul Kader, Muhamad, Hay, Yuen Kah, Ibrahim, Baharudin

“…Nuclear magnetic resonance spectroscopy (NMR) pharmacometabonomics analysis has been used to predict drug response. Methods 71 coronary artery disease (CAD)…”
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The CYP2C191/2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers by Sheau Chin, Lim, Mohd Redhuan Shah Edwin, Nur Elyana Yazmin, Nasyuhana Sani, Yanti, Kah Hay, Yuen, Serebruany, Victor L., Teck Hwa, Goh, Luen Hui, Lim

“…Background. The CYP2C19*2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19*2 alleles correlate…”
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The CYP2C19(∗)1/(∗)2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers by Nasyuhana Sani, Yanti, Sheau Chin, Lim, Luen Hui, Lim, Mohd Redhuan Shah Edwin, Nur Elyana Yazmin, Teck Hwa, Goh, Serebruany, Victor L, Kah Hay, Yuen

“…Background. The CYP2C19∗2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19∗2 alleles correlate…”
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Formulation of oily tocotrienols as a solid self-emulsifying dosage form for improved oral bioavailability in human subjects by Lee, You Zhuan, Seow, Eng Kwong, Lim, Sheau Chin, Yuen, Kah Hay, Khan, Nurzalina Abdul Karim

“…Self-emulsifying drug delivery systems (SEDDS) have been shown to enhance the water-solubility and oral bioavailability of poorly water-soluble compound. Solid…”
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Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial by Hor, Chee Peng, Fung, Wai Yee, Ang, Hock Aun, Lim, Sheau Chin, Kam, Li Ying, Sim, Su-Way, Lim, Luen Hui, Choon, Wai Yee, Wong, Jia Woei, Ch'ng, Alan Swee Hock, Beh, Kelvin Khai Meng, Wee, Hong Chin, Ong, Loke Meng, Khan, Nurzalina Abdul Karim, Sulaiman, Syed Azhar Syed, Shuaib, Ibrahim Lutfi, Bakar, Adlina, Yusof, Yusnita, Yusof, Yusmawati Mohd, Abu Bakar, Fatimah, Tang, Wei Shuong, Teh, Hoon Lang, Wahid, Normala Abdul, Saaidin, Suriani, Idris, Najihah, Yoon, Chee Kin, Ong, Hoon Ngoh, Ganapathy, Jayasumithra T, Loo, Ching Ee, Samy, Michelle M, Zainal, Hadzlinda, Dharan, Shalini C Sree, Ooi, Bee Yen, Teoh, Pei Yeing, Tye, Yi Loon, Yeoh, Chin Aun, Low, Dy Win, Looi, Irene, Yuen, Kah Hay

“…Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy…”
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Effect of Food Status on the Gastrointestinal Transit of Amphotericin B-Containing Solid Lipid Nanoparticles in Rats by Amekyeh, Hilda, Billa, Nashiru, Yuen, Kah-Hay, Lim, Sheau Chin Sherlyn

“…Amphotericin B (AmB) is poorly absorbed from the gastrointestinal tract. Recent studies have suggested enhanced drug absorption from solid lipid nanoparticles…”
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1 H NMR based pharmacometabolomics analysis of urine identifies metabolic phenotype of clopidogrel high on treatment platelets reactivity in coronary artery disease patients by Amin, Arwa M, Sheau Chin, Lim, Teh, Chin-Hoe, Mostafa, Hamza, Mohamed Noor, Dzul Azri, Sk Abdul Kader, Muhamad Ali, Kah Hay, Yuen, Ibrahim, Baharudin

“…Clopidogrel high on treatment platelets reactivity (HTPR) has burdened achieving optimum therapeutic outcome. Although there are known genetic and non-genetic…”
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TCTAP A-126 The Identification of Novel Biomarkers of Clopidogrel High on Treatment Platelets Reactivity Using Pharmacometabonomics Analysis of Plasma in Coronary Artery Disease Patients by Amin Mostafa, Arwa Mohamed, Chin, Lim Sheau, Amin Mostafa, Hamza Mohamed, Abdul Kader, Muhamad Ali S.K, Mohamed Noor, Dzul Azri, Hay, Yuen Kah, Ibrahim, Baharudin

“…Methods Blood samples of 71 coronary artery disease (CAD) patients planned for interventional angiographic procedure were collected prior to loading with…”
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A Gastrointestinal Transit Study on Amphotericin B-Loaded Solid Lipid Nanoparticles in Rats by Amekyeh, Hilda, Billa, Nashiru, Yuen, Kah-Hay, Chin, Sherlyn Lim Sheau

“…The gastrointestinal (GI) transit behavior of and absorption from an amphotericin B (AmB) solid lipid nanoformulation (SLN) in rats was investigated. We aimed…”
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PHARMACOMETABONOMICS ANALYSIS OF URINE TO PREDICT CLOPIDOGREL HIGH ON TREATMENT PLATELETS REACTIVITY (HTPR) IN CORONARY ARTERY DISEASE PATIENTS (CAD) UNDERGOING INTERVENTIONAL ANGIOGRAPHIC PROCEDURE by Mostafa, Arwa Mohamed Amin, Chin, Lim Sheau, Mostafa, Hamza Mohamed Amin, Kader, Muhamad Ali Sk Abdul, Teh, Chin-Hoe, Noor, Dzul Azri Mohamed, Hay, Yuen Kah, Ibrahim, Baharudin

“…Clopidogrel antiplatelet drug is limited by variable response among patients. This leads to poor patient outcome on treatment platelets reactivity (HTPR)…”
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PHARMACOMETABONOMICS ANALYSIS OF PLASMA TO IDENTIFY NOVEL BIOMARKERS OF CLOPIDOGREL HIGH ON TREATMENT PLATELETS REACTIVITY (HTPR) by Mostafa, Arwa Mohamed Amin, Chin, Lim Sheau, Mostafa, Hamza Mohamed Amin, Kader, Muhamad Ali Sk Abdul, Teh, Chin-Hoe, Noor, Dzul Azri Mohamed, Hay, Yuen Kah, Ibrahim, Baharudin

“…Prescribing clopidogrel antiplatelet drug is mitigated by high on treatment platelets reactivity (HTPR) which might lead to therapeutic failure. The HTPR is…”
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The [CYP2C19.sup.] [1/.sup.]2 genotype does not adequately predict clopidogrel response in healthy Malaysian volunteers by Sani, Yanti Nasyuhana, Chin, Lim Sheau, Hui, Lim Luen, Edwin, Nur Elyana Yazmin Mohd Redhuan Shah, Hwa, Goh Teck, Serebruany, Victor L, Hay, Yuen Kah

“…Background. The [CYP2C19.sup.*] 2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether [CYP2C19.sup.*] 2…”
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