Search Results - "Lim, Seon Ah"

Development of a dried blood spot sampling method towards therapeutic monitoring of radotinib in the treatment of chronic myeloid leukaemia by Lee, Jihyun, Jung, Su Young, Choi, Mi‐Yeon, Park, Ji‐su, Park, Su‐kyoung, Lim, Seon‐Ah, Cho, Kyung Hee, Oh, Soo Yeon, Ha, Jungeun, Kim, Dong‐Wook, Lee, Jangik

“…What is known and objective Dried blood spot (DBS) sampling is a minimally invasive method of blood sampling that enables monitoring of drug concentrations to…”
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Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy by Wei, Jun, Long, Lingyun, Zheng, Wenting, Dhungana, Yogesh, Lim, Seon Ah, Guy, Cliff, Wang, Yanyan, Wang, Yong-Dong, Qian, Chenxi, Xu, Beisi, KC, Anil, Saravia, Jordy, Huang, Hongling, Yu, Jiyang, Doench, John G., Geiger, Terrence L., Chi, Hongbo

“…Adoptive cell therapy represents a new paradigm in cancer immunotherapy, but it can be limited by the poor persistence and function of transferred T cells 1 …”
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Signaling networks in immunometabolism by Saravia, Jordy, Raynor, Jana L., Chapman, Nicole M., Lim, Seon Ah, Chi, Hongbo

“…Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor,…”
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CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology by Su, Wei, Saravia, Jordy, Risch, Isabel, Rankin, Sherri, Guy, Cliff, Chapman, Nicole M., Shi, Hao, Sun, Yu, KC, Anil, Li, Wei, Huang, Hongling, Lim, Seon Ah, Hu, Haoran, Wang, Yan, Liu, Danting, Jiao, Yun, Chen, Ping-Chung, Soliman, Hadeer, Yan, Koon-Kiu, Zhang, Jonathan, Vogel, Peter, Liu, Xueyan, Serrano, Geidy E., Beach, Thomas G., Yu, Jiyang, Peng, Junmin, Chi, Hongbo

“…Neurodegenerative diseases, including Alzheimer’s disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic…”
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CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity by Long, Lingyun, Wei, Jun, Lim, Seon Ah, Raynor, Jana L., Shi, Hao, Connelly, Jon P., Wang, Hong, Guy, Cliff, Xie, Boer, Chapman, Nicole M., Fu, Guotong, Wang, Yanyan, Huang, Hongling, Su, Wei, Saravia, Jordy, Risch, Isabel, Wang, Yong-Dong, Li, Yuxin, Niu, Mingming, Dhungana, Yogesh, KC, Anil, Zhou, Peipei, Vogel, Peter, Yu, Jiyang, Pruett-Miller, Shondra M., Peng, Junmin, Chi, Hongbo

“…Nutrients are emerging regulators of adaptive immunity 1 . Selective nutrients interplay with immunological signals to activate mechanistic target of rapamycin…”
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Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients by Lim, Seon Ah, Kim, Jungwon, Jeon, Seunghyun, Shin, Min Hwa, Kwon, Joonha, Kim, Tae-Jin, Im, Kyungtaek, Han, Youngmin, Kwon, Wooil, Kim, Sun-Whe, Yee, Cassian, Kim, Seong-Jin, Jang, Jin-Young, Lee, Kyung-Mi

“…Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival…”
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Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways by Lim, Seon Ah, Moon, Yunwon, Shin, Min Hwa, Kim, Tae-Jin, Chae, Sehyun, Yee, Cassian, Hwang, Daehee, Park, Hyunsung, Lee, Kyung-Mi

“…NK cells are the predominant innate lymphocyte subsets specialized to kill malignant tumor cells. In patients with advanced cancer, hypoxic stress shapes NK…”
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Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma by Kim, Jeongsoo, Kim, Tae-Jin, Chae, Sehyun, Ha, Hyojeong, Park, Yejin, Park, Sunghee, Yoon, Chul Joo, Lim, Seon Ah, Lee, Hyemin, Kim, Jiyoung, Kim, Jungwon, Im, Kyungtaek, Lee, Kyunghye, Kim, Jeongmin, Kim, Daham, Lee, Eunju, Shin, Min Hwa, Park, Serk In, Rhee, Inmoo, Jung, Keehoon, Lee, Jeewon, Lee, Keun Hwa, Hwang, Daehee, Lee, Kyung-Mi

“…In the myeloid compartment of the tumor microenvironment, CD244 signaling has been implicated in immunosuppressive phenotype of monocytes. However, the precise…”
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CD160 serves as a negative regulator of NKT cells in acute hepatic injury by Kim, Tae-Jin, Park, Gayoung, Kim, Jeongmin, Lim, Seon Ah, Kim, Jiyoung, Im, Kyungtaek, Shin, Min Hwa, Fu, Yang-Xin, Del Rio, Maria-Luisa, Rodriguez-Barbosa, Jose-Ignacio, Yee, Cassian, Suh, Kyung-Suk, Kim, Seong-Jin, Ha, Sang-Jun, Lee, Kyung-Mi

“…CD160 and BTLA both bind to herpes virus entry mediator. Although a negative regulatory function of BTLA in natural killer T (NKT) cell activation has been…”
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Immunologic and Tissue Biocompatibility of Flexible/Stretchable Electronics and Optoelectronics by Park, Gayoung, Chung, Hyun-Joong, Kim, Kwanghee, Lim, Seon Ah, Kim, Jiyoung, Kim, Yun-Soung, Liu, Yuhao, Yeo, Woon-Hong, Kim, Rak-Hwan, Kim, Stanley S., Kim, Jong-Seon, Jung, Yei Hwan, Kim, Tae-il, Yee, Cassian, Rogers, John A., Lee, Kyung-Mi

“…Recent development of flexible/stretchable integrated electronic sensors and stimulation systems has the potential to establish an important paradigm for…”
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Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice by Shin, Suk Chul, Lee, Kyung-Mi, Kang, Yu Mi, Kim, Kwanghee, Lim, Seon Ah, Yang, Kwang Hee, Kim, Ji Young, Nam, Seon Young, Kim, Hee Sun

“…AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these…”
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Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy by SEON AH LIM, KIM, Tae-Jin, YEE, Cassian, KUMAR, Vinay, LEE, Kyung-Mi, JUNG EUN LEE, CHUNG HEE SONN, KIM, Kwanghee, KIM, Jiyoung, JONG GWON CHOI, CHOI, Ii-Kyu, YUN, Chae-Ok, KIM, Jae-Hong

“…Adoptive natural killer (NK) cell therapy may offer an effective treatment regimen for cancer patients whose disease is refractory to conventional therapy. NK…”
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Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy by Lim, Seon Ah

“…Immunotherapy represents a promising treatment strategy for targeting various tumor types. However, the overall response rate is low due to the tumor…”
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Lipid metabolism in T cell signaling and function by Lim, Seon Ah, Su, Wei, Chapman, Nicole M., Chi, Hongbo

“…T cells orchestrate adaptive immunity against pathogens and other immune challenges, but their dysfunction can also mediate the pathogenesis of cancer and…”
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Lipid signalling enforces functional specialization of T reg cells in tumours by Lim, Seon Ah, Wei, Jun, Nguyen, Thanh-Long M, Shi, Hao, Su, Wei, Palacios, Gustavo, Dhungana, Yogesh, Chapman, Nicole M, Long, Lingyun, Saravia, Jordy, Vogel, Peter, Chi, Hongbo

“…Regulatory T cells (T cells) are essential for immune tolerance , but also drive immunosuppression in the tumour microenvironment . Therapeutic targeting of T…”
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Lipid signalling enforces functional specialization of Treg cells in tumours by Lim, Seon Ah, Wei, Jun, Nguyen, Thanh-Long M., Shi, Hao, Su, Wei, Palacios, Gustavo, Dhungana, Yogesh, Chapman, Nicole M., Long, Lingyun, Saravia, Jordy, Vogel, Peter, Chi, Hongbo

“…Regulatory T cells (T reg cells) are essential for immune tolerance 1 , but also drive immunosuppression in the tumour microenvironment 2 . Therapeutic…”
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Single Step Isolation and Activation of Primary CD3+ T Lymphocytes Using Alcohol-Dispersed Electrospun Magnetic Nanofibers by Kim, Kwanghee, An, Hyo Jin, Jun, Seung-Hyun, Kim, Tae-Jin, Lim, Seon Ah, Park, Gayoung, Na, Hyon Bin, Park, Yong Il, Hyeon, Taeghwan, Yee, Cassian, Bluestone, Jeffrey A, Kim, Jungbae, Lee, Kyung-Mi

“…Electrospun polymer nanofibers with entrapped magnetic nanoparticles (magnetic NP–NF) represent a novel scaffold substrate that can be functionalized for…”
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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity by Guo, Chuansheng, You, Zhiyuan, Shi, Hao, Sun, Yu, Du, Xingrong, Palacios, Gustavo, Guy, Cliff, Yuan, Sujing, Chapman, Nicole M., Lim, Seon Ah, Sun, Xiang, Saravia, Jordy, Rankin, Sherri, Dhungana, Yogesh, Chi, Hongbo

“…Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1 , 2 . Dendritic cells (DCs),…”
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Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity by Karmaus, Peer W. F., Chen, Xiang, Lim, Seon Ah, Herrada, Andrés A., Nguyen, Thanh-Long M., Xu, Beisi, Dhungana, Yogesh, Rankin, Sherri, Chen, Wenan, Rosencrance, Celeste, Yang, Kai, Fan, Yiping, Cheng, Yong, Easton, John, Neale, Geoffrey, Vogel, Peter, Chi, Hongbo

“…A defining feature of adaptive immunity is the development of long-lived memory T cells to curtail infection. Recent studies have identified a unique stem-like…”
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Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer by Zhou, Peipei, Shi, Hao, Huang, Hongling, Sun, Xiang, Yuan, Sujing, Chapman, Nicole M., Connelly, Jon P., Lim, Seon Ah, Saravia, Jordy, KC, Anil, Pruett-Miller, Shondra M., Chi, Hongbo

“…CD8 + cytotoxic T cells (CTLs) orchestrate antitumour immunity and exhibit inherent heterogeneity 1 , 2 , with precursor exhausted T (T pex ) cells but not…”
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