Search Results - "Lim, See Wee"

A STAT3-based gene signature stratifies glioma patients for targeted therapy by Tan, Melanie Si Yan, Sandanaraj, Edwin, Chong, Yuk Kien, Lim, See Wee, Koh, Lynnette Wei Hsien, Ng, Wai Hoe, Tan, Nguan Soon, Tan, Patrick, Ang, Beng Ti, Tang, Carol

“…Intratumoral heterogeneity is a hallmark of glioblastoma (GBM) tumors, thought to negatively influence therapeutic outcome. Previous studies showed that…”
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Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors by Zhang, Yan, Wong, Chi Yan, Lim, Carine Z. J., Chen, Qingchang, Yu, Zhonglang, Natalia, Auginia, Wang, Zhigang, Pang, Qing You, Lim, See Wee, Loh, Tze Ping, Ang, Beng Ti, Tang, Carol, Shao, Huilin

“…Current technologies to subtype glioblastoma (GBM), the most lethal brain tumor, require highly invasive brain biopsies. Here, we develop a dedicated…”
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Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma by Xu, Liang, Chen, Ye, Mayakonda, Anand, Koh, Lynnette, Chong, Yuk Kien, Buckley, Dennis L., Sandanaraj, Edwin, Lim, See Wee, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Huang, Mo-Li, Chen, Jianxiang, Sun, Wendi, Wang, Ling-Zhi, Goh, Boon Cher, Dinh, Huy Q., Kappei, Dennis, Winter, Georg E., Ding, Ling-Wen, Ang, Beng Ti, Berman, Benjamin P., Bradner, James E., Tang, Carol, Koeffler, H. Phillip

“…Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers…”
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Integrative multi-omics approach to targeted therapy for glioblastoma by Koh, Lynnette, Novera, Wisna, Lim, See Wee, Chong, Yuk Kien, Pang, Qing You, Low, David, Ang, Beng Ti, Tang, Carol

“…This review describes recent technological advances applied to glioblastoma (GBM), a brain tumor with dismal prognosis. International consortial efforts…”
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Epi-Detected Hyperspectral Stimulated Raman Scattering Microscopy for Label-Free Molecular Subtyping of Glioblastomas by Bae, Kideog, Zheng, Wei, Lin, Kan, Lim, See Wee, Chong, Yuk Kien, Tang, Carol, King, Nicolas K, Ti Ang, Christopher Beng, Huang, Zhiwei

“…We report the development and implementation of an epi-detected spectral-focusing hyperspectral stimulated Raman scattering (SRS) imaging technique for…”
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EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma by Koh, Lynnette Wei Hsien, Pang, Qing You, Novera, Wisna, Lim, See Wee, Chong, Yuk Kien, Liu, Jinyue, Ang, Samantha Ya Lyn, Loh, Ron Weng Yee, Shao, Huilin, Ching, Jianhong, Wang, Yulan, Yip, Stephen, Tan, Patrick, Li, Shang, Low, David Chyi Yeu, Phelan, Anne, Rosser, Gabriel, Tan, Nguan Soon, Tang, Carol, Ang, Beng Ti

“…EZH2, well-known for its canonical methyltransferase activity in transcriptional repression in many cancers including glioblastoma (GBM), has an understudied…”
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DEAD-box helicase DP103 defines metastatic potential of human breast cancers by Shin, Eun Myoung, Hay, Hui Sin, Lee, Moon Hee, Goh, Jen Nee, Tan, Tuan Zea, Sen, Yin Ping, Lim, See Wee, Yousef, Einas M, Ong, Hooi Tin, Thike, Aye Aye, Kong, Xiangjun, Wu, Zhengsheng, Mendoz, Earnest, Sun, Wei, Salto-Tellez, Manuel, Lim, Chwee Teck, Lobie, Peter E, Lim, Yoon Pin, Yap, Celestial T, Zeng, Qi, Sethi, Gautam, Lee, Martin B, Tan, Patrick, Goh, Boon Cher, Miller, Lance D, Thiery, Jean Paul, Zhu, Tao, Gaboury, Louis, Tan, Puay Hoon, Hui, Kam Man, Yip, George Wai-Cheong, Miyamoto, Shigeki, Kumar, Alan Prem, Tergaonkar, Vinay

“…Despite advancement in breast cancer treatment, 30% of patients with early breast cancers experience relapse with distant metastasis. It is a challenge to…”
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Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities by Xu, Liang, Chen, Ye, Huang, Yulun, Sandanaraj, Edwin, Yu, John S., Lin, Ruby Yu-Tong, Dakle, Pushkar, Ke, Xin-Yu, Chong, Yuk Kien, Koh, Lynnette, Mayakonda, Anand, Nacro, Kassoum, Hill, Jeffrey, Huang, Mo-Li, Gery, Sigal, Lim, See Wee, Huang, Zhengyun, Xu, Ying, Chen, Jianxiang, Bai, Longchuan, Wang, Shaomeng, Wakimoto, Hiroaki, Yeo, Tseng Tsai, Ang, Beng Ti, Müschen, Markus, Tang, Carol, Tan, Tuan Zea, Koeffler, Phillip H.

“…Abstract Background: Glioblastoma (GBM) is the most aggressive and therapy-refractory brain tumor in adults. Molecular profiling of GBM on the basis of gene…”
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CSIG-03. STAT3-BASED PATIENT STRATIFICATION IN PRECISION NEURO-ONCOLOGY by Tan, Melanie, Sandanaraj, Edwin, Chong, Yuk-Kien, Lim, See-Wee, Koh, Lynnette, Ng, Wai-Hoe, Tan, Nguan-Soon, Tan, Patrick, Ang, Beng-Ti, Tang, Carol

“…Abstract Glioblastoma (GBM) displays both spatial and temporal heterogeneity, whereupon mesenchymal tumors fare more poorly than the proneural molecular…”
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Topography of transcriptionally active chromatin in glioblastoma by Xu, Liang, Chen, Ye, Huang, Yulun, Sandanaraj, Edwin, Yu, John S, Lin, Ruby Yu-Tong, Dakle, Pushkar, Ke, Xin-Yu, Chong, Yuk Kien, Koh, Lynnette, Mayakonda, Anand, Nacro, Kassoum, Hill, Jeffrey, Huang, Mo-Li, Gery, Sigal, Lim, See Wee, Huang, Zhengyun, Xu, Ying, Chen, Jianxiang, Bai, Longchuan, Wang, Shaomeng, Wakimoto, Hiroaki, Yeo, Tseng Tsai, Ang, Beng Ti, Müschen, Markus, Tang, Carol, Tan, Tuan Zea, Koeffler, H Phillip

“…Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylation, and genomic variations advances…”
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