Search Results - "Lim, Pilar"

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study by Canuso, Carla M, Singh, Jaskaran B, Fedgchin, Maggie, Alphs, Larry, Lane, Rosanne, Lim, Pilar, Pinter, Christine, Hough, David, Sanacora, Gerard, Manji, Husseini, Drevets, Wayne C

“…Objective:The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major…”
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Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): Results of a 6-week, randomized, placebo-controlled study by Davidson, Michael, Emsley, Robin, Kramer, Michelle, Ford, Lisa, Pan, Guohua, Lim, Pilar, Eerdekens, Mariëlle

“…Abstract Background Paliperidone extended-release tablet (paliperidone ER) is an oral psychotropic agent developed for schizophrenia treatment. Paliperidone…”
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Efficacy and Safety of Paliperidone Extended-Release Tablets: Results of a 6-Week, Randomized, Placebo-Controlled Study by Marder, Stephen R, Kramer, Michelle, Ford, Lisa, Eerdekens, Els, Lim, Pilar, Eerdekens, Mariëlle, Lowy, Adam

“…Background Paliperidone extended-release tablet (paliperidone ER; Invega, Janssen L.P., Titusville, New Jersey) is an oral psychotropic for schizophrenia…”
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A Controlled, Evidence-Based Trial of Paliperidone Palmitate, A Long-Acting Injectable Antipsychotic, in Schizophrenia by NASRALLAH, Henry A, GOPAL, Srihari, GASSMANN-MAYER, Cristiana, QUIROZ, Jorge A, LIM, Pilar, EERDEKENS, Mariëlle, YUEN, Eric, HOUGH, David

“…Paliperidone palmitate is a long-acting injectable antipsychotic agent. This 13-week, multicenter, randomized (1 : 1 : 1 : 1), double-blind, parallel-group…”
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Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia by Hough, David, Lindenmayer, Jean-Pierre, Gopal, Srihari, Melkote, Rama, Lim, Pilar, Herben, Virginie, Yuen, Eric, Eerdekens, Marielle

“…Paliperidone palmitate is an investigational, injectable atypical antipsychotic. The safety and tolerability of initiating treatment with paliperidone…”
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Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: A randomized, placebo-controlled study by Berwaerts, Joris, Lane, Rosanne, Nuamah, Isaac F, Lim, Pilar, Remmerie, Bart, Hough, David W

“…Abstract Background Combination treatment with atypical antipsychotics and a mood stabilizer is often recommended for treatment of manic or mixed episodes…”
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A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder by Vieta, Eduard, Nuamah, Isaac F, Lim, Pilar, Yuen, Eric C, Palumbo, Joseph M, Hough, David W, Berwaerts, Joris

“…Vieta E, Nuamah IF, Lim P, Yuen EC, Palumbo JM, Hough DW, Berwaerts J. A randomized, placebo‐ and active‐controlled study of paliperidone extended release for…”
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Efficacy and safety of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 52-week open-label studies by Emsley, Robin, Berwaerts, Joris, Eerdekens, Mariëlle, Kramer, Michelle, Lane, Rosanne, Lim, Pilar, Hough, David, Palumbo, Joseph

“…Long-term efficacy and safety of paliperidone extended-release tablets (3−12 mg/day) were evaluated in pooled data from 52-week open-label extension (OLE)…”
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Safety and Tolerability of Oral Paliperidone Extended-Release Tablets in Elderly Patients With Schizophrenia: A Double-Blind, Placebo-Controlled Study With Six-Month Open-Label Extension by Tzimos, Andreas, M.D, Samokhvalov, Viktor, M.D., Ph.D, Kramer, Michelle, M.D., M.P.H, Ford, Lisa, M.D, Gassmann-Mayer, Cristiana, Ph.D, Lim, Pilar, Ph.D, Eerdekens, Mariëlle, M.D., M.B.A

“…Objective The objective of this multicenter, international study was to evaluate safety and tolerability of paliperidone extended-release (ER) tablets in…”
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On clinical trials with a high placebo response rate by Chi, George Y.H, Li, Yihan, Liu, Yanning, Lewin, David, Lim, Pilar

“…Abstract The basic problem that causes the frequent failure of a standard randomized parallel placebo-controlled clinical trial with a high placebo response…”
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Topiramate Monotherapy for Partial Onset Seizures by Sachdeo, Rajesh C., Reife, Ross A., Lim, Pilar, Pledger, Gordon

“…Purpose: Evaluation of topiramate (TPM) as monotherapy in patients with uncontrolled partial onset seizures. Methods: A total of 48 patients were evaluated in…”
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Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study by Popova, Vanina, Daly, Ella J, Trivedi, Madhukar, Cooper, Kimberly, Lane, Rosanne, Lim, Pilar, Mazzucco, Christine, Hough, David, Thase, Michael E, Shelton, Richard C, Molero, Patricio, Vieta, Eduard, Bajbouj, Malek, Manji, Husseini, Drevets, Wayne C, Singh, Jaskaran B

“…About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants. This study compared the efficacy and…”
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Effects on serum lipid profiles of continuous 17β-estradiol, intermittent norgestimate regimens versus continuous combined 17β-estradiol/ norethisterone acetate hormone replacement therapy by Ylikorkala, Olavi, Lim, Pilar, Caubel, Patrick

“…Abstract To compare the effects of a daily oral 1-mg dose of continuous 17β-estradiol (E 2) plus intermittent (3 days off, 3 days on) norgestimate (NGM) 90 μg…”
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Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent: Double-Blind, Randomized Study (ASPIRE I) by Fu, Dong-Jing, Ionescu, Dawn F, Li, Xiang, Lane, Rosanne, Lim, Pilar, Sanacora, Gerard, Hough, David, Manji, Husseini, Drevets, Wayne C, Canuso, Carla M

“…To compare esketamine to placebo, each in addition to standard-of-care treatment, for rapidly reducing major depressive disorder symptoms, including suicidal…”
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Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial by Daly, Ella J, Singh, Jaskaran B, Fedgchin, Maggie, Cooper, Kimberly, Lim, Pilar, Shelton, Richard C, Thase, Michael E, Winokur, Andrew, Van Nueten, Luc, Manji, Husseini, Drevets, Wayne C

“…Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants. To assess the efficacy, safety, and…”
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Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial by Daly, Ella J, Trivedi, Madhukar H, Janik, Adam, Li, Honglan, Zhang, Yun, Li, Xiang, Lane, Rosanne, Lim, Pilar, Duca, Anna R, Hough, David, Thase, Michael E, Zajecka, John, Winokur, Andrew, Divacka, Ilona, Fagiolini, Andrea, Cubala, Wieslaw J, Bitter, István, Blier, Pierre, Shelton, Richard C, Molero, Patricio, Manji, Husseini, Drevets, Wayne C, Singh, Jaskaran B

“…Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. To…”
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Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II) by Ionescu, Dawn F, Fu, Dong-Jing, Qiu, Xin, Lane, Rosanne, Lim, Pilar, Kasper, Siegfried, Hough, David, Drevets, Wayne C, Manji, Husseini, Canuso, Carla M

“…Abstract Background Patients with major depressive disorder (MDD) having active suicidal ideation with intent require immediate treatment. Methods This…”
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Guidelines for the Content of Statistical Analysis Plans in Clinical Trials by Gamble, Carrol, Krishan, Ashma, Stocken, Deborah, Lewis, Steff, Juszczak, Edmund, Doré, Caroline, Williamson, Paula R, Altman, Douglas G, Montgomery, Alan, Lim, Pilar, Berlin, Jesse, Senn, Stephen, Day, Simon, Barbachano, Yolanda, Loder, Elizabeth

“…IMPORTANCE: While guidance on statistical principles for clinical trials exists, there is an absence of guidance covering the required content of statistical…”
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Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1) by Fedgchin, Maggie, Trivedi, Madhukar, Daly, Ella J, Melkote, Rama, Lane, Rosanne, Lim, Pilar, Vitagliano, Dawn, Blier, Pierre, Fava, Maurizio, Liebowitz, Michael, Ravindran, Arun, Gaillard, Raphael, Ameele, Hans Van Den, Preskorn, Sheldon, Manji, Husseini, Hough, David, Drevets, Wayne C, Singh, Jaskaran B

“…About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have…”
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A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression by Singh, Jaskaran B., Fedgchin, Maggie, Daly, Ella J., De Boer, Peter, Cooper, Kimberly, Lim, Pilar, Pinter, Christine, Murrough, James W., Sanacora, Gerard, Shelton, Richard C., Kurian, Benji, Winokur, Andrew, Fava, Maurizio, Manji, Husseini, Drevets, Wayne C., Van Nueten, Luc

“…Objective:Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with…”
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