Search Results - "Lim, Michelle Gek Liang"

DUBStepR is a scalable correlation-based feature selection method for accurately clustering single-cell data by Ranjan, Bobby, Sun, Wenjie, Park, Jinyu, Mishra, Kunal, Schmidt, Florian, Xie, Ronald, Alipour, Fatemeh, Singhal, Vipul, Joanito, Ignasius, Honardoost, Mohammad Amin, Yong, Jacy Mei Yun, Koh, Ee Tzun, Leong, Khai Pang, Rayan, Nirmala Arul, Lim, Michelle Gek Liang, Prabhakar, Shyam

“…Feature selection (marker gene selection) is widely believed to improve clustering accuracy, and is thus a key component of single cell clustering pipelines…”
Get full text

Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes by Honardoost, Mohammad Amin, Adinatha, Andreas, Schmidt, Florian, Ranjan, Bobby, Ghaeidamini, Maryam, Arul Rayan, Nirmala, Gek Liang Lim, Michelle, Joanito, Ignasius, Xiao Xuan Lin, Quy, Rajagopalan, Deepa, Qi Mok, Shi, Hwang, You Yi, Larbi, Anis, Khor, Chiea Chuen, Foo, Roger, Boehm, Bernhard Otto, Prabhakar, Shyam

“…Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting…”
Get full text

Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression by Hu, Lingling, Chen, Xin, Narwade, Nitin, Lim, Michelle Gek Liang, Chen, Zikai, Tennakoon, Chandana, Guan, Peiyong, Chan, Un In, Zhao, Zuxianglan, Deng, Mokan, Xu, Xiaoling, Sung, Wing-Kin, Cheung, Edwin

“…Androgen receptor (AR) plays a central role in driving prostate cancer (PCa) progression. How AR promotes this process is still not completely clear. Herein,…”
Get full text

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer by Zhu, Detu, Zhao, Zuxianglan, Cui, Guimei, Chang, Shiehong, Hu, Lingling, See, Yi Xiang, Lim, Michelle Gek Liang, Guo, Dajiang, Chen, Xin, Poudel, Barun, Robson, Paul, Luo, Yumei, Cheung, Edwin

“…Estrogen drives breast cancer (BCa) progression by directly activating estrogen receptor α (ERα). However, because of the stochastic nature of gene…”
Get full text

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer by Zhu, Detu, Zhao, Zuxianglan, Cui, Guimei, Chang, Shiehong, Hu, Lingling, See, Yi Xiang, Liang Lim, Michelle Gek, Guo, Dajiang, Chen, Xin, Poudel, Barun, Robson, Paul, Luo, Yumei, Cheung, Edwin

Get full text

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia by Krishnan, Vaidehi, Schmidt, Florian, Nawaz, Zahid, Venkatesh, Prasanna Nori, Lee, Kian Leong, Ren, Xi, Chan, Zhu En, Yu, Mengge, Makheja, Meera, Rayan, Nirmala Arul, Lim, Michelle Gek Liang, Cheung, Alice Man Sze, Bari, Sudipto, Chng, Wee Joo, Than, Hein, Ouyang, John, Rackham, Owen, Tan, Tuan Zea, Hwang, William Ying Khee, Chuah, Charles, Prabhakar, Shyam, Ong, S. Tiong

“…•A high-resolution single-cell map of diagnostic CML bone marrow to annotate features of TKI resistance.•Gene expression signatures within the LSCs and NK…”
Get full text

Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain by Rayan, Nirmala Arul, Aow, Jonathan, Lim, Michelle Gek Liang, Arcego, Danusa Mar, Ryan, Richard, Nourbakhsh, Nooshin, de Lima, Randriely Merscher Sobreira, Craig, Kelly, Zhang, Tie Yuan, Goh, Yeek Teck, Sun, Alfred Xuyang, Tompkins, Thomas, Bronner, Stéphane, Binda, Sylvie, Diorio, Josie, Parent, Carine, Meaney, Michael J., Prabhakar, Shyam

“…Understanding the shared and divergent mechanisms across antidepressant (AD) classes and probiotics is critical for improving treatment for mood disorders…”
Get full text

Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling by Rayan, Nirmala Arul, Kumar, Vibhor, Aow, Jonathan, Rastegar, Naghmeh, Lim, Michelle Gek Liang, O’Toole, Nicholas, Aliwarga, Edita, Arcego, Danusa Mar, Yeo, Hui Ting Grace, Wong, Jen Yi, Lee, May Yin, Schmidt, Florian, Haja, Hajira Shreen, Tam, Wai Leong, Zhang, Tie-Yuan, Diorio, Josie, Anacker, Christoph, Hen, Rene, Parent, Carine, Meaney, Michael J, Prabhakar, Shyam

“…Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they…”
Get full text

A Single-Cell Atlas Identifies Pretreatment Features of Primary Imatinib Resistance in Chronic Myeloid Leukemia by Krishnan, Vaidehi, Schmidt, Florian, Nawaz, Zahid, Lee, Kian Leong, Nori Venkatesh, Prasanna, Makheja, Meera, Chan, Zhu En, Yu, Mengge, Arul Rayan, Nirmala, Gek Liang Lim, Michelle, Cheung, Alice, Bari, Sudipto, Ouyang, John, Rackham, Owen, Tan, Tuan Zea, Hwang, William YK, Chuah, Charles, Prabhakar, Shyam, Ong, Sin Tiong

Get full text

Studying Protein–DNA Complexes Using Gold Nanoparticles by Exploiting Particle Aggregation, Refractive Index Change, and Fluorescence Quenching and Enhancement Principles by Sutarlie, Laura, Aung, Khin Moh Moh, Lim, Michelle Gek Liang, Lukman, Steven, Cheung, Edwin, Su, Xiaodi

“…Gold nanoparticles (AuNPs) have a unique optical phenomena termed localized surface plasmon resonance that is determined by particle shape, size, interparticle…”
Get full text

Studying forkhead box protein A1–DNA interaction and ligand inhibition using gold nanoparticles, electrophoretic mobility shift assay, and fluorescence anisotropy by Aung, Khin Moh Moh, New, Siu Yee, Hong, Shuzhen, Sutarlie, Laura, Lim, Michelle Gek Liang, Tan, Si Kee, Cheung, Edwin, Su, Xiaodi

“…Forkhead box protein 1 (FoxA1) is a member of the forkhead family of winged helix transcription factors that plays pivotal roles in the development and…”
Get full text