Search Results - "Lim, Kuan Hon"

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway by Soo, Hsien-Chuen, Chung, Felicia Fei-Lei, Lim, Kuan-Hon, Yap, Veronica Alicia, Bradshaw, Tracey D, Hii, Ling-Wei, Tan, Si-Hoey, See, Sze-Jia, Tan, Yuen-Fen, Leong, Chee-Onn, Mai, Chun-Wai

“…Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative activities. However, the mechanisms by which Cud C induced…”
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Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects by Mak, Yin‐Ying, Loong, Bi‐Juin, Millns, Paul, Bauer, Claudia C., Bon, Robin S., Mbaki, Yvonne, Lee, Fong‐Kai, Lim, Kuan‐Hon, Kong, Cin, Then, Sue‐Mian, Ting, Kang‐Nee

“…This study investigated the vasorelaxant effects of schwarzinicine A, an alkaloid recently reported from Ficus schwarzii Koord. Regulation of calcium…”
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In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B by Qazzaz, Mohannad E, Raja, Vijay J, Lim, Kuan-Hon, Kam, Toh-Seok, Lee, Jong Bong, Gershkovich, Pavel, Bradshaw, Tracey D

“…Highlights • Natural product indole alkaloid. • Anticancer activity. • Elucidation of mechanisms of action: Microtubule disrupting agent; inhibitor of PLK1;…”
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Macroline, talpinine, and sarpagine alkaloids from Alstonia penangiana. An NMR-based method for differentiating between A. penangiana and A. macrophylla by Yeap, Joanne Soon-Yee, Tan, Chun-Hoe, Yong, Kien-Thai, Lim, Kuan-Hon, Lim, Siew-Huah, Low, Yun-Yee, Kam, Toh-Seok

“…Fourteen previously undescribed alkaloids comprising two N-1-hydroxymethylmacroline alkaloids, one talpinine-type oxindole acetal, a pair of equilibrating…”
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A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra by Chu, Jin-Ning, Krishnan, Premanand, Lim, Kuan-Hon

“…Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to…”
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The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun by Alhuthali, Hayaa Moeed, Bradshaw, Tracey D, Lim, Kuan-Hon, Kam, Toh-Seok, Seedhouse, Claire H

“…Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are…”
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Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B by Lee, Fong-Kai, Krishnan, Premanand, Muhamad, Azira, Low, Yun-Yee, Kam, Toh-Seok, Ting, Kang-Nee, Lim, Kuan-Hon

“…A concise synthesis of the 1,4-diarylbutanoid-phenethylamine alkaloids, schwarzinicines A (1) and B (2), recently isolated from Ficus schwarzii, is reported…”
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Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules by Raja, Vijay J., Lim, Kuan-Hon, Leong, Chee-Onn, Kam, Toh-Seok, Bradshaw, Tracey D.

“…Summary Natural products play a pivotal role in the treatment of cancer; identification of compounds such as taxanes and the vinca alkaloids were seminal…”
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Jerantinines A−G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa by Lim, Kuan-Hon, Hiraku, Osamu, Komiyama, Kanki, Kam, Toh-Seok

“…Seven new indole alkaloids of the Aspidosperma type, jerantinines A−G (1−7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The…”
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Biologically Active Indole Alkaloids from Kopsia arborea by Lim, Kuan-Hon, Hiraku, Osamu, Komiyama, Kanki, Koyano, Takashi, Hayashi, Masahiko, Kam, Toh-Seok

“…Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A…”
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Transformations of the 2,7-Seco Aspidosperma Alkaloid Leuconolam, Structure Revision of epi-Leuconolam, and Partial Syntheses of Leuconoxine and Leuconodines A and F by Low, Yun-Yee, Hong, Fong-Jiao, Lim, Kuan-Hon, Thomas, Noel F, Kam, Toh-Seok

“…Several transformations of the seco Aspidosperma alkaloid leuconolam were carried out. The based-induced reaction resulted in cyclization to yield two epimers,…”
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Criofolinine and Vernavosine, New Pentacyclic Indole Alkaloids Incorporating Pyrroloazepine and Pyridopyrimidine Moieties Derived from a Common Yohimbine Precursor by Nge, Choy-Eng, Gan, Chew-Yan, Lim, Kuan-Hon, Ting, Kang-Nee, Low, Yun-Yee, Kam, Toh-Seok

“…Two new indole alkaloids characterized by previously unencountered natural product skeletons, viz., criofolinine (1), incorporating a pyrroloazepine motif…”
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Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site by Smedley, Christopher J., Stanley, Paul A., Qazzaz, Mohannad E., Prota, Andrea E., Olieric, Natacha, Collins, Hilary, Eastman, Harry, Barrow, Andrew S., Lim, Kuan-Hon, Kam, Toh-Seok, Smith, Brian J., Duivenvoorden, Hendrika M., Parker, Belinda S., Bradshaw, Tracey D., Steinmetz, Michel O., Moses, John E.

“…The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer…”
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Inhibitory effect of Duabanga grandiflora on MRSA biofilm formation via prevention of cell-surface attachment and PBP2a production by Santiago, Carolina, Lim, Kuan-Hon, Loh, Hwei-San, Ting, Kang Nee

“…Formation of biofilms is a major factor for nosocomial infections associated with methicillin-resistance Staphylococcus aureus (MRSA). This study was carried…”
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Arboflorine, an Unusual Pentacyclic Monoterpenoid Indole Alkaloid Incorporating a Third Nitrogen Atom by Lim, Kuan-Hon, Kam, Toh-Seok

“…A new indole alkaloid, arboflorine, possessing a novel pentacyclic carbon skeleton and incorporating a third nitrogen atom was obtained from the Malayan Kopsia…”
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Conoliferine and isoconoliferine, structurally novel alkaloid-lignan conjugates from Tabernaemontana corymbosa by Lim, Kuan-Hon, Kam, Toh-Seok

“…Conoliferine and isoconoliferine were isolated from Tabernaemontana corymbosa as an unresolvable mixture of (1′ S, 2′ S)- and (1′ R, 2′ R)-diastereomers. These…”
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Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia by Lim, Kuan-Hon, Low, Yun-Yee, Kam, Toh-Seok

“…A new pentacyclic indole alkaloid of the pericine-type, valparicine, representing the first member of this sub-group, was obtained from a Malayan Kopsia…”
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Reversal of Ampicillin Resistance in MRSA via Inhibition of Penicillin-Binding Protein 2a by Acalypha wilkesiana by Santiago, Carolina, Pang, Ee Leen, Lim, Kuan-Hon, Loh, Hwei-San, Ting, Kang Nee

“…The inhibitory activity of a semipure fraction from the plant, Acalypha wilkesiana assigned as 9EA-FC-B, alone and in combination with ampicillin, was studied…”
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Mersicarpine, an unusual tetracyclic dihydroindole alkaloid incorporating a seven-membered imine ring by Kam, Toh-Seok, Subramaniam, G, Lim, Kuan-Hon, Choo, Yeun-Mun

“…A novel dihydroindole derivative, mersicarpine, incorporating a novel tetracyclic carbon skeleton, containing a seven-membered imine ring, was obtained from a…”
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Secoleuconoxine and Oxopericine Derivatives from Kopsia by Lim, Kuan-Hon, Kam, Toh-Seok

“…Two new indole alkaloids, viz., arboloscine (1), the first example of a secoleuconoxine, and pericidine (5), an oxidized derivative of pericine (6), were…”
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