Search Results - "Lim, Klothilda"

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing by Pan, Deng, Kobayashi, Aya, Jiang, Peng, Ferrari de Andrade, Lucas, Tay, Rong En, Luoma, Adrienne M, Tsoucas, Daphne, Qiu, Xintao, Lim, Klothilda, Rao, Prakash, Long, Henry W, Yuan, Guo-Cheng, Doench, John, Brown, Myles, Liu, X Shirley, Wucherpfennig, Kai W

“…Many human cancers are resistant to immunotherapy, for reasons that are poorly understood. We used a genome-scale CRISPR-Cas9 screen to identify mechanisms of…”
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Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer by Baca, Sylvan C., Takeda, David Y., Seo, Ji-Heui, Hwang, Justin, Ku, Sheng Yu, Arafeh, Rand, Arnoff, Taylor, Agarwal, Supreet, Bell, Connor, O’Connor, Edward, Qiu, Xintao, Alaiwi, Sarah Abou, Corona, Rosario I., Fonseca, Marcos A. S., Giambartolomei, Claudia, Cejas, Paloma, Lim, Klothilda, He, Monica, Sheahan, Anjali, Nassar, Amin, Berchuck, Jacob E., Brown, Lisha, Nguyen, Holly M., Coleman, Ilsa M., Kaipainen, Arja, De Sarkar, Navonil, Nelson, Peter S., Morrissey, Colm, Korthauer, Keegan, Pomerantz, Mark M., Ellis, Leigh, Pasaniuc, Bogdan, Lawrenson, Kate, Kelly, Kathleen, Zoubeidi, Amina, Hahn, William C., Beltran, Himisha, Long, Henry W., Brown, Myles, Corey, Eva, Freedman, Matthew L.

“…Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism of adaptive resistance to targeted therapy in cancer. An…”
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Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer by Cejas, Paloma, Xie, Yingtian, Font-Tello, Alba, Lim, Klothilda, Syamala, Sudeepa, Qiu, Xintao, Tewari, Alok K., Shah, Neel, Nguyen, Holly M., Patel, Radhika A., Brown, Lisha, Coleman, Ilsa, Hackeng, Wenzel M., Brosens, Lodewijk, Dreijerink, Koen M. A., Ellis, Leigh, Alaiwi, Sarah Abou, Seo, Ji-Heui, Baca, Sylvan, Beltran, Himisha, Khani, Francesca, Pomerantz, Mark, Dall’Agnese, Alessandra, Crowdis, Jett, Van Allen, Eliezer M., Bellmunt, Joaquim, Morrisey, Colm, Nelson, Peter S., DeCaprio, James, Farago, Anna, Dyson, Nicholas, Drapkin, Benjamin, Liu, X. Shirley, Freedman, Matthew, Haffner, Michael C., Corey, Eva, Brown, Myles, Long, Henry W.

“…Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong…”
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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target by Wang, Xiaoqing, Tokheim, Collin, Gu, Shengqing Stan, Wang, Binbin, Tang, Qin, Li, Yihao, Traugh, Nicole, Zeng, Zexian, Zhang, Yi, Li, Ziyi, Zhang, Boning, Fu, Jingxin, Xiao, Tengfei, Li, Wei, Meyer, Clifford A., Chu, Jun, Jiang, Peng, Cejas, Paloma, Lim, Klothilda, Long, Henry, Brown, Myles, Liu, X. Shirley

“…Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer treatment, ICB benefits for triple-negative breast cancer (TNBC) remain…”
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway by Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

“…Eradicating tumor dormancy that develops following epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small…”
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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence by Wu, Zhong, Zhou, Jin, Zhang, Xiaoyang, Zhang, Zhouwei, Xie, Yingtian, Liu, Jie bin, Ho, Zandra V., Panda, Arpit, Qiu, Xintao, Cejas, Paloma, Cañadas, Israel, Akarca, Fahire Goknur, McFarland, James M., Nagaraja, Ankur K., Goss, Louisa B., Kesten, Nikolas, Si, Longlong, Lim, Klothilda, Liu, Yanli, Zhang, Yanxi, Baek, Ji Yeon, Liu, Yang, Patil, Deepa T., Katz, Jonathan P., Hai, Josephine, Bao, Chunyang, Stachler, Matthew, Qi, Jun, Ishizuka, Jeffrey J., Nakagawa, Hiroshi, Rustgi, Anil K., Wong, Kwok-Kin, Meyerson, Matthew, Barbie, David A., Brown, Myles, Long, Henry, Bass, Adam J.

“…Esophageal squamous cell carcinomas (ESCCs) harbor recurrent chromosome 3q amplifications that target the transcription factor SOX2. Beyond its role as an…”
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FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance by Li, Yihao, Qiu, Xintao, Wang, Xiaoqing, Liu, Hui, Geck, Renee C., Tewari, Alok K., Xiao, Tengfei, Font-Tello, Alba, Lim, Klothilda, Jones, Kristen L., Morrow, Murry, Vadhi, Raga, Kao, Pei-Lun, Jaber, Aliya, Yerrum, Smitha, Xie, Yingtian, Chow, Kin-Hoe, Cejas, Paloma, Nguyen, Quang-Dé, Long, Henry W., Liu, X. Shirley, Toker, Alex, Brown, Myles

“…How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism…”
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Clonal tracing reveals diverse patterns of response to immune checkpoint blockade by Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple…”
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Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression by Mowery, Cody T., Reyes, Jaime M., Cabal-Hierro, Lucia, Higby, Kelly J., Karlin, Kristen L., Wang, Jarey H., Kimmerling, Robert J., Cejas, Paloma, Lim, Klothilda, Li, Hubo, Furusawa, Takashi, Long, Henry W., Pellman, David, Chapuy, Bjoern, Bustin, Michael, Manalis, Scott R., Westbrook, Thomas F., Lin, Charles Y., Lane, Andrew A.

“…Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with…”
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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity by Watt, April C, Cejas, Paloma, DeCristo, Molly J, Metzger-Filho, Otto, Lam, Enid Y N, Qiu, Xintao, BrinJones, Haley, Kesten, Nikolas, Coulson, Rhiannon, Font-Tello, Alba, Lim, Klothilda, Vadhi, Raga, Daniels, Veerle W, Montero, Joan, Taing, Len, Meyer, Clifford A, Gilan, Omer, Bell, Charles C, Korthauer, Keegan D, Giambartolomei, Claudia, Pasaniuc, Bogdan, Seo, Ji-Heui, Freedman, Matthew L, Ma, Cynthia, Ellis, Matthew J, Krop, Ian, Winer, Eric, Letai, Anthony, Brown, Myles, Dawson, Mark A, Long, Henry W, Zhao, Jean J, Goel, Shom

“…Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that…”
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S188: CAR‐T CELLS SHAPE THE IMMUNOLOGICAL POTENTIAL OF THE TUMOR MICROENVIRONMENT by Frede, Julia, Poller, Julia, Shi, Kayleen, Stuart, Hannah, Sotoudeh, Noori, Lim, Klothilda, Wiggers, Caroline, Waldschmidt, Johannes, Dimitrova, Valeriya, Montanaro, Anna, Cho, Eugene, Vijaykumar, Tushara, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth, Martin, Nathan, Kaiser, Shari, Raab, Marc‐Steffen, Knoechel, Birgit, Lohr, Jens

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700 Increasing MHC-I expression to potentiate immune checkpoint blockade therapy by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon, Rodig, Scott, Long, Henry, Gewurz, Benjamin, Stephen Hodi, F., Brown, Myles, Shirley Liu, X

“…BackgroundCancer immunotherapy, especially immune checkpoint blockade (ICB) therapy, is leading to a paradigm shift in cancer treatment, as a small percentage…”
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer by Shu, Shaokun, Wu, Hua-Jun, Ge, Jennifer Y., Zeid, Rhamy, Harris, Isaac S., Jovanović, Bojana, Murphy, Katherine, Wang, Binbin, Qiu, Xintao, Endress, Jennifer E., Reyes, Jaime, Lim, Klothilda, Font-Tello, Alba, Syamala, Sudeepa, Xiao, Tengfei, Reddy Chilamakuri, Chandra Sekhar, Papachristou, Evangelia K., D’Santos, Clive, Anand, Jayati, Hinohara, Kunihiko, Li, Wei, McDonald, Thomas O., Luoma, Adrienne, Modiste, Rebecca J., Nguyen, Quang-De, Michel, Brittany, Cejas, Paloma, Kadoch, Cigall, Jaffe, Jacob D., Wucherpfennig, Kai W., Qi, Jun, Liu, X. Shirley, Long, Henry, Brown, Myles, Carroll, Jason S., Brugge, Joan S., Bradner, James, Michor, Franziska, Polyak, Kornelia

“…BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired…”
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Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer by Wan, Changxin, Keany, Matthew P, Dong, Han, Al-Alem, Linah F, Pandya, Unnati M, Lazo, Suzan, Boehnke, Karsten, Lynch, Katherine N, Xu, Rui, Zarrella, Dominique T, Gu, Shengqing, Cejas, Paloma, Lim, Klothilda, Long, Henry W, Elias, Kevin M, Horowitz, Neil S, Feltmate, Colleen M, Muto, Michael G, Worley, Jr, Michael J, Berkowitz, Ross S, Matulonis, Ursula A, Nucci, Marisa R, Crum, Christopher P, Rueda, Bo R, Brown, Myles, Liu, Xiaole Shirley, Hill, Sarah J

“…Immune therapies have had limited efficacy in high-grade serous ovarian cancer (HGSC), as the cellular targets and mechanism(s) of action of these agents in…”
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Single-Cell Multi-Omics Reveals Immune Microenvironment Alterations in T-Cell Acute Lymphoblastic Leukemia by Wiggers, Caroline R.M., Cho, Eugene Y., Hegel, Justin, Frede, Julia, Stuart, Hannah, Lim, Klothilda K., Pikman, Yana, Harris, Marian H., Place, Andrew E., Silverman, Lewis B., Lohr, Jens G., Knoechel, Birgit

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ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer by Shah, Neel, Kesten, Nikolas, Font-Tello, Alba, Chang, Matthew E K, Vadhi, Raga, Lim, Klothilda, Flory, Mark R, Cejas, Paloma, Mohammed, Hisham, Long, Henry W, Brown, Myles

“…The TMPRSS2-ERG fusion is the most common genomic rearrangement in human prostate cancer. However, in established adenocarcinoma, it is unknown how the ERG…”
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Combination Therapies to Improve the Efficacy of Immunotherapy in Triple-negative Breast Cancer by Alečković, Maša, Li, Zheqi, Zhou, Ningxuan, Qiu, Xintao, Lulseged, Bethlehem, Foidart, Pierre, Huang, Xiao-Yun, Garza, Kodie, Shu, Shaokun, Kesten, Nikolas, Li, Rong, Lim, Klothilda, Garrido-Castro, Ana C, Guerriero, Jennifer L, Qi, Jun, Long, Henry W, Polyak, Kornelia

“…Immune checkpoint inhibition combined with chemotherapy is currently approved as first-line treatment for patients with advanced PD-L1-positive triple-negative…”
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Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies by Goyette, Marie-Anne, Stevens, Laura E, DePinho, Carolyn R, Seehawer, Marco, Nishida, Jun, Li, Zheqi, Wilde, Callahan M, Li, Rong, Qiu, Xintao, Pyke, Alanna L, Zhao, Stephanie, Lim, Klothilda, Tender, Gabrielle S, Northey, Jason J, Riley, Nicholas M, Long, Henry W, Bertozzi, Carolyn R, Weaver, Valerie M, Polyak, Kornelia

“…Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance. Almost half of the patients with metastatic HER2-positive breast…”
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A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer by Nardone, Agostina, Qiu, Xintao, Spisak, Sandor, Nagy, Zsuzsanna, Feiglin, Ariel, Feit, Avery, Cohen Feit, Gabriela, Xie, Yingtian, Font-Tello, Alba, Guarducci, Cristina, Hermida-Prado, Francisco, Syamala, Sudeepa, Lim, Klothilda, Munoz Gomez, Miguel, Pun, Matthew, Cornwell, MacIntosh, Liu, Weihan, Ors, Aysegul, Mohammed, Hisham, Cejas, Paloma, Brock, Jane B, Freedman, Matthew L, Winer, Eric P, Fu, Xiaoyong, Schiff, Rachel, Long, Henry W, Metzger Filho, Otto, Jeselsohn, Rinath

“…Most invasive lobular breast cancers (ILC) are of the luminal A subtype and are strongly hormone receptor-positive. Yet, ILC is relatively resistant to…”
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