Search Results - "Lim, Kim‐Chew"

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning by Lim, Kim-Chew, Hosoya, Tomonori, Brandt, William, Ku, Chia-Jui, Hosoya-Ohmura, Sakie, Camper, Sally A, Yamamoto, Masayuki, Engel, James Douglas

“…The transcription factor GATA-2 plays vital roles in quite diverse developmental programs, including hematopoietic stem cell (HSC) survival and proliferation…”
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GATA3 is essential for separating patterning domains during facial morphogenesis by Abe, Makoto, Cox, Timothy C, Firulli, Anthony B, Kanai, Stanley M, Dahlka, Jacob, Lim, Kim-Chew, Engel, James Douglas, Clouthier, David E

“…Neural crest cells (NCCs) within the mandibular and maxillary prominences of the first pharyngeal arch are initially competent to respond to signals from…”
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The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice by Cui, Shuaiying, Lim, Kim-Chew, Shi, Lihong, Lee, Mary, Jearawiriyapaisarn, Natee, Myers, Greggory, Campbell, Andrew, Harro, David, Iwase, Shigeki, Trievel, Raymond C., Rivers, Angela, DeSimone, Joseph, Lavelle, Donald, Saunthararajah, Yogen, Engel, James Douglas

“…Inhibition of lysine-specific demethylase 1 (LSD1) has been shown to induce fetal hemoglobin (HbF) levels in cultured human erythroid cells in vitro. Here we…”
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An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation by Yu, Lei, Myers, Greggory, Ku, Chia-Jui, Schneider, Emily, Wang, Yu, Singh, Sharon A., Jearawiriyapaisarn, Natee, White, Andrew, Moriguchi, Takashi, Khoriaty, Rami, Yamamoto, Masayuki, Rosenfeld, Michael G., Pedron, Julien, Bushweller, John H., Lim, Kim-Chew, Engel, James Douglas

“…Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident…”
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GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 by Mahamud, Md Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R Sathish

“…Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the…”
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A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression by Moriguchi, Takashi, Hoshino, Tomofumi, Rao, Arvind, Yu, Lei, Takai, Jun, Uemura, Satoshi, Ise, Kazue, Nakamura, Yasuhiro, Lim, Kim-Chew, Shimizu, Ritsuko, Yamamoto, Masayuki, Engel, James Douglas

“…Transcription factor GATA3 plays vital roles in inner ear development, while regulatory mechanisms controlling its inner ear-specific expression are undefined…”
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Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq by Wang, Bingrui, Wang, Chenchen, Wan, Yang, Gao, Jie, Ma, Yige, Zhang, Yingnan, Tong, Jingyuan, Zhang, Yingchi, Liu, Jinhua, Chang, Lixian, Xu, Changlu, Shen, Biao, Chen, Yumei, Jiang, Erlie, Kurita, Ryo, Nakamura, Yukio, Lim, Kim-Chew, Engel, James Douglas, Zhou, Jiaxi, Cheng, Tao, Zhu, Xiaofan, Zhu, Ping, Shi, Lihong

“…Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell…”
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GATA-3: an unexpected regulator of cell lineage determination in skin by Kaufman, Charles K, Zhou, Ping, Pasolli, H Amalia, Rendl, Michael, Bolotin, Diana, Lim, Kim-Chew, Dai, Xing, Alegre, Maria-Luisa, Fuchs, Elaine

“…Multipotent skin stem cells give rise to epidermis and its appendages, including the hair follicle. The Lef-1/Tcf family of Wnt-regulated transcription factors…”
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PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis by Cui, Shuaiying, Tanabe, Osamu, Lim, Kim-Chew, Xu, H. Eric, Zhou, X. Edward, Lin, Jiandie D., Shi, Lihong, Schmidt, Lindsay, Campbell, Andrew, Shimizu, Ritsuko, Yamamoto, Masayuki, Engel, James Douglas

“…Peroxisome proliferator-activated receptor gamma (PPARγ) coactivator 1α (PGC-1α) and PGC-1β have been shown to be intimately involved in the transcriptional…”
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An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene by Hosoya-Ohmura, Sakie, Lin, Yu-Hsuan, Herrmann, Mary, Kuroha, Takashi, Rao, Arvind, Moriguchi, Takashi, Lim, Kim-Chew, Hosoya, Tomonori, Engel, James Douglas

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Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system by Douglas Engel, James, Lim, Kim-Chew, Lakshmanan, Ganesh, Crawford, Susan E, Gu, Yi, Grosveld, Frank

“…Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin. We recently showed that Gata3-directed lacZ…”
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Proper Development of the Outer Longitudinal Smooth Muscle of the Mouse Pylorus Requires Nkx2-5 and Gata3 by Udager, Aaron M, Prakash, Ajay, Saenz, David A, Schinke, Martina, Moriguchi, Takashi, Jay, Patrick Y, Lim, Kim-Chew, Engel, James Douglas, Gumucio, Deborah L

“…Background & Aims Infantile hypertrophic pyloric stenosis is a common birth anomaly characterized by obstruction of the pyloric lumen. A genome-wide…”
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A Gata2 intronic enhancer confers its pan-endothelia-specific regulation by Khandekar, Melin, Brandt, William, Zhou, Yinghui, Dagenais, Susan, Glover, Thomas W, Suzuki, Norio, Shimizu, Ritsuko, Yamamoto, Masayuki, Lim, Kim-Chew, Engel, James Douglas

“…GATA-2, a transcription factor that has been shown to play important roles in multiple organ systems during embryogenesis, has been ascribed the property of…”
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Transcription factor GATA‐3 is essential for lens development by Maeda, Atsuko, Moriguchi, Takashi, Hamada, Michito, Kusakabe, Manabu, Fujioka, Yuki, Nakano, Takako, Yoh, Keigyou, Lim, Kim‐Chew, Engel, James Douglas, Takahashi, Satoru

“…During vertebrate lens development, the anterior, ectoderm‐derived lens vesicle cells differentiate into a monolayer of epithelial cells that retain…”
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Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity by Ruest, Louis-Bruno, Xiang, Xilin, Lim, Kim-Chew, Levi, Giovanni, Clouthier, David E

“…The lower jaw skeleton is derived from cephalic neural crest (CNC) cells that reside in the mandibular region of the first pharyngeal arch. Endothelin-A…”
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Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation by Moriguchi, Takashi, Takako, Nakano, Hamada, Michito, Maeda, Atsuko, Fujioka, Yuki, Kuroha, Takashi, Huber, Reuben E, Hasegawa, Susan L, Rao, Arvind, Yamamoto, Masayuki, Takahashi, Satoru, Lim, Kim-Chew, Engel, James Douglas

“…Gata3 mutant mice expire of noradrenergic deficiency by embryonic day (E) 11 and can be rescued pharmacologically or, as shown here, by restoring Gata3…”
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UG4 Enhancer-Driven GATA-2 and Bone Morphogenetic Protein 4 Complementation Remedies the CAKUT Phenotype in Gata2 Hypomorphic Mutant Mice by Ainoya, Keiko, Moriguchi, Takashi, Ohmori, Shin'ya, Souma, Tomokazu, Takai, Jun, Morita, Masanobu, Chandler, Kelly J., Mortlock, Douglas P., Shimizu, Ritsuko, Engel, James Douglas, Lim, Kim-Chew, Yamamoto, Masayuki

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Gata2 specifies serotonergic neurons downstream of sonic hedgehog by Craven, Sarah E, Lim, Kim-Chew, Ye, Weilan, Engel, James Douglas, de Sauvage, Frederic, Rosenthal, Arnon

“…Distinct classes of serotonergic (5-HT) neurons develop along the ventral midline of the vertebrate hindbrain. Here, we identify a Sonic hedgehog…”
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Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells by Shi, Lihong, Sierant, M C, Gurdziel, Katherine, Zhu, Fan, Cui, Shuaiying, Kolodziej, Katarzyna E, Strouboulis, John, Guan, Yuanfang, Tanabe, Osamu, Lim, Kim-Chew, Engel, James Douglas

“…We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular…”
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Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT by Hoshino, Tomofumi, Shimizu, Ritsuko, Ohmori, Shinya, Nagano, Masumi, Pan, Xiaoqing, Ohneda, Osamu, Khandekar, Melin, Yamamoto, Masayuki, Lim, Kim-Chew, Engel, James Douglas

“…Constitutive loss of transcription factor GATA-2 leads to embryonic lethality from primitive erythropoietic failure. We serendipitously discovered an essential…”
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