Search Results - "Lim, Grewo"

Gut microbiota is critical for the induction of chemotherapy-induced pain by Shen, Shiqian, Lim, Grewo, You, Zerong, Ding, Weihua, Huang, Peigen, Ran, Chongzhao, Doheny, Jason, Caravan, Peter, Tate, Samuel, Hu, Kun, Kim, Hyangin, McCabe, Michael, Huang, Bo, Xie, Zhongcong, Kwon, Douglas, Chen, Lucy, Mao, Jianren

“…Recent evidence supports a functional connection between gut microbiota and the nervous system. Here the authors show that gut microbiota plays a critical role…”
Get full text

An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve by Ding, Weihua, You, Zerong, Shen, Shiqian, Yang, Jinsheng, Lim, Grewo, Doheny, Jason T, Chen, Lucy, Zhu, Shengmei, Mao, Jianren

“…The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in…”
Get more information

Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain by Ding, Weihua, You, Zerong, Shen, Shiqian, Yang, Jinsheng, Lim, Grewo, Doheny, Jason T, Zhu, Shengmei, Zhang, Yi, Chen, Lucy, Mao, Jianren

“…Orofacial neuropathic pain caused by trigeminal nerve injury is a debilitating condition with limited therapeutic options. Hyperpolarization-activated cyclic…”
Get more information

Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents by Lim, Grewo, Wang, Shuxing, Zhang, Yi, Tian, Yinghong, Mao, Jianren

“…Pain after nerve injury, a phenomenon referred to as neuropathic pain, is a debilitating clinical condition, but the underlying mechanisms remain unclear. As…”
Get full text

Leptin enhances NMDA-induced spinal excitation in rats: A functional link between adipocytokine and neuropathic pain by Tian, Yinghong, Wang, Shuxing, Ma, Yuxin, Lim, Grewo, Kim, Hyangin, Mao, Jianren

“…Recent studies have shown that leptin (an adipocytokine) played an important role in nociceptive behavior induced by nerve injury, but the cellular mechanism…”
Get full text

Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: Role of melatonin and NMDA receptors by Wang, Shuxing, Tian, Yinghong, Song, Li, Lim, Grewo, Tan, Yonghui, You, Zerong, Chen, Lucy, Mao, Jianren

“…The melatonin system dysfunction and the upregulated NMDA receptors in trigeminal nuclei might be involved in trigeminal pain and depression comorbidity. A…”
Get full text

Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the Pathogenesis of Neuropathic Pain in Rats by Sung, Backil, Lim, Grewo, Mao, Jianren

“…The central glutamatergic system has been implicated in the pathogenesis of neuropathic pain, and a highly active central glutamate transporter (GT) system…”
Get full text

Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity by Mao, Jianren, Sung, Backil, Ji, Ru-Rong, Lim, Grewo

“…Tolerance to the analgesic effects of an opioid occurs after its chronic administration, a pharmacological phenomenon that has been associated with the…”
Get full text

Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment by Dai, Jiajia, Kim, Hyangin, You, Zerong, McCabe, Michael F, Zhang, Shuzhuo, Wang, Shiyu, Lim, Grewo, Chen, Lucy, Mao, Jianren

“…The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has…”
Get full text

Morphine Induces Ubiquitin-Proteasome Activity and Glutamate Transporter Degradation by Yang, Liling, Wang, Shuxing, Sung, Backil, Lim, Grewo, Mao, Jianren

“…Glutamate transporters play a crucial role in physiological glutamate homeostasis, neurotoxicity, and glutamatergic regulation of opioid tolerance. However,…”
Get full text

Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats by Li, Na, Lim, Grewo, Chen, Lucy, McCabe, Michael F, Kim, Hyangin, Zhang, Shuzhuo, Mao, Jianren

“…Abstract Previous studies have shown that the morphology and number of cells in the spinal cord dorsal horn could change following peripheral nerve injury and…”
Get full text

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats by Lim, Grewo, Sung, Backil, Ji, Ru-Rong, Mao, Jianren

“…Exogenous cannabinoids are effective in attenuating neuropathic pain behaviors induced by peripheral nerve injury, but the mechanisms of their effectiveness…”
Get full text

Central Glucocorticoid Receptors Modulate the Expression and Function of Spinal NMDA Receptors after Peripheral Nerve Injury by Wang, Shuxing, Lim, Grewo, Zeng, Qing, Sung, Backil, Yang, Liling, Mao, Jianren

“…Central glucocorticoid receptors (GRs) and NMDA receptors (NMDARs) have been shown to play a significant role in the mechanisms of neuropathic pain after…”
Get full text

Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in rats by Wang, Shuxing, Lim, Grewo, Mao, Ji, Sung, Backil, Mao, Jianren

“…Expression of the N-methyl-d-aspartate (NMDA) receptor in trigeminal nuclei has been shown to play a role in the mechanisms of trigeminal pain. Here, we…”
Get full text

Expression of Central Glucocorticoid Receptors after Peripheral Nerve Injury Contributes to Neuropathic Pain Behaviors in Rats by Wang, Shuxing, Lim, Grewo, Zeng, Qing, Sung, Backil, Ai, Yulan, Guo, Gongshe, Yang, Liling, Mao, Jianren

“…Peripheral glucocorticoid receptors (GRs) play a significant role in the anti-inflammatory effects of glucocorticoids; however, the role of central GRs in…”
Get full text

A Functional Relationship Between Trigeminal Astroglial Activation and NR1 Expression in a Rat Model of Temporomandibular Joint Inflammation by Wang, Shuxing, Song, Li, Tan, Yonghui, Ma, Yuxin, Tian, Yinghong, Jin, Xu, Lim, Grewo, Zhang, Shuzhuo, Chen, Lucy, Mao, Jianren

“…Objective To examine the hypothesis that glial activation would regulate the expression of the N‐methyl‐D‐aspartate receptor subunit 1 (NR1) in the trigeminal…”
Get full text

Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats by Sung, Backil, Wang, Shuxing, Zhou, Bei, Lim, Grewo, Yang, Liling, Zeng, Qing, Lim, Jeong-Ae, Wang, Jing Dong, Kang, Jing X., Mao, Jianren

“…Spinal glutamate transporters (GT) have been implicated in the mechanisms of neuropathic pain; however, how spinal GT uptake activity is regulated remains…”
Get full text

cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphine by Lim, Grewo, Wang, Shuxing, Mao, Jianren

“…Our previous study has shown that spinal glutamate transporters (GTs) are downregulated following chronic morphine administration; however, how spinal GTs are…”
Get full text

Downregulation of spinal glutamate transporter EAAC1 followingnerve injury is regulated by central glucocorticoid receptors in rats by Wang, Shuxing, Lim, Grewo, Yang, Liling, Sung, Backil, Mao, Jianren

“…Previous studies have shown that glucocorticoid receptors (GR) were upregulated, whereas glutamate transporters were downregulated, within the spinal cord…”
Get full text

Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability by You, Zerong, Zhang, Shuzhuo, Shen, Shiqian, Yang, Jinsheng, Ding, Weihua, Yang, Liuyue, Lim, Grewo, Doheny, Jason T., Tate, Samuel, Chen, Lucy, Mao, Jianren

“…Clinical evidence indicates that cognitive impairment is a common comorbid condition of chronic pain. However, the cellular basis for chronic pain-mediated…”
Get full text