Search Results - "Lim, Chang Kee"

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain by Lim Kee Chang, William, Chan, Tiffany G., Raguseo, Federica, Mishra, Aishwarya, Chattenton, Dani, de Rosales, Rafael T. M., Long, Nicholas J., Morse, Sophie V.

“…Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics and imaging agents across the blood–brain barrier. Uniform treatment…”
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Current Developments in LC-MS for Pharmaceutical Analysis by Lim, Chang-Kee, Lord, Gwyn

“…The current developments in liquid chromatography-mass spectrometry (LC-MS) and its applications to the analysis of pharmaceuticals are reviewed. Various mass…”
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Cavitation of liquid flow in electrospray mass spectrometry especially for addition of internal calibrant in 'accurate mass' measurements by Lord, Gwyn A., Lim, Chang-Kee

“…‘Accurate mass’ measurements in electrospray mass spectrometry are becoming more prevalent with the increasing availability of mass spectrometers with…”
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Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography/electrospray ionization mass spectrometry by De Matteis, Francesco, Lord, Gwyn A., Kee Lim, Chang, Pons, Nicoletta

“…Bilirubin is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, bilirubin accumulates…”
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Porphomethene inhibitor of uroporphyrinogen decarboxylase: analysis by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry by Danton, Malcolm, Lim, Chang Kee

“…An uroporphomethene inhibitor of uroporphyrinogen decarboxylase, characterized by high‐performance liquid chromatography/electrospray ionization tandem mass…”
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Enantiomeric separation and detection by high-performance liquid chromatography-mass spectrometry of 2-arylpropionic acids derivatized with benzofurazan fluorescent reagents by Santa, Tomofumi, Luo, Jinli, Lim, Chang-Kee, Imai, Kuzuhiro

“…The enantiomneric separation and the detection of 2‐arylpropionic acids after derivatization with the fluorescent reagents with a benzofurazan structure,…”
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Ultra high-performance liquid chromatography of porphyrins by Benton, Christopher M., Lim, Chang Kee, Ritchie, Harald J., Moniz, Caje, Jones, Donald J.L.

“…ABSTRACT An ultra high‐performance liquid chromatographic (UHPLC) system was developed and optimized for the separation of porphyrins of clinical interest…”
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Dihydroxy-, Hydroxyspirolactone-, and Dihydroxyspirolactone-urochlorins Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Liver of Mice by Lim, Chang-Kee, Danton, Malcolm, Clothier, Bruce, Smith, Andrew G.

“…Previous work has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes porphyria, enhanced by iron, in C57BL/6J mice with marked accumulation in the…”
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Characterization of Heparin Oligosaccharide Mixtures as Ammonium Salts Using Electrospray Mass Spectrometry by Chai, Wengang, Luo, Jinli, Lim, Chang Kee, Lawson, Alexander M

“…Among glycosaminoglycans, polysulfated heparin chains provide the greatest challenge to characterization due to high polarity, structural diversity, and…”
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Capillary electrochromatographic analysis of barbiturates in serum by Ohyama, Kaname, Wada, Mitsuhiro, Lord, Gwyn A., Ohba, Yoshihito, Fujishita, Osamu, Nakashima, Kenichiro, Lim, Chang Kee, Kuroda, Naotaka

“…A capillary electrochromatographic method was developed for the separation of barbiturates. The separation was optimized in a 75 μm ID capillary, packed with…”
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Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities by Smith, Lewis L., Brown, Karen, Carthew, Philip, Lim, Chang-Kee, Martin, Elizabeth A., Styles, Jerry, White, Ian N. H.

“…ABSTRACT The antiestrogen tamoxifen is widely used in the adjuvant therapy of breast cancers in women and helps to prevent the occurrence of breast tumors in…”
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A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes by Lim, C K, Yuan, Z X, Lamb, J H, White, I N, De Matteis, F, Smith, L L

“…The metabolisms of tamoxifen in female rat, mouse and human liver microsomal preparations were compared. Rat, mouse and human liver microsomes were incubated…”
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Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism by Smith, A G, Clothier, B, Robinson, S, Scullion, M J, Carthew, P, Edwards, R, Luo, J, Lim, C K, Toledano, M

“…The binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with the aryl hydrocarbon (AH) receptor and subsequent changes in gene expression have been studied…”
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Microbubble dynamics in brain microvessels at 1 MHz and 330 kHz driving frequencies by Bezer, James H., Prentice, Paul, Lim Kee Chang, William, Jiang, Zheng, Morse, Sophie, Rowlands, Christopher, Christensen-Jeffries, Kirsten M., Kozlov, Andrei, Choi, James

“…Blood-brain barrier (BBB) disruption using ultrasound-driven microbubbles is a promising technique to deliver drugs to the brain. This study aimed to directly…”
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Effect of drug-light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma by Ris, H B, Altermatt, H J, Nachbur, B, Stewart, J C, Wang, Q, Lim, C K, Bonnett, R, Althaus, U

“…The influence of the time interval (TI) between drug administration and laser activation on selectivity of meta-tetrahydroxyphenylchlorin(mTHPC)-mediated…”
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Reminiscences of Chang Kee Lim

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Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts by Davies, A M, Martin, E A, Jones, R M, Lim, C K, Smith, L L, White, I N

“…When [14C]tamoxifen was incubated with horseradish peroxidase and H2O2, two major metabolites, separated and identified by HPLC, were N-desmethyltamoxifen and…”
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Species differences in the covalent binding of [ 14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved by White, Ian N.H., De Matteis, Francesco, Gibbs, Anthony H., Lim, Chang Kee, Wolf, C.Roland, Henderson, Colin, Smith, Lewis L.

“…Species differences in the NADPH-dependent covalent binding of [ 14C]tamoxifen to liver microsomes have been studied using preparations from humans, female…”
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Porphyrin profiles in blood, urine and faeces by HPLC/electrospray ionization tandem mass spectrometry by Danton, Malcolm, Lim, Chang Kee

“…A high‐resolution high‐performance liquid chromatography/electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry method is described for the…”
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Structural analysis of haemin demetallation by L-chain apoferritins by de Val, Natalia, Declercq, Jean-Paul, Lim, Chang Kee, Crichton, Robert R.

“…There are extensive structural similarities between eukaryotic and prokaryotic ferritins. However, there is one essential difference between these two types of…”
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