Search Results - "Lim, Cadmon"

Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis by Cheng, Feifei, Luk, Andrea O, Shi, Mai, Huang, Chuiguo, Jiang, Guozhi, Yang, Aimin, Wu, Hongjiang, Lim, Cadmon K P, Tam, Claudia H T, Fan, Baoqi, Lau, Eric S H, Ng, Alex C W, Wong, Kwun Kiu, Carroll, Luke, Lee, Heung Man, Kong, Alice P, Keech, Anthony C, Chow, Elaine, Joglekar, Mugdha V, Tsui, Stephen K W, So, Wing Yee, So, Hon Cheong, Hardikar, Anandwardhan A, Jenkins, Alicia J, Chan, Juliana C N, Ma, Ronald C W

“…Several studies support associations between relative leukocyte telomere length (rLTL), a biomarker of biological aging and type 2 diabetes. This study…”
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Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes by Chow, Elaine, Wang, Ke, Lim, Cadmon K P, Tsoi, Sandra T F, Fan, Baoqi, Poon, Emily, Luk, Andrea O Y, Ma, Ronald C W, Ferrannini, Ele, Mari, Andrea, Chen, Li, Chan, Juliana C N

“…Glucokinase (GK, gene symbol GCK) maturity-onset diabetes of the young (MODY) is caused by heterozygous inactivating mutations in GK and impaired glucose…”
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Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register by Cheng, Feifei, Luk, Andrea O, Tam, Claudia H T, Fan, Baoqi, Wu, Hongjiang, Yang, Aimin, Lau, Eric S H, Ng, Alex C W, Lim, Cadmon K P, Lee, Heung Man, Chow, Elaine, Kong, Alice P, Keech, Anthony C, Joglekar, Mugdha V, So, Wing Yee, Jenkins, Alicia J, Chan, Juliana C N, Hardikar, Anandwardhan A, Ma, Ronald C W

“…Several studies support potential links between relative leukocyte telomere length (rLTL), a biomarker of biological aging, and type 2 diabetes. This study…”
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Comparison of β-Cell Function and Insulin Sensitivity Between Normal-Weight and Obese Chinese With Young-Onset Type 2 Diabetes by Fan, Yingnan, Chow, Elaine, Lim, Cadmon K P, Hou, Yong, Tsoi, Sandra T F, Fan, Baoqi, Lau, Eric S H, Kong, Alice P S, Ma, Ronald C W, Wu, Hongjiang, Chan, Juliana C N, Luk, Andrea O Y

“…Normal-weight individuals with usual-onset type 2 diabetes have reduced β-cell function and greater insulin sensitivity compared with their obese counterparts…”
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Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register by Cheng, Feifei, Luk, Andrea O., Wu, Hongjiang, Tam, Claudia H. T., Lim, Cadmon K. P., Fan, Baoqi, Jiang, Guozhi, Carroll, Luke, Yang, Aimin, Lau, Eric S. H., Ng, Alex C. W., Lee, Heung Man, Chow, Elaine, Kong, Alice P. S., Keech, Anthony C., Joglekar, Mugdha V., So, Wing Yee, Hardikar, Anandwardhan A., Chan, Juliana C. N., Jenkins, Alicia J., Ma, Ronald C. W.

“…Aims/hypothesis Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in…”
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Lessons and Applications of Omics Research in Diabetes Epidemiology by Yu, Gechang, Tam, Henry C. H., Huang, Chuiguo, Shi, Mai, Lim, Cadmon K. P., Chan, Juliana C. N., Ma, Ronald C. W.

“…Purpose of Review Recent advances in genomic technology and molecular techniques have greatly facilitated the identification of disease biomarkers, advanced…”
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Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank by Jin, Qiao, Lau, Eric S. H., Luk, Andrea O., Tam, Claudia H. T., Ozaki, Risa, Lim, Cadmon K. P., Wu, Hongjiang, Chow, Elaine Y. K., Kong, Alice P. S., Lee, Heung Man, Fan, Baoqi, Ng, Alex C. W., Jiang, Guozhi, Lee, Ka Fai, Siu, Shing Chung, Hui, Grace, Tsang, Chiu Chi, Lau, Kam Piu, Leung, Jenny Y., Tsang, Man-wo, Cheung, Elaine Y. N., Kam, Grace, Lau, Ip Tim, Li, June K., Yeung, Vincent T. F., Lau, Emmy, Lo, Stanley, Fung, Samuel, Cheng, Yuk Lun, Chow, Chun Chung, Yu, Weichuan, Tsui, Stephen K. W., Tomlinson, Brian, Huang, Yu, Lan, Hui-yao, Szeto, Cheuk Chun, So, Wing Yee, Jenkins, Alicia J., Fung, Erik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Chan, Juliana C. N., Ma, Ronald C. W.

“…Aims/hypothesis The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes,…”
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Differential Associations of GAD Antibodies (GADA) and C-Peptide With Insulin Initiation, Glycemic Responses, and Severe Hypoglycemia in Patients Diagnosed With Type 2 Diabetes by Fan, Baoqi, Lim, Cadmon K P, Poon, Emily W M, Lau, Eric S H, Wu, Hongjiang, Yang, Aimin, Shi, Mai, Tam, Claudia H T, Wong, Samuel Y S, Lee, Eric Kam-Pui, Wang, Maggie H T, Chu, Natural H S, Ozaki, Risa, Kong, Alice P S, Chow, Elaine, Ma, Ronald C W, Luk, Andrea O Y, Chan, Juliana C N

“…We examined the associations of GAD antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses, and severe hypoglycemia in type 2…”
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Vitamin D Levels During Pregnancy Are Associated With Offspring Telomere Length: A Longitudinal Mother-Child Study by Wong, Kwun Kiu, Cheng, Feifei, Mao, Di, Lim, Cadmon K P, Tam, Claudia H T, Wang, Chi Chiu, Yuen, Lai Yuk, Chan, Michael H M, Ho, Chung Shun, Joglekar, Mugdha V, Hardikar, Anandwardhan A, Jenkins, Alicia J, Metzger, Boyd E, Lowe, William L, Tam, Wing Hung, Ma, Ronald C W

“…Leukocyte telomere length (LTL) is a biomarker of biological aging and is associated with metabolic diseases such as type 2 diabetes. Insufficient maternal…”
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Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children's glucose metabolism-a longitudinal study by Wong, Kwun Kiu, Cheng, Feifei, Lim, Cadmon K P, Tam, Claudia H T, Tutino, Greg, Yuen, Lai Yuk, Wang, Chi Chiu, Hou, Yong, Chan, Michael H M, Ho, Chung Shun, Joglekar, Mugdha V, Hardikar, Anandwardhan A, Jenkins, Alicia J, Metzger, Boyd E, Lowe, Jr, William L, Tam, Wing Hung, Ma, Ronald C W

“…Leukocyte telomere length (LTL) is suggested to be a biomarker of biological age and reported to be associated with metabolic diseases such as type 2 diabetes…”
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Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank by Jiang, Guozhi, Luk, Andrea O, Tam, Claudia H. T, Lau, Eric S, Ozaki, Risa, Chow, Elaine Y. K, Kong, Alice P. S, Lim, Cadmon K. P, Lee, Ka Fai, Siu, Shing Chung, Hui, Grace, Tsang, Chiu Chi, Lau, Kam Piu, Leung, Jenny Y. Y, Tsang, Man-wo, Kam, Grace, Lau, Ip Tim, Li, June K, Yeung, Vincent T, Lau, Emmy, Lo, Stanley, Fung, Samuel K. S, Cheng, Yuk Lun, Chow, Chun Chung, Pearson, Ewan R, So, Wing Yee, Chan, Juliana C. N, Ma, Ronald C. W

“…Background Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is…”
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Comparison of beta-cell function between Hong Kong Chinese with young-onset type 2 diabetes and late-onset type 2 diabetes by Fan, Yingnan, Fan, Baoqi, Lau, Eric S.H., Lim, Cadmon K.P., Wu, Hongjiang, Ma, Ronald C.W., Ozaki, Risa, Kong, Alice P.S., Chow, Elaine, Luk, Andrea O.Y., Chan, Juliana C.N.

“…We compared beta-cell function in Chinese with type 2 diabetes diagnosed at age < 40 years (young-onset diabetes, YOD) and ≥ 40 years (late-onset diabetes,…”
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Nonalbuminuric Diabetic Kidney Disease and Risk of All-Cause Mortality and Cardiovascular and Kidney Outcomes in Type 2 Diabetes: Findings From the Hong Kong Diabetes Biobank by Jin, Qiao, Luk, Andrea O, Lau, Eric S H, Tam, Claudia H T, Ozaki, Risa, Lim, Cadmon K P, Wu, Hongjiang, Jiang, Guozhi, Chow, Elaine Y K, Ng, Jack K, Kong, Alice P S, Fan, Baoqi, Lee, Ka Fai, Siu, Shing Chung, Hui, Grace, Tsang, Chiu Chi, Lau, Kam Piu, Leung, Jenny Y, Tsang, Man-Wo, Kam, Grace, Lau, Ip Tim, Li, June K, Yeung, Vincent T, Lau, Emmy, Lo, Stanley, Fung, Samuel, Cheng, Yuk Lun, Chow, Chun Chung, Huang, Yu, Lan, Hui-Yao, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C N, Ma, Ronald C W

“…Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing DKD phenotype. We compared the risks of adverse outcomes among patients with this…”
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Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank by Jin, Qiao, Lau, Eric S.H., Luk, Andrea O.Y., Ozaki, Risa, Chow, Elaine Y.K., Cheng, Feifei, So, Tammy, Yeung, Theresa, Loo, Kit-man, Lim, Cadmon K.P., Kong, Alice P.S., Jenkins, Alicia J., Chan, Juliana C.N., Ma, Ronald C.W.

“…To investigate association between skin autofluorescence (SAF) and cardiovascular events (CVE) and assess its predictive value in Chinese adults with type 2…”
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Associations of the HOMA2‐%B and HOMA2‐IR with progression to diabetes and glycaemic deterioration in young and middle‐aged Chinese by Fan, Baoqi, Wu, Hongjiang, Shi, Mai, Yang, Aimin, Lau, Eric S. H., Tam, Claudia H. T., Mao, Dandan, Lim, Cadmon K. P., Kong, Alice P. S., Ma, Ronald C. W., Chow, Elaine, Luk, Andrea O. Y., Chan, Juliana C. N.

“…Aims Insulin deficiency (ID) and resistance (IR) contribute to progression from normal glucose tolerance to diabetes to insulin requirement although their…”
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CYP2C19 Loss‐of‐function Polymorphisms are Associated with Reduced Risk of Sulfonylurea Treatment Failure in Chinese Patients with Type 2 Diabetes by Wang, Ke, Yang, Aimin, Shi, Mai, Tam, Claudia C. H., Lau, Eric S. H., Fan, Baoqi, Lim, Cadmon K. P., Lee, Heung Man, Kong, Alice P. S., Luk, Andrea O. Y., Tomlinson, Brian, Ma, Ronald C. W., Chan, Juliana C. N., Chow, Elaine

“…Sulfonylureas (SUs) are predominantly metabolized by cytochrome p450 2C9 (CYP2C9) and cytochrome p450 2C19 (CYP2C19) enzymes. CYP2C9 polymorphisms are…”
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Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes by Jiang, Guozhi, Luk, Andrea O, Tam, Claudia H T, Ozaki, Risa, Lim, Cadmon K P, Chow, Elaine Y K, Lau, Eric S, Kong, Alice P S, Fan, Baoqi, Lee, Ka Fai, Siu, Shing Chung, Hiu, Grace, Tsang, Chiu Chi, Lau, Kam Piu, Leung, Jenny Y, Tsang, Man-wo, Kam, Grace, Lau, Ip Tim, Li, June K, Yeung, Vincent T, Lau, Emmy, Lo, Stanley, Fung, Samuel, Cheng, Yuk Lun, Chow, Chun Chung, Tang, Nelson L S, Huang, Yu, Lan, Hui-yao, Oram, Richard A, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C N, Ma, Ronald C W

“…We aim to assess the long-term impact of acute kidney injury (AKI) on progression of diabetic kidney disease (DKD) and all-cause mortality and investigate…”
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1274-P: Prevalence and Clinical Characteristics of Monogenic Diabetes in Chinese Population by TSOI, SANDRA, LIM, CADMON K., MA, RONALD C., LAU, ERIC S., FAN, BAOQI, CHOW, ELAINE, KONG, ALICE P., CHAN, JULIANA C., LUK, ANDREA

“…Background: Prognosis of monogenic diabetes in Chinese is not well reported. We identified pathogenic mutations in monogenic diabetes genes in a prospective…”
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1829-PUB: Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes Randomised Controlled Trial (PRISM-RCT) in Chinese Patients with Young-Onset Diabetes—Study Design and Baseline Profile by LUK, ANDREA, FAN, YINGNAN, FAN, BAOQI, LIM, CADMON K.P., LAU, ERIC S.H., POON, EMILY W.M., TSOI, SANDRA T.F., OZAKI, RISA, MA, RONALD C., CHOW, ELAINE, KONG, ALICE P., CHAN, JULIANA C.

“…Background: Young-onset diabetes (YOD) is heterogenous in aetiologies and clinical phenotypes. The PRISM study is a 3-year randomised controlled trial to…”
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1472-P: Polygenic Risk Score for Liver Fat Predicts Earlier Onset of Type 2 Diabetes in an East Asian Population by YU, GECHANG, MA, RONALD C., TAM, CLAUDIA H., SHI, MAI, FAN, BAOQI, LIM, CADMON K., CHAN, JULIANA C., WEEDON, MICHAEL N., ORAM, RICHARD A., HUANG, CHUIGUO, LUK, ANDREA, LAU, ERIC S.H.

“…Liver, pancreas fat deposition and volume have been associated with type 2 diabetes (T2D) risk by Mendelian randomization study. However, it is unknown whether…”
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