Search Results - "Lim, A."

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module by Toettcher, Jared E., Weiner, Orion D., Lim, Wendell A.

“…The complex, interconnected architecture of cell-signaling networks makes it challenging to disentangle how cells process extracellular information to make…”
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Secreting and Sensing the Same Molecule Allows Cells to Achieve Versatile Social Behaviors by Youk, Hyun, Lim, Wendell A.

“…Cells that secrete and sense the same signaling molecule are ubiquitous. To uncover the functional capabilities of the core "secrete-and-sense" circuit motif…”
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High-throughput multicolor optogenetics in microwell plates by Bugaj, Lukasz J., Lim, Wendell A.

“…Optogenetic probes can be powerful tools for dissecting complexity in cell biology, but there is a lack of instrumentation to exploit their potential for…”
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Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information by Good, Matthew C., Zalatan, Jesse G., Lim, Wendell A.

“…The spatial and temporal organization of molecules within a cell is critical for coordinating the many distinct activities carried out by the cell. In an…”
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Cysteine‐Rich Peptides: Hyperstable Scaffolds for Protein Engineering by González‐Castro, Rafael, Gómez‐Lim, Miguel A., Plisson, Fabien

“…Cysteine‐rich peptides (CRPs) are small proteins of less than 100 amino acids in length characterized by the presence of disulfide bridges and common…”
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Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression by Qi, Lei S., Larson, Matthew H., Gilbert, Luke A., Doudna, Jennifer A., Weissman, Jonathan S., Arkin, Adam P., Lim, Wendell A.

“…Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a…”
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Constraining the top-quark mass within the global MSHT PDF fit by Cridge, Thomas, Lim, Matthew A.

“…We examine the ability of experimental measurements of top-quark pair production to constrain both the top-quark mass and the strong coupling within the global…”
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CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells by Rupp, Levi J., Schumann, Kathrin, Roybal, Kole T., Gate, Rachel E., Ye, Chun J., Lim, Wendell A., Marson, Alexander

“…Immunotherapies with chimeric antigen receptor (CAR) T cells and checkpoint inhibitors (including antibodies that antagonize programmed cell death protein 1…”
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Therapeutic Benefit of Autophagy Modulation in Pompe Disease by Lim, Jeong-A, Sun, Baodong, Puertollano, Rosa, Raben, Nina

“…The complexity of the pathogenic cascade in lysosomal storage disorders suggests that combination therapy will be needed to target various aspects of…”
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Cell-based therapeutics: the next pillar of medicine by Fischbach, Michael A, Bluestone, Jeffrey A, Lim, Wendell A

“…Two decades ago, the pharmaceutical industry-long dominated by small-molecule drugs-was revolutionized by the the advent of biologics. Today, biomedicine sits…”
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Molecular Identity of Human Outer Radial Glia during Cortical Development by Pollen, Alex A., Nowakowski, Tomasz J., Chen, Jiadong, Retallack, Hanna, Sandoval-Espinosa, Carmen, Nicholas, Cory R., Shuga, Joe, Liu, Siyuan John, Oldham, Michael C., Diaz, Aaron, Lim, Daniel A., Leyrat, Anne A., West, Jay A., Kriegstein, Arnold R.

“…Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer…”
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Systematic Functional Prioritization of Protein Posttranslational Modifications by Beltrao, Pedro, Albanèse, Véronique, Kenner, Lillian R., Swaney, Danielle L., Burlingame, Alma, Villén, Judit, Lim, Wendell A., Fraser, James S., Frydman, Judith, Krogan, Nevan J.

“…Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential…”
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Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans by Chen, Witney, de Hemptinne, Coralie, Miller, Andrew M., Leibbrand, Michael, Little, Simon J., Lim, Daniel A., Larson, Paul S., Starr, Philip A.

“…The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway…”
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CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes by Gilbert, Luke A., Larson, Matthew H., Morsut, Leonardo, Liu, Zairan, Brar, Gloria A., Torres, Sandra E., Stern-Ginossar, Noam, Brandman, Onn, Whitehead, Evan H., Doudna, Jennifer A., Lim, Wendell A., Weissman, Jonathan S., Qi, Lei S.

“…The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The…”
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High carbon emissions from thermokarst lakes of Western Siberia by Serikova, S., Pokrovsky, O. S., Laudon, H., Krickov, I. V., Lim, A. G., Manasypov, R. M., Karlsson, J.

“…The Western Siberia Lowland (WSL), the world’s largest permafrost peatland, is of importance for understanding the high-latitude carbon (C) cycle and its…”
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The mediating and moderating role of recovery experience between occupational stress and turnover intention in nurses caring for patients with COVID‐19 by Lee, Junghoon, Kim, Junekyu, Lim, Hong‐A, Song, Yeoungsuk

“…Aim This study aimed to investigate the relationships among occupational stress, recovery experience and turnover intention among nurses caring for patients…”
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Network-Compute Co-Optimization for Service Chaining in Cloud-Edge-Radio 5G Networks by Kim, Yeongjin, Choi, Pyeongjun, Lim, Jeong-A, Kwak, Jeongho

“…Flexible resource management can be facilitated by recent drastic advances in software-defined networking (SDN) and network function virtualization (NFV)…”
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Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network by Mitchell, Amir, Wei, Ping, Lim, Wendell A.

“…Cells must interpret environmental information that often changes over time. In our experiment, we systematically monitored the growth of yeast cells under…”
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Neural activity promotes long-distance, target-specific regeneration of adult retinal axons by Lim, Jung-Hwan A, Stafford, Benjamin K, Nguyen, Phong L, Lien, Brian V, Wang, Chen, Zukor, Katherine, He, Zhigang, Huberman, Andrew D

“…A combination of increased neural activity, induced by visual stimulation or using chemogenetics, and increasing mTOR signaling promotes retinal ganglion cell…”
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Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits by Roybal, Kole T., Rupp, Levi J., Morsut, Leonardo, Walker, Whitney J., McNally, Krista A., Park, Jason S., Lim, Wendell A.

“…T cells can be re-directed to kill cancer cells using chimeric antigen receptors (CARs) or T cell receptors (TCRs). This approach, however, is constrained by…”
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