Search Results - "Lillycrop, Karen A"

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease by Burdge, Graham C, Lillycrop, Karen A

“…There is considerable evidence for induction of differential risk of noncommunicable diseases in humans by variation in the quality of the early life…”
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Epigenetic mechanisms linking early nutrition to long term health by Lillycrop, Karen A, Burdge, Graham C

“…Traditionally it has been widely accepted that our genes together with adult lifestyle factors determine our risk of developing non-communicable diseases such…”
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Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial by Antoun, Elie, Kitaba, Negusse T, Titcombe, Philip, Dalrymple, Kathryn V, Garratt, Emma S, Barton, Sheila J, Murray, Robert, Seed, Paul T, Holbrook, Joanna D, Kobor, Michael S, Lin, David Ts, MacIsaac, Julia L, Burdge, Graham C, White, Sara L, Poston, Lucilla, Godfrey, Keith M, Lillycrop, Karen A

“…Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes,…”
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Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring by Lillycrop, Karen A, Phillips, Emma S, Jackson, Alan A, Hanson, Mark A, Burdge, Graham C

“…Environmental constraints during early life result in phenotypic changes that can be associated with increased disease risk in later life. This suggests…”
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Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease by Godfrey, Keith M, Lillycrop, Karen A, Burdge, Graham C, Gluckman, Peter D, Hanson, Mark A

“…There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that…”
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Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations by Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.

“…Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and…”
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Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells by Hoile, Samuel P, Clarke-Harris, Rebecca, Huang, Rae-Chi, Calder, Philip C, Mori, Trevor A, Beilin, Lawrence J, Lillycrop, Karen A, Burdge, Graham C

“…Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no…”
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Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition by Burdge, Graham C, Lillycrop, Karen A, Phillips, Emma S, Slater-Jefferies, Joanne L, Jackson, Alan A, Hanson, Mark A

“…Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adulthood contingent on adult diet. In rats, folic acid…”
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Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? by Burdge, Graham C., Hanson, Mark A., Slater-Jefferies, Jo L., Lillycrop, Karen A.

“…There is considerable evidence for the induction of different phenotypes by variations in the early life environment, including nutrition, which in man is…”
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Modification of subcutaneous white adipose tissue inflammation by omega-3 fatty acids is limited in human obesity-a double blind, randomised clinical trial by Fisk, Helena L, Childs, Caroline E, Miles, Elizabeth A, Ayres, Robert, Noakes, Paul S, Paras-Chavez, Carolina, Kuda, Ondrej, Kopecký, Jan, Antoun, Elie, Lillycrop, Karen A, Calder, Philip C

“…Obesity is associated with enhanced inflammation. However, investigation in human subcutaneous white adipose tissue (scWAT) is limited and the mechanisms by…”
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Metabolic plasticity during mammalian development is directionally dependent on early nutritional status by Gluckman, Peter D, Lillycrop, Karen A, Vickers, Mark H, Pleasants, Anthony B, Phillips, Emma S, Beedle, Alan S, Burdge, Graham C, Hanson, Mark A

“…Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently…”
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DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood by Issarapu, Prachand, Arumalla, Manisha, Elliott, Hannah R., Nongmaithem, Suraj S., Sankareswaran, Alagu, Betts, Modupeh, Sajjadi, Sara, Kessler, Noah J., Bayyana, Swati, Mansuri, Sohail R., Derakhshan, Maria, Krishnaveni, G. V., Shrestha, Smeeta, Kumaran, Kalyanaraman, Di Gravio, Chiara, Sahariah, Sirazul A., Sanderson, Eleanor, Relton, Caroline L., Ward, Kate A., Moore, Sophie E., Prentice, Andrew M., Lillycrop, Karen A., Fall, Caroline H. D., Silver, Matt J., Chandak, Giriraj R.

“…Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income…”
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Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition by Burdge, Graham C, Hoile, Samuel P, Uller, Tobias, Thomas, Nicola A, Gluckman, Peter D, Hanson, Mark A, Lillycrop, Karen A

“…Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between…”
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Multigenerational diabetes mellitus by Thornton, Jennifer M, Shah, Nishel M, Lillycrop, Karen A, Cui, Wei, Johnson, Mark R, Singh, Natasha

“…Gestational diabetes (GDM) changes the maternal metabolic and uterine environment, thus increasing the risk of short- and long-term adverse outcomes for both…”
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Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver by Hoile, Samuel P, Irvine, Nicola A, Kelsall, Christopher J, Sibbons, Charlene, Feunteun, Aurélie, Collister, Alex, Torrens, Christopher, Calder, Philip C, Hanson, Mark A, Lillycrop, Karen A, Burdge, Graham C

“…Poor prenatal nutrition, acting through epigenetic processes, induces persistent changes in offspring phenotype. We investigated the effect of maternal fat…”
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Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial by Fisk, Helena L., Childs, Caroline E., Miles, Elizabeth A., Ayres, Robert, Noakes, Paul S., Paras-Chavez, Carolina, Antoun, Elie, Lillycrop, Karen A., Calder, Philip C.

“…Background Obesity is associated with enhanced lipid accumulation and the expansion of adipose tissue accompanied by hypoxia and inflammatory signalling…”
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Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes by West, Annette L., Michaelson, Louise V., Miles, Elizabeth A., Haslam, Richard P., Lillycrop, Karen A., Georgescu, Ramona, Han, Lihua, Napier, Johnathan A., Calder, Philip C., Burdge, Graham C.

“…The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n‐6 and 22:6n‐3…”
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Oxylipin secretion by human CD3 + T lymphocytes in vitro is modified by the exogenous essential fatty acid ratio and life stage by von Gerichten, Johanna, West, Annette L, Irvine, Nicola A, Miles, Elizabeth A, Calder, Philip C, Lillycrop, Karen A, Burdge, Graham C, Fielding, Barbara A

“…Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger…”
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Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring by Hoile, Samuel P, Lillycrop, Karen A, Thomas, Nicola A, Hanson, Mark A, Burdge, Graham C

“…There is considerable evidence for non-genomic transmission between generations of phenotypes induced by environmental exposures during development, although…”
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Fatty acid composition and metabolic partitioning of α-linolenic acid are contingent on life stage in human CD3 + T lymphocytes by West, Annette L, von Gerichten, Johanna, Irvine, Nicola A, Miles, Elizabeth A, Lillycrop, Karen A, Calder, Philip C, Fielding, Barbara A, Burdge, Graham C

“…Immune function changes across the life course; the fetal immune system is characterised by tolerance while that of seniors is less able to respond effectively…”
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