Leading indicators of mosquito-borne disease elimination

Leading indicators of mosquito-borne disease elimination

Mosquito-borne diseases contribute significantly to the global disease burden. High-profile elimination campaigns are currently underway for many parasites, e.g., Plasmodium spp., the causal agent of malaria. Sustaining momentum near the end of elimination programs is often difficult to achieve and...

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Bibliographic Details
Published in:Theoretical ecology Vol. 9; no. 3; pp. 269 - 286
Main Authors: O’Regan, Suzanne M., Lillie, Jonathan W., Drake, John M.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-09-2016
Springer Nature B.V
Subjects:
Aquatic insects
Biomedical and Life Sciences
Coefficient of variation
Culicidae
Disease control
Disease management
Infectious diseases
Life Sciences
Malaria
Mosquitoes
Original Paper
Parasites
Plant Sciences
Plasmodium
Theoretical Ecology/Statistics
Vector-borne diseases
Zoology
Transcritical bifurcation
Malaria
Vector-borne disease model
Disease elimination
Critical transition
Vector-borne disease
Critical slowing down
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Summary:Mosquito-borne diseases contribute significantly to the global disease burden. High-profile elimination campaigns are currently underway for many parasites, e.g., Plasmodium spp., the causal agent of malaria. Sustaining momentum near the end of elimination programs is often difficult to achieve and consequently quantitative tools that enable monitoring the effectiveness of elimination activities after the initial reduction of cases has occurred are needed. Documenting progress in vector-borne disease elimination is a potentially important application for the theory of critical transitions. Non-parametric approaches that are independent of model-fitting would advance infectious disease forecasting significantly. In this paper, we consider compartmental Ross-McDonald models that are slowly forced through a critical transition through gradually deployed control measures. We derive expressions for the behavior of candidate indicators, including the autocorrelation coefficient, variance, and coefficient of variation in the number of human cases during the approach to elimination. We conducted a simulation study to test the performance of each summary statistic as an early warning system of mosquito-borne disease elimination. Variance and coefficient of variation were highly predictive of elimination but autocorrelation performed poorly as an indicator in some control contexts. Our results suggest that tipping points (bifurcations) in mosquito-borne infectious disease systems may be foreshadowed by characteristic temporal patterns of disease prevalence.
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ISSN:1874-1738
1874-1746
DOI:10.1007/s12080-015-0285-5