Search Results - "Lill, Claire L."

Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) by Rewcastle, Gordon W, Gamage, Swarna A, Flanagan, Jack U, Frederick, Raphael, Denny, William A, Baguley, Bruce C, Kestell, Philip, Singh, Ripudaman, Kendall, Jackie D, Marshall, Elaine S, Lill, Claire L, Lee, Woo-Jeong, Kolekar, Sharada, Buchanan, Christina M, Jamieson, Stephen M. F, Shepherd, Peter R

“…A structure–activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor…”
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Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors by Kendall, Jackie D., Giddens, Anna C., Tsang, Kit Yee, Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Jamieson, Stephen M.F., Rewcastle, Gordon W., Baguley, Bruce C., Denny, William A., Shepherd, Peter R.

“…[Display omitted] As part of our investigation into pyrazolo[1,5-a]pyridines as novel p110α selective PI3 kinase inhibitors, we report a range of analogues…”
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Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling by Marshall, Andrew J., Lill, Claire L., Chao, Mindy, Kolekar, Sharada V., Lee, Woo-Jeong, Marshall, Elaine S., Baguley, Bruce C., Shepherd, Peter R., Denny, William A., Flanagan, Jack U., Rewcastle, Gordon W.

“…[Display omitted] A novel series of TGX-221 analogues was prepared and tested for their potency against the p110α, p110β, and p110δ isoforms of the PI3K…”
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Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR by Kendall, Jackie D., Giddens, Anna C., Tsang, Kit Yee, Frédérick, Raphaël, Marshall, Elaine S., Singh, Ripudaman, Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W., Baguley, Bruce C., Flanagan, Jack U., Jamieson, Stephen M.F., Denny, William A., Shepherd, Peter R.

“…Structure–activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and…”
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Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors by Kendall, Jackie D., O’Connor, Patrick D., Marshall, Andrew J., Frédérick, Raphaël, Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W., Baguley, Bruce C., Flanagan, Jack U., Jamieson, Stephen M.F., Denny, William A., Shepherd, Peter R.

“…We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class…”
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Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) by Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Kendall, Jackie D., Denny, William A., Baguley, Bruce C., Buchanan, Christina M., Chao, Mindy, Kestell, Philip, Kolekar, Sharada, Lee, Woo-Jeong, Lill, Claire L., Malik, Alisha, Singh, Ripudaman, Jamieson, Stephen M.F., Shepherd, Peter R.

“…A range of 4-substituted derivatives of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di-(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole…”
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Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474) by Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Frederick, Raphael, Denny, William A., Baguley, Bruce C., Kestell, Philip, Singh, Ripudaman, Kendall, Jackie D., Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Buchanan, Christina M., Jamieson, Stephen M. F., Shepherd, Peter R.

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Novel pyrazolo[1,5-a]pyridines as p110I+/--selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR by Kendall, Jackie D, Giddens, Anna C, Tsang, Kit Yee, Frederick, Raphaeel, Marshall, Elaine S, Singh, Ripudaman, Lill, Claire L, Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W, Baguley, Bruce C, Flanagan, Jack U, Jamieson, Stephen MF, Denny, William A, Shepherd, Peter R

“…Structure-activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and…”
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Discovery of pyrazolo[1,5-a]pyridines as p110I+/--selective PI3 kinase inhibitors by Kendall, Jackie D, O'Connor, Patrick D, Marshall, Andrew J, Frederick, Raphaeel, Marshall, Elaine S, Lill, Claire L, Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W, Baguley, Bruce C, Flanagan, Jack U, Jamieson, Stephen MF, Denny, William A, Shepherd, Peter R

“…We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110 alpha isoform over the other…”
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