Search Results - "Liliemark, J."

Outcomes associated with higher relational continuity in the treatment of persons with asthma or chronic obstructive pulmonary disease: A systematic review by Lytsy, Per, Engström, Sven, Ekstedt, Mirjam, Engström, Ingemar, Hansson, Lars, Ali, Lilas, Fredriksson, Maja Kärrman, Liliemark, Jan, Berg, Jenny

“…Asthma and chronic obstructive pulmonary disease (COPD) are chronic conditions where relational continuity of care, as in regularly meeting the same health…”
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Should regulators be concerned with pharmacoeconomic issues? by Liliemark, J

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P-Glycoprotein Inhibitor Valspodar (PSC 833) Increases the Intracellular Concentrations of Daunorubicin In Vivo in Patients With P-Glycoprotein–Positive Acute Myeloid Leukemia by TIDEFELT, U, LILIEMARK, J, XU, D, COVELLI, A, GUSTAVSSON, B, PAUL, C, GRUBER, A, LILIEMARK, E, SUNDMAN-ENGBERG, B, JULIUSSON, G, STENKE, L, ELMHORN-ROSENBORG, A, MÖLLGARD, L, LEHMAN, S

“…The aim of the present study was to evaluate the effect of the cyclosporine derivative valspodar (PSC 833; Amdray, Novartis Pharma, Basel, Switzerland) on the…”
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High complete remission rate from 2-chloro-2'-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count by Juliusson, G, Liliemark, J

“…This study attempted to characterize the response of previously treated patients with B-cell chronic lymphocytic leukemia (CLL) to the purine analog…”
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Long-term survival following cladribine (2-chlorodeoxyadenosine) therapy in previously treated patients with chronic lymphocytic leukemia by Juliusson, G., Liliemark, J.

“…Purpose: To assess long-term survival following cladribine salvage treatment for previously treated patients with chronic lymphocytic leukemia. Patients and…”
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Granulocyte‐macrophage colony‐stimulating factor to increase efficacy of mitoxantrone, etoposide and cytarabine in previously untreated elderly patients with acute myeloid leukaemia: a Swedish multicentre randomized trial by Löfgren, C., Paul, C., Åström, M., Hast, R., Hedenius, M., Lerner, R., Liliemark, J., Nilsson, I., Rödjer, S., Simonsson, B., Stockelberg, D., Tidefelt, U., Björkholm, M.

“…Summary A total of 110 patients, aged 64 years or over, with de novo acute myeloid leukaemia (AML) and white blood cell counts <50 × 109/l were treated with 3…”
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Oral cladribine as primary therapy for patients with B-cell chronic lymphocytic leukemia by Juliusson, G, Christiansen, I, Hansen, M M, Johnson, S, Kimby, E, Elmhorn-Rosenborg, A, Liliemark, J

“…Purine analogs have wide potential indications in the treatment of hematologic malignancies, but intravenous administration has been required. We previously…”
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On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration by Liliemark, J, Albertioni, F, Hassan, M, Juliusson, G

“…The antimetabolite 2-chloro-2'-deoxyadenosine (CdA) is a promising alternative to alkylating agents for the treatment of lymphoproliferative disorders. Its…”
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Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors by Csoka, K, Liliemark, J, Larsson, R, Nygren, P

“…Gemcitabine (2'-deoxy-2',2'-difluorocytidine; dFdC) is a novel nucleoside analog that has shown clinical activity against solid tumors. The semiautomated…”
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Pharmacoeconomics behind next-generation oncology drug development by Zwierzina, H, Liliemark, J, deBock, A

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Cellular pharmacokinetics of 2-chloro-2'-deoxyadenosine nucleotides: comparison of intermittent and continuous intravenous infusion and subcutaneous and oral administration in leukemia patients by LILIEMARK, J, JULIUSSON, G

“…2-Chloro-2'-deoxyadenosine (CdA) is a new purine nucleoside analogue with major activity in lymphoproliferative diseases. Its intracellular nucleotides, in…”
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Pharmacokinetics of cladribine in plasma and its 5'-monophosphate and 5'-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia by ALBERTIONI, F, LINDEMALM, S, REICHELOVA, V, PETTERSSON, B, ERIKSSON, S, JULIUSSON, G, LILIEMARK, J

“…The pharmacokinetic parameters of cladribine (CdA) in patient plasma and its intracellular nucleotides CdA 5'-monophosphate (CdAMP) and CdA 5'-triphosphate…”
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Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues by Spasokoukotskaja, T., Arnér, E.S.J., Brosjö, O., Gunvén, P., Juliusson, G., Liliemark, J., Eriksson, S.

“…Deoxycytidine kinase (dCK) activates several clinically important drugs, including the recently developed antileukaemic compound 2-chlorodeoxyadenosine (CdA)…”
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Saturation of 1-β-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-β-D-arabinofuranosylcytosine therapy by PLUNKETT, W, LILIEMARK, J. O, ADAMS, T. M, NOWAK, B, ESTEY, E, KANTARJIAN, H, KEATING, M. J

“…Twenty-seven patients with refractory leukemia were treated with 1-beta-D-arabinofuranosylcytosine (ara-C), 0.3 to 3.0 g/m2 as i.v. infusions over 1, 2, 4, or…”
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Etoposide‐induced DNA strand breaks in relation to p‐glycoprotein and topoisomerase II protein expression in leukaemic cells from patients with AML and CLL by Zhou, R., Vitols, S., Gruber, A., Liliemark, J., Wang, Y., Liliemark, E.

“…Elevated expression of the membrane transporter p‐glycoprotein (pgp) and impaired expression of the nuclear enzyme topoisomerase II (topo II) are well‐known…”
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Gain of chromosome 7 marks the progression from indolent to aggressive follicle centre lymphoma and is a common finding in patients with diffuse large B‐cell lymphoma: a study by FISH by BERNELL, P, JACOBSSON, B, LILIEMARK, J, HJALMAR, V, ARVIDSSON, I, HAST, R

“…Gain of chromosome 7 represents one of the most frequent cytogenetic findings in B‐cell lymphomas with a follicular growth pattern. We used fluorescence in…”
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Dose escalation of high-dose cyclophosphamide and etoposide with high-dose doxorubicin (CDE) and filgrastim for poor-risk non-Hodgkin's lymphoma by Juliusson, G., Liliemark, J.

“…Purpose: To identify the highest possible dose of cyclophosphamide (C) and etoposide (E) to be given with high-dose doxorubicin (D) and filgrastim (G-CSF) but…”
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Long-term follow-up of patients ≥ 60 yr old with acute myeloid leukaemia treated with intensive chemotherapy: A randomised trial of aclarubicin vs. daunorubicin in combination with cytosine arabinoside and thioguanine by ÖBERG, G, KILLANDER, A, PAUL, C, SIMONSSON, B, STALFELT, A.-M, STENKE, L, TIDEFELT, U, UDEN, A.-M, BJÖRKHOLM, M, BJÖREMAN, M, GAHRTON, G, GRIMFORS, G, GRUBER, A, HAST, R, LERNER, R, LILIEMARK, J, MATTSON, S

“…It is still controversial how to treat elderly patients with acute myeloid leukaemia (AML), and results have been poor with most regimens. We report the…”
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Oral etoposide in patients with hematological malignancies: a clinical and pharmacokinetic study by Osby, E, Liliemark, E, Björkholm, M, Liliemark, J

“…Tumor responses after daily oral administration of low-dose etoposide have been demonstrated in both hematological and solid tumors. The aim of the present…”
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Long-term follow-up of patients ≥60 yr old with acute myeloid leukaemia treated with intensive chemotherapy by Öberg, G., Killander, A., Björeman, M., Gahrton, G., Grimfors, G., Gruber, A., Hast, R., Lerner, R., Liliemark, J., Mattson, S., Paul, C., Simonsson, B., Stalfelt, A.-M., Stenke, L., Tidefelt, U., Udén, A.-M., Björkholm, M.

“…:  It is still controversial how to treat elderly patients with acute myeloid leukaemia (AML), and results have been poor with most regimens. We report the…”
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