Search Results - "Liles, T."

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension by Budas, Grant R, Boehm, Mario, Kojonazarov, Baktybek, Viswanathan, Gayathri, Tian, Xia, Veeroju, Swathi, Novoyatleva, Tatyana, Grimminger, Friedrich, Hinojosa-Kirschenbaum, Ford, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Liles, John T, Schermuly, Ralph T

“…Progression of pulmonary arterial hypertension (PAH) is associated with pathological remodeling of the pulmonary vasculature and the right ventricle (RV)…”
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Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury by Xie, Yuchao, Ramachandran, Anup, Breckenridge, David G., Liles, John T., Lebofsky, Margitta, Farhood, Anwar, Jaeschke, Hartmut

“…Metabolic activation and oxidant stress are key events in the pathophysiology of acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative…”
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ASK1 contributes to fibrosis and dysfunction in models of kidney disease by Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, Ford, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G

“…Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis signal-regulating kinase 1 (ASK1) is a widely expressed…”
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ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice by Tesch, Greg H, Ma, Frank Y, Han, Yingjie, Liles, John T, Breckenridge, David G, Nikolic-Paterson, David J

“…p38 mitogen-activated protein kinase (MAPK) signaling promotes diabetic kidney injury. Apoptosis signal-regulating kinase (ASK)1 is one of the upstream kinases…”
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Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis by Leong, Khai Gene, Ozols, Elyce, Kanellis, John, Badal, Shawn S, Liles, John T, Nikolic-Paterson, David J, Ma, Frank Y

“…Cyclophilins have important homeostatic roles, but following tissue injury, cyclophilin A (CypA) can promote leukocyte recruitment and inflammation, while CypD…”
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The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model by Schwabl, Philipp, Hambruch, Eva, Budas, Grant R, Supper, Paul, Burnet, Michael, Liles, John T, Birkel, Manfred, Brusilovskaya, Ksenia, Königshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J, Trauner, Michael, Breckenridge, David G, Kremoser, Claus, Reiberger, Thomas

“…The farnesoid X receptor (FXR) influences hepatic metabolism, inflammation and liver fibrosis as key components of non-alcoholic steatohepatitis (NASH). We…”
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AT2R Autoantibodies Block Angiotensin II and AT1R Autoantibody-Induced Vasoconstriction by Liles, Campbell, Li, Hongliang, Veitla, Vineet, Liles, Jonathan T, Murphy, Taylor A, Cunningham, Madeleine W, Yu, Xichun, Kem, David C

“…Activating autoantibodies to the angiotensin type 1 receptor (AT1R) are associated with hypertensive disorders. The angiotensin type 2 receptor (AT2R) is known…”
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Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis by Fuchs, Claudia D., Sroda, Natalie, Scharnagl, Hubert, Gupta, Ruchi, Minto, Wesley, Stojakovic, Tatjana, Liles, John T., Budas, Grant, Hollenback, David, Trauner, Michael

“…The nuclear receptor farnesoid X receptor (FXR) is a key regulator of hepatic bile acid (BA) and lipid metabolism, inflammation and fibrosis. Here, we aimed to…”
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Relationship between anxiety and cognitive performance in an elderly population with a cognitive complaint by Delphin-Combe, F., Bathsavanis, A., Rouch, I., Liles, T., Vannier-Nitenberg, C., Fantino, B., Dauphinot, V., Krolak-Salmon, P.

“…Background and purpose Almost half of elderly patients being consulted in memory clinics present anxiety disorders, either with or without an associated…”
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IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma by Maloney, D G, Grillo-López, A J, Bodkin, D J, White, C A, Liles, T M, Royston, I, Varns, C, Rosenberg, J, Levy, R

“…To evaluate the safety, pharmacokinetics, and biologic effect of multiple doses of the chimeric anti-CD20 monoclonal antibody (mAb) IDEC-C2B8 in patients with…”
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IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma by MALONEY, D. G, GRILLO-LOPEZ, A. J, WEY, K, ROYSTON, I, DAVIS, T, LEVY, R, WHITE, C. A, BODKIN, D, SCHILDER, R. J, NEIDHART, J. A, JANAKIRAMAN, N, FOON, K. A, LILES, T.-M, DALLAIRE, B. K

“…IDEC-C2B8 is a chimeric monoclonal antibody (MoAb) directed against the B-cell-specific antigen CD20 expressed on non-Hodgkin's lymphomas (NHL). The MoAb…”
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Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma : Long-term results of a clinical trial by HSU, F. J, CASPAR, C. B, CZERWINSKI, D, KWAK, L. W, LILES, T. M, SYRENGELAS, A, TAIDI-LASKOWSKI, B, LEVY, R

“…The surface Ig on each B-cell lymphoma has unique portions (idiotypes), which can be recognized by the immune system. In this study, we immunized patients…”
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Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma by Maloney, D G, Liles, T M, Czerwinski, D K, Waldichuk, C, Rosenberg, J, Grillo-Lopez, A, Levy, R

“…The B-cell antigen CD20 is expressed on normal B cells and by nearly all B-cell lymphomas. This nonmodulating antigen provides an excellent target for…”
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Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma by KNOX, S. J, GORIS, M. L, FOWLER, S, DEB, N, BECKER, M, MARQUEZ, C, LEVY, R, TRISLER, K, NEGRIN, R, DAVIS, T, LILES, T.-M, GRILLO-LOPEZ, A, CHINN, P, VARNS, C, SHOU-CHENG NING

“…A Phase I/II dose escalation study of 90Y-murine anti-CD20 monoclonal antibody (mAb) in patients with recurrent B-cell lymphoma was performed. The primary…”
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Pressor responses to ephedrine are mediated by a direct mechanism in the rat by Liles, John T, Dabisch, Paul A, Hude, Keith E, Pradhan, Leena, Varner, Kurt J, Porter, Johnny R, Hicks, Alissa R, Corll, Conni, Baber, Syed R, Kadowitz, Philip J

“…The mechanism of the pressor response to ephedrine is controversial. In the present study. i.v. injections of ephedrine increased systemic and pulmonary…”
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Ranolazine reduces remodeling of the right ventricle and provoked arrhythmias in rats with pulmonary hypertension by Liles, John T, Hoyer, Kirsten, Oliver, Jason, Chi, Liguo, Dhalla, Arvinder K, Belardinelli, Luiz

“…Pulmonary arterial hypertension (PAH) is a progressive disease that often results in right ventricular (RV) failure and death. During disease progression,…”
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ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis by Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie

“…Activation of p38 mitogen‐activated protein kinase (MAPK) and c‐Jun amino terminal kinase (JNK) is prominent in human crescentic glomerulonephritis. p38 and…”
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Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells by Hsu, Frank J, Benike, Claudia, Fagnoni, Francesco, Liles, Tina Marie, Czerwinski, Debra, Taidi, Behnaz, Engleman, Edgar G, Levy, Ronald

“…In this pilot study, we investigated the ability of autologous dendritic cells pulsed ex vivo with tumor-specific idiotype protein to stimulate host antitumor…”
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Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors by Cazanave, Sophie C, Warren, Andrew D, Pacula, Maciej, Touti, Fayçal, Zagorska, Anna, Gural, Nil, Huang, Eric K, Sherman, Sarah, Cheema, Mehar, Ibarra, Sabrina, Bates, Jamie, Billin, Andrew N, Liles, John T, Budas, Grant R, Breckenridge, David G, Tiniakos, Dina, Ratziu, Vlad, Daly, Ann K, Govaere, Olivier, Anstee, Quentin M, Gelrud, Louis, Luther, Jay, Chung, Raymond T, Corey, Kathleen E, Winckler, Wendy, Bhatia, Sangeeta, Kwong, Gabriel A

“…Noninvasive detection of nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease, promises to improve patient screening,…”
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ASK 1 inhibitor treatment suppresses p38/ JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis by Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie

“…Activation of p38 mitogen‐activated protein kinase ( MAPK ) and c‐Jun amino terminal kinase ( JNK ) is prominent in human crescentic glomerulonephritis. p38…”
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