Search Results - "Likhoshvai, Vitaly A."
-
1
Limit cycles in models of circular gene networks regulated by negative feedback loops
Published in BMC bioinformatics (14-09-2020)“…The regulatory feedback loops that present in structural and functional organization of molecular-genetic systems and the phenomenon of the regulatory signal…”
Get full text
Journal Article -
2
On the dynamical aspects of local translation at the activated synapse
Published in BMC bioinformatics (14-09-2020)“…The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, which regulates the efficiency of…”
Get full text
Journal Article -
3
Impact of Negative Feedbacks on De Novo Pyrimidines Biosynthesis in Escherichia coli
Published in International journal of molecular sciences (02-03-2023)“…Earlier studies aimed at investigating the metabolism of endogenous nucleoside triphosphates in synchronous cultures of cells revealed an auto-oscillatory mode…”
Get full text
Journal Article -
4
Evolution and extinction can occur rapidly: a modeling approach
Published in PeerJ (San Francisco, CA) (13-04-2021)“…Fossil record of Earth describing the last 500 million years is characterized by evolution discontinuity as well as recurring global extinctions of some…”
Get full text
Journal Article -
5
On the control mechanisms of the nitrite level in Escherichia coli cells: the mathematical model
Published in BMC microbiology (27-01-2016)“…Due to a high toxicity of nitrite and its metabolites, it is of high interest to study mechanisms underlying the low NO2 level maintenance in the cell. During…”
Get full text
Journal Article -
6
A plausible mechanism for auxin patterning along the developing root
Published in BMC systems biology (21-07-2010)“…In plant roots, auxin is critical for patterning and morphogenesis. It regulates cell elongation and division, the development and maintenance of root apical…”
Get full text
Journal Article -
7
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants
Published in PloS one (18-03-2014)“…As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real…”
Get full text
Journal Article -
8
Mathematical modeling of auxin transport in protoxylem and protophloem of Arabidopsis thaliana root tips
Published in Journal of bioinformatics and computational biology (01-02-2013)“…Phytohormone auxin is the main regulator of plant growth and development. Nonuniform auxin distribution in plant tissue sets positional information, which…”
Get more information
Journal Article -
9
Chaos and Hyperchaos in a Model of Ribosome Autocatalytic Synthesis
Published in Scientific reports (12-12-2016)“…Any vital activities of the cell are based on the ribosomes, which not only provide the basic machinery for the synthesis of all proteins necessary for cell…”
Get full text
Journal Article -
10
Chaos and hyperchaos in simple gene network with negative feedback and time delays
Published in Journal of bioinformatics and computational biology (01-04-2017)“…Today there are examples that prove the existence of chaotic dynamics at all levels of organization of living systems, except intracellular, although such a…”
Get more information
Journal Article -
11
Alternative splicing can lead to chaos
Published in Journal of bioinformatics and computational biology (01-02-2015)“…Alternative splicing is a widespread phenomenon in higher eukaryotes, where it serves as a mechanism to increase the functional diversity of proteins. This…”
Get more information
Journal Article -
12
Mathematical modeling of bacterial cell cycle: the problem of coordinating genome replication with cell growth
Published in Journal of bioinformatics and computational biology (01-06-2014)“…In this paper, we perform an analysis of bacterial cell-cycle models implementing different strategies to coordinately regulate genome replication and cell…”
Get more information
Journal Article -
13
On the chaos in gene networks
Published in Journal of bioinformatics and computational biology (01-02-2013)“…The methods for constructing "chaotic" nonlinear systems of differential equations modeling gene networks of arbitrary structure and dimensionality with…”
Get more information
Journal Article -
14
How multiple auxin responsive elements may interact in plant promoters: a reverse problem solution
Published in Journal of bioinformatics and computational biology (01-02-2013)“…Plant hormone auxin is a key regulator of growth and development. Auxin affects gene expression through ARF transcription factors, which bind specifically…”
Get more information
Journal Article -
15
Mathematical model for suppression of subgenomic hepatitis C virus RNA replication in cell culture
Published in Journal of bioinformatics and computational biology (01-04-2007)“…A mathematical model for suppression of the hepatitis C virus RNA replicon replication in Huh-7 cell culture in the presence of potential drugs was built…”
Get more information
Journal Article -
16
Impact of Negative Feedbacks on De Novo Pyrimidines Biosynthesis in IEscherichia coli/I
Published in International journal of molecular sciences (01-03-2023)“…Earlier studies aimed at investigating the metabolism of endogenous nucleoside triphosphates in synchronous cultures of E. coli cells revealed an…”
Get full text
Journal Article -
17
A cellular automaton to model the development of primary shoot meristems of Arabidopsis thaliana
Published in Journal of bioinformatics and computational biology (01-04-2007)“…Development of organisms is a very complex process in which a lot of gene networks of different cell types are integrated. Development of a cellular automaton…”
Get more information
Journal Article -
18
GeneNet Database: Description and Modeling of Gene Networks
Published in In silico biology (2002)“…Almost all cellular processes in an organism are controlled by gene networks. Here we report on the analysis of gene networks functioning using two associated…”
Get full text
Journal Article -
19
A computer system for analysis and integrated description of regulation of the molecular-genetic system of interferon induction and action
Published in Bioinformatics (01-04-1995)“…A new theoretical approach to elaboration of an information-analytical integrated knowledge base containing data on regulation and function of biological…”
Get full text
Journal Article