Search Results - "Liher Prieto"

Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists by Reyes, Efraim, Prieto, Liher, Milelli, Andrea

“…Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the…”
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Strain-release amination by Gianatassio, Ryan, Lopchuk, Justin M., Wang, Jie, Pan, Chung-Mao, Malins, Lara R., Prieto, Liher, Brandt, Thomas A., Collins, Michael R., Gallego, Gary M., Sach, Neal W., Spangler, Jillian E., Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S.

“…To optimize drug candidates, modern medicinal chemists are increasingly turning to an unconventional structural motif: small, strained ring systems. However,…”
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Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity by Lopchuk, Justin M, Fjelbye, Kasper, Kawamata, Yu, Malins, Lara R, Pan, Chung-Mao, Gianatassio, Ryan, Wang, Jie, Prieto, Liher, Bradow, James, Brandt, Thomas A, Collins, Michael R, Elleraas, Jeff, Ewanicki, Jason, Farrell, William, Fadeyi, Olugbeminiyi O, Gallego, Gary M, Mousseau, James J, Oliver, Robert, Sach, Neal W, Smith, Jason K, Spangler, Jillian E, Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S

“…Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning…”
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Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen‐Bonding/Ion‐Pairing Interactions by Villar, Laura, Uria, Uxue, Martínez, Jose I., Prieto, Liher, Reyes, Efraim, Carrillo, Luisa, Vicario, Jose L.

“…BINOL‐based N‐trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, the latter being…”
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Asymmetric Dual Enamine Catalysis/Hydrogen Bonding Activation by Efraím Reyes, Liher Prieto, Uxue Uria, Luisa Carrillo, Jose L. Vicario

“…Asymmetric enamine base activation of carbonyl compounds is a well-known and widely used strategy for providing functionalization of organic compounds in an…”
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Organocatalytic activation of cyclopropanes in asymmetric synthesis by Reyes, Efraím, Uria, Uxue, Prieto, Liher, Carrillo, Luisa, Vicario, Jose L.

“…Cyclopropanes are strained carbocycles that can undergo ring opening reactions in which one of the C–C bond present in the cycle is broken following a radical…”
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Favoring Trienamine Activation through Unconjugated Dienals: Organocatalytic Enantioselective Remote Functionalization of Alkenes by Prieto, Liher, Talavera, Garazi, Uria, Uxue, Reyes, Efraim, Vicario, Jose L., Carrillo, Luisa

“…Unconjugated 2,5‐dienals are more reactive substrates than the corresponding fully conjugated α,β,γ,δ‐unsaturated aldehydes towards organocatalytic activation…”
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Kinetic Resolution in Transannular Morita-Baylis-Hillman Reaction: An Approximation to the Synthesis of Sesquiterpenes from Guaiane Family by Raquel Mato, Rubén Manzano, Efraím Reyes, Liher Prieto, Uxue Uria, Luisa Carrillo, Jose L. Vicario

“…An approximation to the synthesis of several sesquiterpenes from the Guaiane family is described in which the core structure was obtained through a…”
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Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen‐Bonding/Ion‐Pairing Interactions by Villar, Laura, Uria, Uxue, Martínez, Jose I., Prieto, Liher, Reyes, Efraim, Carrillo, Luisa, Vicario, Jose L.

“…BINOL‐based N‐trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, the latter being…”
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Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes by Whyte, Andrew, Torelli, Alexa, Mirabi, Bijan, Prieto, Liher, Rodríguez, José F, Lautens, Mark

“…An asymmetric hydroarylative cyclization of enynes involving a C–H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an…”
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Asymmetric Synthesis of Boryl-Functionalized Cyclobutanols by Whyte, Andrew, Mirabi, Bijan, Torelli, Alexa, Prieto, Liher, Bajohr, Jonathan, Lautens, Mark

“…A diastereo- and enantioselective synthesis of boron-containing cyclobutanols is reported. We exploit an enantioselective borylcupration to generate a chiral…”
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Enantio‐ and Diastereodivergent Sequential Catalysis Featuring Two Transition‐Metal‐Catalyzed Asymmetric Reactions by Masson‐Makdissi, Jeanne, Prieto, Liher, Abel‐Snape, Xavier, Lautens, Mark

“…This study demonstrates the feasibility and inherent benefits of combining two distinct asymmetric transition‐metal‐catalyzed reactions in one pot. The…”
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Organic chemistry. Strain-release amination by Gianatassio, Ryan, Lopchuk, Justin M, Wang, Jie, Pan, Chung-Mao, Malins, Lara R, Prieto, Liher, Brandt, Thomas A, Collins, Michael R, Gallego, Gary M, Sach, Neal W, Spangler, Jillian E, Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S

“…To optimize drug candidates, modern medicinal chemists are increasingly turning to an unconventional structural motif: small, strained ring systems. However,…”
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Mechanistic Insights on the Enantioselective (4+3) Cycloaddition Between Oxyallylcations and Furans Catalyzed by BINOL‐Based Phosphoramides by Pedrón, Manuel, Villar, Laura, Uria, Uxue, Prieto, Liher, Tejero, Tomas, Merino, Pedro, Vicario, Jose L.

“…The mechanism of the enantioselective (4+3) cycloaddition between furan derivatives and oxyallylcations, which are generated from the corresponding oxiranes…”
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Transannular Enantioselective (3 + 2) Cycloaddition of Cycloalkenone Hydrazones under Brønsted Acid Catalysis by Sendra, Jana, Reyes, Efraim, Prieto, Liher, Fernández, Elena, Vicario, Jose L

“…Hydrazones derived from cycloalkenones undergo an enantioselective transannular formal (3 + 2) cycloaddition catalyzed by a chiral phosphoric acid. The…”
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Brønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3‑Substituted Indoles with Donor–Acceptor Cyclopropanes by Ortega, Alesandere, Uria, Uxue, Tejero, Tomás, Prieto, Liher, Reyes, Efraim, Merino, Pedro, Vicario, Jose L.

“…Acylcyclopropanes are employed as useful donor–acceptor cyclopropanes that undergo formal (4 + 2) cyclocondensation with N-unprotected 3-substituted indoles in…”
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γ-Substituted Allenic Amides in the Phosphine-Catalyzed Enantioselective Higher Order Cycloaddition with Azaheptafulvenes by Manzano, Rubén, Romaniega, Aketza, Prieto, Liher, Díaz, Estíbaliz, Reyes, Efraim, Uria, Uxue, Carrillo, Luisa, Vicario, Jose L

“…Racemic γ-substituted allenes undergo enantioselective higher order [8 + 2]-cycloaddition with azaheptafulvenes using a chiral amino acid derived…”
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Rhodium-Catalyzed Tandem Isomerization–Allylation: From Diallyl Carbonates to α‑Quaternary Aldehydes by Masson-Makdissi, Jeanne, Jang, Young Jin, Prieto, Liher, Taylor, Mark S, Lautens, Mark

“…We report a Rh-catalyzed tandem isomerization–allylation sequence for the generation of α-quaternary aldehydes, starting from unsymmetrical diallyl carbonates…”
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Cover Feature: Brønsted Acid versus Phase‐Transfer Catalysis in the Enantioselective Transannular Aminohalogenation of Enesultams (Chem. Eur. J. 62/2022) by Luis‐Barrera, Javier, Rodriguez, Sandra, Uria, Uxue, Reyes, Efraim, Prieto, Liher, Carrillo, Luisa, Pedrón, Manuel, Tejero, Tomás, Merino, Pedro, Vicario, Jose L.

“…Alice points out the preference of one conformational enantiomer by “crossing the mirror” thanks to the catalyst formed from the phosphoric acid and bromine…”
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Catalytic Generation of Donor‐Acceptor Cyclopropanes under N‐Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles by Prieto, Liher, Sánchez‐Díez, Eduardo, Uria, Uxue, Reyes, Efraím, Carrillo, Luisa, Vicario, Jose L.

“…Formylcyclopropanes undergo activation in the presence of an N‐heterocyclic carbene catalyst generating a donor‐acceptor cyclopropane intermediate with the…”
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