Search Results - "Lih-Yuan Lin"

Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics by Phan, Trinh T. T., Lin, Yu-Chun, Chou, Yu-Ting, Wu, Chien-Wei, Lin, Lih-Yuan

“…Tumor suppressor p53 plays a central role in preventing tumorigenesis. Here, we unravel how p53 modulates mitochondrial dynamics to restrain the metastatic…”
Get full text

The conserved basic residues and the charged amino acid residues at the α-helix of the zinc finger motif regulate the nuclear transport activity of triple C2H2 zinc finger proteins by Lin, Chih-Ying, Lin, Lih-Yuan

“…Zinc finger (ZF) motifs on proteins are frequently recognized as a structure for DNA binding. Accumulated reports indicate that ZF motifs contain nuclear…”
Get full text

A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes by Yeh, Yen-Nan, Hsin, Kun-Yi, Zimmer, Andreas, Lin, Lih-Yuan, Hung, Ming-Shiu

“…Leptin is an adipokine predominantly secreted by adipocytes and has many physiological roles, including in energy homeostasis. We identified that AM630, a…”
Get full text

Action mechanism of snake venom l-amino acid oxidase and its double-edged sword effect on cancer treatment: Role of pannexin 1-mediated interleukin-6 expression by Truong, Nam V., Phan, Trinh T.T., Hsu, Tzu-Sheng, Phu Duc, Phan, Lin, Lih-Yuan, Wu, Wen-Guey

“…Snake venom l-amino acid oxidases (svLAAOs) have been recognized as promising candidates for anticancer therapeutics. However, multiple aspects of their…”
Get full text

A novel cell-penetrating peptide derived from human eosinophil cationic protein by Fang, Shun-lung, Fan, Tan-chi, Fu, Hua-Wen, Chen, Chien-Jung, Hwang, Chi-Shin, Hung, Ta-Jen, Lin, Lih-Yuan, Chang, Margaret Dah-Tsyr

“…Cell-penetrating peptides (CPPs) are short peptides which can carry various types of molecules into cells; however, although most CPPs rapidly penetrate cells…”
Get full text

Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability by Tsai, Jia-Shiuan, Chao, Cheng-Han, Lin, Lih-Yuan

“…Cadmium is a known environmental carcinogen. Exposure of Cd leads to the activation of several proto-oncogenes in cells. We investigated here the mechanism of…”
Get full text

Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress by Phan, Trinh T. T., Truong, Nam V., Wu, Wen-Guey, Su, Yi-Chun, Hsu, Tzu-Sheng, Lin, Lih-Yuan

“…The tumor suppressor p53 primarily functions as a mediator of DNA damage-induced cell death, thereby contributing to the efficacy of genotoxic anticancer…”
Get full text

Nanoscaled biphasic calcium phosphate modulates osteogenesis and attenuates LPS-induced inflammation by Su, Yi-Chun, Phan, Trinh T T, Wang, Tzu-Wei, Chang, Shao-Hsuan, Lin, Feng-Huei, Hsu, Tzu-Sheng, Lin, Lih-Yuan

“…Micron-scale structure biphasic calcium phosphate (BCP) materials have demonstrated promising clinical outcomes in the field of bone tissue repair. However,…”
Get full text

Coordinative modulation of human zinc transporter 2 gene expression through active and suppressive regulators by Lu, Yu-Ju, Liu, Ya-Chuan, Lin, Meng-Chieh, Chen, Yi-Ting, Lin, Lih-Yuan

“…Zinc transporter 2 (ZnT2) is one of the cellular factors responsible for Zn homeostasis. Upon Zn overload, ZnT2 reduces cellular Zn by transporting it into…”
Get full text

A rapid and portable sensor based on protein-modified gold nanoparticle probes and lateral flow assay for naked eye detection of mercury ion by Chao, Cheng-Han, Wu, Chung-Shu, Huang, Chung-Chih, Liang, Jie-Chian, Wang, Hsiao-Ting, Tang, Pin-Ting, Lin, Lih-Yuan, Ko, Fu-Hsiang

“…[Display omitted] ► A rapid and portable sensor is fabricated. ► The sensor is based on protein-modified gold NPs probes and lateral flow assay. ► The low-cost…”
Get full text

Immobilization of metallothionein as a sensitive biosensor chip for the detection of metal ions by surface plasmon resonance by Wu, Ching-Mei, Lin, Lih-Yuan

“…A biosensor based on mammalian metallothionein (MT) for the detection of metal ions was developed and characterized. MT was immobilized onto a…”
Get full text

Comparison of organic and inorganic germanium compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer by Lin, Ming-Hsing, Hsu, Tzu-Sheng, Yang, Pei-Ming, Tsai, Meng-Yen, Perng, Tsong-Pyng, Lin, Lih-Yuan

“…Purpose: The aim of this work is to compare the radiosensitizing effect between organic and inorganic germanium compounds and to investigate whether…”
Get full text

Association of Asef and Cdc42 Expression to Tubular Injury in Diseased Human Kidney by Cheng, Hui-Teng, Juang, I Pu, Chen, Liang-Chin, Lin, Lih-Yuan, Chao, Cheng-Han

“…BackgroundCdc42 is a small guanosine-5′-triphosphatase of the Rho family and plays essential roles in the establishment of cellular polarity and tight…”
Get full text

Effect of cadmium on cell cycle progression in chinese hamster ovary cells by Yang, Pei-Ming, Chiu, Shu-Jun, Lin, Kwei-Ann, Lin, Lih-Yuan

“…Chinese hamster ovary K1 (CHO K1) cells are very sensitive to cadmium (Cd) toxicity. They were used to investigate the effect of Cd on cell cycle progression…”
Get full text

A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men by Sheu, Wayne Huey-Herng, Chen, Ying-Tsung, Lee, Wen-Jane, Wang, Chen-Wen, Lin, Lih-Yuan

“…Summary background Previous studies have suggested that serum ferritin is one of the components of the insulin resistance syndrome in Caucasians. Because serum…”
Get full text

On the expandability of free-space micromachined optical cross connects by Lih-Yuan Lin, Goldstein, E.L., Tkach, R.W.

“…Free-space micromachined optical-switching technology has emerged as a promising candidate for the large-scale optical cross connects that are needed in…”
Get full text

MEMS reconfigurable Vee antenna by Jung-Chih Chiao, Yiton Fu, Iao Mak Chio, DeLisio, M., Lih-Yuan Lin

“…A new architecture for microelectromechanical system (MEMS) reconfigurable Vee-antennas was presented. The planar antenna structure can be dynamically…”
Get full text

Arsenite-induced apoptosis can be attenuated via depletion of mTOR activity to restore autophagy by Wu, Chien-Wei, Lin, Pei-Jung, Tsai, Jia-Shiuan, Lin, Chih-Ying, Lin, Lih-Yuan

“…Arsenic and its compounds are toxic environmental pollutants and known carcinogens. We investigated here the mechanism of arsenite-induced damage in renal…”
Get full text

Alkaline induces metallothionein gene expression and potentiates cell proliferation in Chinese hamster ovary cells by Lin, Kuei-Ann, Chen, Je-Hsin, Lee, Dong-Fong, Lin, Lih-Yuan

“…Metallothionein (MT) gene expression is increased in cadmium resistant Chinese hamster ovary cells (CHO CdR) upon medium (regular or serum‐free) change during…”
Get full text

Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway by Ma, Yu-Hsin, Huang, Chin-Ping, Tsai, Jia-Shiuan, Shen, Mo-Yuan, Li, Yaw-Kuen, Lin, Lih-Yuan

“…► We examined the cytotoxicty of water-soluble germanium nanoparticles (wsGeNPs). ► The wsGeNP causes necrotic cell death and the damage can be rescued by…”
Get full text