Search Results - "Liguori, M. J."

Evaluation of miR-122 as a Serum Biomarker for Hepatotoxicity in Investigative Rat Toxicology Studies by Sharapova, T., Devanarayan, V., LeRoy, B., Liguori, M. J., Blomme, E., Buck, W., Maher, J.

“…MicroRNAs are short noncoding RNAs involved in regulation of gene expression. Certain microRNAs, including miR-122, seem to have ideal properties as biomarkers…”
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Reduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet by Sharapova, T., Talaty, N., Buck, W.R., Fossey, S., Liguori, M.J., Van Vleet, T.R.

“…Non-genotoxic carcinogens (NGCs) are known to cause perturbations in DNA methylation, which can be an early event leading to changes in gene expression and the…”
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Recombinant human interleukin-6 enhances the immunoglobulin secretion of a rabbit-rabbit hybridoma by Liguori, M J, Hoff-Velk, J A, Ostrow, D H

“…The generation of stable rabbit-rabbit hybridomas is now possible by the recent development of a rabbit fusion partner. The ability to generate rabbit…”
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Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals by Van Vleet, Terry R, Liguori, Michael J, Lynch, 3rd, James J, Rao, Mohan, Warder, Scott

“…Pharmaceutical discovery and development is a long and expensive process that, unfortunately, still results in a low success rate, with drug safety continuing…”
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GENE EXPRESSION IN HUMAN HEPATOCYTES IN SUSPENSION AFTER ISOLATION IS SIMILAR TO THE LIVER OF ORIGIN, IS NOT AFFECTED BY HEPATOCYTE COLD STORAGE AND CRYOPRESERVATION, BUT IS STRONGLY CHANGED AFTER HEPATOCYTE PLATING by RICHERT, Lysiane, LIGUORI, Michael J, ABADIE, Catherine, HEYD, Bruno, MANTION, Georges, HALKIC, Nermin, WARING, Jeffrey F

“…Isolated primary human hepatocytes are a well accepted system for evaluating pharmacological and toxicological effects in humans. However, questions remain…”
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Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils by Waring, Jeffrey F, Liguori, Michael J, Luyendyk, James P, Maddox, Jane F, Ganey, Patricia E, Stachlewitz, Robert F, North, Colin, Blomme, Eric A G, Roth, Robert A

“…Idiosyncratic drug toxicity refers to toxic reactions occurring in a small subset of patients and usually cannot be predicted during preclinical or early…”
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Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin by LIGUORI, Michael J, ANDERSON, Mark G, BUKOFZER, Stanley, MCKIM, Jan Es, PREGENZER, Jeffrey F, RETIEF, Jacques, SPEAR, Brian B, WARING, Jeffrey F

“…Idiosyncratic drug toxicity, defined as toxicity that is dose independent, host dependent, and usually cannot be predicted during preclinical or early phases…”
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Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions by Liguori, Michael J, Waring, Jeffrey F

“…Idiosyncratic drug reactions (IDRs) of a hepatic origin are a major health concern and a notoriously difficult challenge for the pharmaceutical industry. These…”
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Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals by Fricano, Meagan M, Ditewig, Amy C, Jung, Paul M, Liguori, Michael J, Blomme, Eric A G, Yang, Yi

“…Blood is an ideal tissue for the identification of novel genomic biomarkers for toxicity or efficacy. However, using blood for transcriptomic profiling…”
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