Search Results - "Ligtenberg, Antoon J. M."
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DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands
Published in European journal of immunology (01-03-2009)“…Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies…”
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The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria
Published in Blood (22-01-2009)“…The plasma membrane glycoprotein receptor CD163 is a member of the scavenger receptor cystein-rich (SRCR) superfamily class B that is highly expressed on…”
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Interindividual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults
Published in European journal of oral sciences (01-06-2015)“…A cross‐sectional observational study was conducted to evaluate interindividual biochemical variation in unstimulated whole saliva in a population of 268…”
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The scavenging capacity of DMBT1 is impaired by germline deletions
Published in Immunogenetics (New York) (01-06-2017)“…The Scavenger Receptor Cysteine-Rich (SRCR) proteins are an archaic group of proteins characterized by the presence of multiple SRCR domains. They are…”
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Deleted in malignant brain tumors-1 protein (DMBT1): a pattern recognition receptor with multiple binding sites
Published in International Journal of Molecular Sciences (01-12-2010)“…Deleted in Malignant Brain Tumors-1 protein (DMBT1), salivary agglutinin (DMBT1(SAG)), and lung glycoprotein-340 (DMBT1(GP340)) are three names for…”
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The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor
Published in Blood (15-06-2007)“…Erythropoiesis occurs in erythroblastic islands, where developing erythroblasts closely interact with macrophages. The adhesion molecules that govern…”
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The bacteria binding glycoprotein salivary agglutinin (SAG/gp340) activates complement via the lectin pathway
Published in Molecular immunology (01-10-2011)“…► Salivary agglutinin (SAG) activates complement via the lectin pathway. ► Periodate treatment of SAG abolishes MBL pathway complement activation. ► Complement…”
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The Effect of Exercise on Salivary Viscosity
Published in Diagnostics (Basel) (16-11-2016)“…A common experience after exercise is the presence of a thick and sticky saliva layer on the oral surfaces, which causes a feeling of a dry mouth. Since the…”
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Implications for Diagnostics in the Biochemistry and Physiology of Saliva
Published in Annals of the New York Academy of Sciences (01-03-2007)“…: Oral fluid mainly consists of a mixture of glandular salivas. In addition, it is contaminated by some crevicular fluid, containing serum constituents. The…”
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Bacteria Binding by DMBT1/SAG/gp-340 Is Confined to the VEVLXXXXW Motif in Its Scavenger Receptor Cysteine-rich Domains
Published in The Journal of biological chemistry (12-11-2004)“…The scavenger receptor cysteine-rich (SRCR) proteins form an archaic group of metazoan proteins characterized by the presence of SRCR domains. These proteins…”
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Diversity of SpaP in genetic and salivary agglutinin mediated adherence among Streptococcus mutans strains
Published in Scientific reports (27-12-2019)“…Streptococcus mutans SpaP mediates the binding of this cariogenic bacteria to tooth surfaces. It was reported that the SpaP of S. mutans clinical isolates…”
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Identification of salivary components that induce transition of hyphae to yeast in Candida albicans
Published in FEMS yeast research (01-11-2009)“…Candida albicans, the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphae and hyphae…”
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The effect of physical exercise on salivary secretion of MUC5B, amylase and lysozyme
Published in Archives of oral biology (01-11-2015)“…Highlights • Saliva secretion increases after 10 min exercise. • Secretion of total salivary protein, amylase and lysozyme increase after exercise. • MUC5B…”
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The effect of caffeine on working memory load-related brain activation in middle-aged males
Published in Neuropharmacology (01-01-2013)“…Caffeine is commonly consumed in an effort to enhance cognitive performance. However, little is known about the usefulness of caffeine with regard to memory…”
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Binding of salivary agglutinin to IgA
Published in Biochemical journal (01-10-2004)“…SAG (salivary agglutinin), which is identical to gp-340 (glycoprotein-340) from the lung, is encoded by DMBT1 (deleted in malignant brain tumours 1). It is a…”
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Polymorphonuclear neutrophil integrity and functionality are preserved when exposed to saliva
Published in Archives of oral biology (01-08-2018)“…•Determine phenotypic changes of neutrophils after contact with human saliva.•Neutrophil morphology and function is not affected in the presence of…”
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Complement activation by salivary agglutinin is secretor status dependent
Published in Biological chemistry (01-01-2015)“…After mucosal damage or gingival inflammation, complement proteins leak into the oral cavity and mix with salivary proteins such as salivary agglutinin…”
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Antimicrobial defense systems in saliva
Published in Monographs in oral science (01-01-2014)“…The oral cavity is one of the most heavily colonized parts of our body. The warm, nutrient-rich and moist environment promotes the growth of a diverse…”
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The Human Glycoprotein Salivary Agglutinin Inhibits the Interaction of DC-SIGN and Langerin with Oral Micro-Organisms
Published in Journal of innate immunity (01-01-2016)“…Salivary agglutinin (SAG), also known as gp340 or SALSA, is a glycoprotein encoded by the Deleted in Malignant Brain Tumours 1 gene and is abundantly present…”
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Saliva and wound healing
Published in Monographs in oral science (01-01-2014)“…Oral wounds heal faster and with less scar formation than skin wounds. One of the key factors involved is saliva, which promotes wound healing in several ways…”
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