Search Results - "Ligon, K.L."

Glioblastoma targeted therapy: updated approaches from recent biological insights by Touat, M., Idbaih, A., Sanson, M., Ligon, K.L.

“…Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults, representing a highly heterogeneous group of neoplasms that are…”
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Survival Outcomes in Genetic Subgroups of Glioblastoma: Implications for Trial Design by Tanguturi, S, Ramkissoon, S, Horvath, M.C, Reardon, D.A, Lindeman, N, Ligon, A.H, Trippa, L, Wen, P, Ligon, K.L, Alexander, B.M

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Chemoradiation-Related Lymphopenia Is Common Among Glioblastoma Patients and Is Associated With Worse Progression-Free and Overall Survival by Rahman, R, Catalano, P.J, Arvold, N.D, Aizer, A.A, Weiss, S.E, Pinnell, N, Horvath, M.C, Christianson, L, Reardon, D.A, Lee, E.Q, Nayak, L, Rinne, M, Dunn, I.F, Golby, A.J, Johnson, M.D, Claus, E.B, Ligon, K.L, Wen, P, Alexander, B.M

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Functional Profiling of a Glioblastoma (GBM) Patient-Derived Cell Line (PDCL) Panel Identifies Cell-Intrinsic Differential Radiation Response That Correlates With TP53 Mutations by Huynh, M.A, Maire, C.L, Abazeed, M, Adams, D, Pelton, K, Pinnell, N, Ramkissoon, S, Korideck, H, Van Hummelen, P, Thorner, A, Wen, P, Ligon, A.H, Schreiber, S, Meyerson, M, Ligon, K.L, Alexander, B.M

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Disconnect Between Recurrence-Free Survival and Overall Survival for Newly Diagnosed Glioblastoma Patients Receiving Adjuvant Bevacizumab by Arvold, N.D, Wen, P.Y, Reardon, D.A, Lee, E.Q, Pinnell, N.E, Christianson, L.W, Weiss, S.E, Dunn, I.F, Ligon, K.L, Alexander, B.M

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Hypofractionated (HRT) Versus Standard (SRT) Radiation Therapy With or Without Temozolomide (T) for Elderly Patients With Glioblastoma (GBM) by Tanguturi, S, Wen, P.Y, Reardon, D.A, Lee, E.Q, Nayak, L, Christianson, L.W, Horvath, M.C, Dunn, I.F, Golby, A.J, Johnson, M.D, Claus, E.B, Chiocca, E.A, Ligon, K.L, Alexander, B.M, Arvold, N.D

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Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma by Zheng, H, Ying, H, Yan, H, Kimmelman, A C, Hiller, D J, Chen, A-J, Perry, S R, Tonon, G, Chu, G C, Ding, Z, Stommel, J M, Dunn, K L, Wiedemeyer, R, You, M J, Brennan, C, Wang, Y A, Ligon, K L, Wong, W H, Chin, L, dePinho, R A

“…Glioblastoma (GBM) is a highly lethal primary brain cancer with hallmark features of diffuse invasion, intense apoptosis resistance and florid necrosis, robust…”
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Impact of Delay in Initiation of Radiation Therapy in Newly Diagnosed Glioblastoma Patients after Gross Total Resection by Tabrizi, S., Rahman, R., Cagney, D.N., Aizer, A.A., Tanguturi, S., Arvold, N.D., Reardon, D.A., Lee, E.Q., Nayak, L., Rinne, M., Ligon, K.L., Wen, P., Alexander, B.

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Identification of De Novo Pyrimidine Synthesis as a Targetable Vulnerability in a Novel IDH1 Mutant Engineered Astrocytoma Model by Shi, D.D., Wang, A.C., Gao, W., Khanal, J., Levitt, M.M., Jennings, R.B., Signoretti, S., Nguyen, Q.D., Endress, J.E., Xu, M., Gradl, S., Sutter, A., Jeffers, M., Janzer, A., Cahill, D.P., Abdullah, K.G., Ligon, K.L., Harris, I.S., Kaelin, W.G., McBrayer, S.K.

“…Despite high prevalence of IDH1-R132H mutations in grade II-III gliomas, effective therapies remain limited. We sought to identify tumor-specific…”
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MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma by Jaimes, C, Vajapeyam, S, Brown, D, Kao, P-C, Ma, C, Greenspan, L, Gupta, N, Goumnerova, L, Bandopahayay, P, Dubois, F, Greenwald, N F, Zack, T, Shapira, O, Beroukhim, R, Ligon, K L, Chi, S, Kieran, M W, Wright, K D, Poussaint, T Y

“…Recent advances in molecular techniques have characterized distinct subtypes of diffuse intrinsic pontine gliomas. Our aim was the identification of MR imaging…”
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Evaluation of Sex-Based Differences in Patient Characteristics, Tumor-Related Factors, and Clinical Outcomes in Patients With Newly Diagnosed IDH-Wildtype Glioblastoma Receiving Chemoradiation by Shi, D.D., Lim-Fat, M.J., Youssef, G.C., Whorral, S., Allen, M., Cagney, D.N., Tanguturi, S., Haas-Kogan, D.A., Aizer, A.A., McFaline-Figueroa, J.R., Chukwueke, U.N., Lee, E.Q., Reardon, D.A., Nayak, L., Bi, W.L., Beroukhim, R., Ligon, K.L., Alexander, B.M., Wen, P.Y., Rahman, R.

“…While glioblastoma (GBM) is known to have increased incidence in males, recent work has identified possible sex-specific molecular differences that could be…”
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Salvage Re-Irradiation for Recurrent High-Grade Glioma and Comparison to Bevacizumab Alone by Shi, D.D., Arvold, N.D., Aizer, A.A., Norden, A.D., Reardon, D.A., Lee, E.Q., Nayak, L., Dunn, I.F., Golby, A.J., Johnson, M.D., Claus, E.B., Chiocca, A., Ligon, K.L., Wen, P., Alexander, B.M.

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Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK by Katz, S G, Fisher, J K, Correll, M, Bronson, R T, Ligon, K L, Walensky, L D

“…The proapoptotic BCL-2 family proteins BAX and BAK serve as essential gatekeepers of the intrinsic apoptotic pathway and, when activated, transform into…”
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Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis by Cserjesi, P, Brown, D, Ligon, K L, Lyons, G E, Copeland, N G, Gilbert, D J, Jenkins, N A, Olson, E N

“…Members of the basic helix-loop-helix (bHLH) family of transcription factors have been shown to regulate growth and differentiation of numerous cell types…”
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