Search Results - "Ligibel, Mathieu"

Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound by Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…Non‐heme iron halogenases are synthetically valuable biocatalysts that are capable of halogenating unactivated sp3‐hybridized carbon centers with high stereo‐…”
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Identification and application of threonine aldolase for synthesis of valuable α-amino, β-hydroxy-building blocks by Ligibel, Mathieu, Moore, Charles, Bruccoleri, Robert, Snajdrova, Radka

“…Chiral β-hydroxy α-amino acid structural motifs are interesting and common synthons present in multiple APIs and drug candidates. To access these chiral…”
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Modulating Chemoselectivity in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase for the Oxidative Modification of a Nonproteinogenic Amino Acid by Meyer, Fabian, Frey, Raphael, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

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Machine-Directed Evolution of an Imine Reductase for Activity and Stereoselectivity by Ma, Eric J, Siirola, Elina, Moore, Charles, Kummer, Arkadij, Stoeckli, Markus, Faller, Michael, Bouquet, Caroline, Eggimann, Fabian, Ligibel, Mathieu, Huynh, Dan, Cutler, Geoffrey, Siegrist, Luca, Lewis, Richard A, Acker, Anne-Christine, Freund, Ernst, Koch, Elke, Vogel, Markus, Schlingensiepen, Holger, Oakeley, Edward J, Snajdrova, Radka

“…Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to synthesize or purify. Time-efficient processes are needed to develop…”
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Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5 by Voss, Moritz, Hüppi, Sean, Schaub, Daniela, Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…Enzymatic late‐stage diversification of small molecules has the potential to rapidly generate diversity in compound libraries dedicated to drug discovery. In…”
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Cover Picture: Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound (Angew. Chem. Int. Ed. 51/2019) by Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…Tailored aliphatic halogenases enable the derivatization of unactivated carbon centers in non‐native substrates with exquisite stereo‐ and regioselectivity. In…”
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Front Cover: Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5 (ChemCatChem 24/2022) by Voss, Moritz, Hüppi, Sean, Schaub, Daniela, Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…The Front Cover depicts the opportunity to selectively chlorinate distinct stereoisomers of a bioactive molecule through the choice between tailored…”
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Cladosporin Derivatives Obtained by Biotransformation Provide Guidance for the Focused Derivatization of this Antimalarial Lead Compound by Fredenhagen, Andreas, Schroer, Kirsten, Schröder, Harald, Hoepfner, Dominic, Ligibel, Mathieu, Porchet Zemp, Liliane, Radoch, Caroline, Freund, Ernst, Meishammer, Aldo

“…Cladosporin, a natural product known for decades, has recently been discovered to display potent and selective antiplasmodial activity by inhibition of…”
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Titelbild: Evolvierte aliphatische Halogenasen ermöglichen die regiokomplementäre C‐H‐Funktionalisierung einer hochwertigen Chemikalie (Angew. Chem. 51/2019) by Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…Maßgeschneiderte aliphatische Halogenasen ermöglichen die Derivatisierung nichtaktivierter Kohlenstoffzentren in nichtnativen Substraten mit hoher Stereo‐ und…”
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Evolvierte aliphatische Halogenasen ermöglichen die regiokomplementäre C‐H‐Funktionalisierung einer hochwertigen Chemikalie by Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca

“…Nicht‐Häm‐Eisen(II)‐Halogenasen sind wertvolle Biokatalysatoren für die stereo‐ und enantioselektive Halogenierung von nicht‐aktivierten sp3‐Kohlenstoffatomen…”
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