Search Results - "Lightbody, Elizabeth D"

Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer by Shakfa, Noor, Li, Deyang, Conseil, Gwenaelle, Lightbody, Elizabeth D, Wilson-Sanchez, Juliette, Hamade, Ali, Chenard, Stephen, Jawa, Natasha A., Laight, Brian J., Afriyie-Asante, Afrakoma, Tyryshkin, Kathrin, Koebel, Martin, Koti, Madhuri

“…BackgroundHigh-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy characterized by resistance to chemotherapy and high rates of…”
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Mass cytometry staining for human bone marrow clinical samples by Hallisey, Margaret, Dennis, Jenna, Abrecht, Charlotte, Pistofidis, Romanos Sklavenitis, Schork, Abigail N., Lightbody, Elizabeth D., Heilpern-Mallory, Daniel, Severgnini, Mariano, Ghobrial, Irene M., Hodi, F. Stephen, Baginska, Joanna

“…This protocol details a staining technique optimized for immunophenotyping of human bone marrow immune populations using mass cytometry. The protocol accounts…”
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Single-cell profiling of tumour evolution in multiple myeloma — opportunities for precision medicine by Dutta, Ankit K., Alberge, Jean-Baptiste, Sklavenitis-Pistofidis, Romanos, Lightbody, Elizabeth D., Getz, Gad, Ghobrial, Irene M.

“…Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by substantial intraclonal genetic heterogeneity. Although therapeutic…”
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Novel prognostic and predictive microRNA targets for triple‐negative breast cancer by Turashvili, Gulisa, Lightbody, Elizabeth D., Tyryshkin, Kathrin, SenGupta, Sandip K., Elliott, Bruce E., Madarnas, Yolanda, Ghaffari, Abdi, Day, Andrew, Nicol, Christopher J. B.

“…ABSTRACT Triple‐negative breast cancers (TNBCs) account for ~25% of all invasive carcinomas and represent a large subset of aggressive, high‐grade tumors…”
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Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma by Sklavenitis-Pistofidis, Romanos, Aranha, Michelle P., Redd, Robert A., Baginska, Joanna, Haradhvala, Nicholas J., Hallisey, Margaret, Dutta, Ankit K., Savell, Alexandra, Varmeh, Shohreh, Heilpern-Mallory, Daniel, Ujwary, Sylvia, Zavidij, Oksana, Aguet, Francois, Su, Nang K., Lightbody, Elizabeth D., Bustoros, Mark, Tahri, Sabrin, Mouhieddine, Tarek H., Wu, Ting, Flechon, Lea, Anand, Shankara, Rosenblatt, Jacalyn M., Zonder, Jeffrey, Vredenburgh, James J., Boruchov, Adam, Bhutani, Manisha, Usmani, Saad Z., Matous, Jeffrey, Yee, Andrew J., Jakubowiak, Andrzej, Laubach, Jacob, Manier, Salomon, Nadeem, Omar, Richardson, Paul, Badros, Ashraf Z., Mateos, Maria-Victoria, Trippa, Lorenzo, Getz, Gad, Ghobrial, Irene M.

“…Patients with smoldering multiple myeloma (SMM) are observed until progression, but early treatment may improve outcomes. We conducted a phase II trial of…”
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Attenuated response to SARS-CoV-2 vaccine in patients with asymptomatic precursor stages of multiple myeloma and Waldenstrom macroglobulinemia by Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Yue, Hong, Ferrari, Federico, Redd, Robert A., Lightbody, Elizabeth D., Russo, Massimiliano, Perry, Jacqueline, Horowitz, Erica, Justis, Anna V., Shayegh, Nader A., Savell, Alexandra, Prescott, Julia, Varmeh, Shohreh, Nowak, Radosław P., Hamilton, Mark, Auclair, Daniel, Marinac, Catherine R., Trippa, Lorenzo, Fischer, Eric S., Ghobrial, Irene M.

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An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications by Dasgupta, Asish, Chen, Kuang‐Hueih, Wu, Danchen, Hoskin, Victoria, Mewburn, Jeffrey, Lima, Patricia D. A., Parlow, Leah R. G., Hindmarch, Charles C. T., Martin, Ashley, Sykes, Edward A., Tayade, Chandrakant, Lightbody, Elizabeth D., Madarnas, Yolanda, SenGupta, Sandip K., Elliott, Bruce E., Nicol, Christopher J. B., Archer, Stephen L.

“…Excessive proliferation and apoptosis‐resistance are hallmarks of cancer. Increased dynamin‐related protein 1 (Drp1)‐mediated mitochondrial fission is one of…”
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MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology by Dutta, Ankit K, Alberge, Jean-Baptiste, Lightbody, Elizabeth D, Boehner, Cody J, Dunford, Andrew, Sklavenitis-Pistofidis, Romanos, Mouhieddine, Tarek H, Cowan, Annie N, Su, Nang Kham, Horowitz, Erica M, Barr, Hadley, Hevenor, Laura, Beckwith, Jenna B, Perry, Jacqueline, Cao, Amanda, Lin, Ziao, Kuhr, Frank K, Mastro, Richard G Del, Nadeem, Omar, Greipp, Patricia T, Stewart, Chip, Auclair, Daniel, Getz, Gad, Ghobrial, Irene M

“…Multiple myeloma (MM) develops from well-defined precursor stages; however, invasive bone marrow (BM) biopsy limits screening and monitoring strategies for…”
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Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study by El-Khoury, Habib, Lee, David J, Alberge, Jean-Baptiste, Redd, Robert, Cea-Curry, Christian J, Perry, Jacqueline, Barr, Hadley, Murphy, Ciara, Sakrikar, Dhananjay, Barnidge, David, Bustoros, Mark, Leblebjian, Houry, Cowan, Anna, Davis, Maya I, Amstutz, Julia, Boehner, Cody J, Lightbody, Elizabeth D, Sklavenitis-Pistofidis, Romanos, Perkins, Mark C, Harding, Stephen, Mo, Clifton C, Kapoor, Prashant, Mikhael, Joseph, Borrello, Ivan M, Fonseca, Rafael, Weiss, Scott T, Karlson, Elizabeth, Trippa, Lorenzo, Rebbeck, Timothy R, Getz, Gad, Marinac, Catherine R, Ghobrial, Irene M

“…Prevalence estimates for monoclonal gammopathy of undetermined significance (MGUS) are based on predominantly White study populations screened by serum protein…”
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Endothelial Cell-Targeted Deletion of PPAR γ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue by Akiyama, Taro E, Skelhorne-Gross, Graham E, Lightbody, Elizabeth D, Rubino, Rachel E, Shi, Jia Yue, McNamara, Lesley A, Sharma, Neelam, Zycband, Emanuel I, Gonzalez, Frank J, Liu, Haiying, Woods, John W, Chang, C H, Berger, Joel P, Nicol, Christopher J B

“…Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor (PPAR ) agonists that represent an effective class of insulin-sensitizing agents;…”
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Inhibition of MICA and MICB shedding enhances memory-like NK-cell–mediated cytotoxicity against multiple myeloma by Tahri, Sabrin, Piccinelli, Sara, Su, Nang Kham, Lampe, Luisa, Dong, Han, Vergara Cadavid, Juliana, Boiarsky, Rebecca, Papazian, Natalie, Lightbody, Elizabeth D., Cao, Amanda, Alberge, Jean-Baptiste, Ferrari de Andrade, Lucas, Rahmat, Mahshid, Shen, Yujia, Blanco Fernández, Laura, Zabaleta, Aintzane, Günther, Andreas, Getz, Gad, Sonneveld, Pieter, Cupedo, Tom, Wucherpfennig, Kai W., Ghobrial, Irene M., Romee, Rizwan

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In Situ Characterization of Chromatin Landscape in Progression of Smoldering Precursor Stage to Multiple Myeloma by Rahmat, Mahshid, Vinyard, Michael, Sklavenitis-Pistofidis, Romanos, Clement, Kendell, Lightbody, Elizabeth D., Boehner, Cody J., Hevenor, Laura, Perry, Jacqueline, Getz, Gad, Ghobrial, Irene

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Single-Cell RNA-Sequencing Identifies Immune Biomarkers of Progression in Patients with High-Risk Smoldering Multiple Myeloma Treated with Immunotherapy by Sklavenitis-Pistofidis, Romanos, Aranha, Michelle P., Haradhvala, Nicholas J., Varmeh, Shohreh, Heilpern-Mallory, Daniel, Wu, Ting, Su, Nang Kham, Lightbody, Elizabeth D., Aguet, François, Zavidij, Oksana, Tahri, Sabrin, Mouhieddine, Tarek H., Getz, Gad, Ghobrial, Irene

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Single-Cell RNA-Sequencing of 370 Bone Marrow and Peripheral Blood Immune Cell Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveal Significant Immune Dysregulation at the MGUS Stage, and Novel Interactions between Tumor and Immune Cells by Sklavenitis-Pistofidis, Romanos, Wu, Ting, Rahmat, Mahshid, Konishi, Yoshinobu, Lightbody, Elizabeth D., Timonian, Michael, Tsuji, Junko, Firer, Danielle T., Haradhvala, Nicholas J., Soekojo, Cinnie Yentia, Wang, Xiyue, Heilpern-Mallory, Daniel, Aguet, François, Getz, Gad, Ghobrial, Irene

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A High-Throughput Drug Screen Reveals a Novel Compound Class That Significantly Depletes IRF4 Expression in Multiple Myeloma by Lightbody, Elizabeth D., Reidy, Mairead, Agius, Michael P., El-Behaedi, Salma, Sklavenitis-Pistofidis, Romanos, Manier, Salomon, Ghobrial, Irene M.

“…Introduction Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal expansion of malignant plasma cells (PCs) within the…”
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Genome Sequencing to Discover Drivers of Clonal Expansion in Smoldering Multiple Myeloma by Alberge, Jean-Baptiste, Dutta, Ankit K., Lightbody, Elizabeth D., Poletti, Andrea, Wallin, Sofia, Dunford, Andrew, Coorens, Tim, Loinaz, Xavi, Boehner, Cody J., Su, Nang Kham, Hevenor, Laura, Towle, Katherine, Perry, Jacqueline, Kübler, Kirsten, Sklavenitis-Pistofidis, Romanos, Hess, Julian, Stewart, Chip, Getz, Gad, Ghobrial, Irene M.

“…Background Better prediction models are required to identify patients with high-risk smoldering multiple myeloma (SMM) who can benefit from early intervention…”
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Single-Cell RNA Sequencing Reveals Hypo-Responsiveness of T and NK Cells to Interferon Stimulation As an Immune Hallmark in Asymptomatic Waldenstrom's Macroglobulinemia by Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Mallory, Daniel L., Wu, Ting, Aranha, Michelle P., Tsuji, Junko, Haradhvala, Nicholas J, Lightbody, Elizabeth D., Towle, Katherine, Hevenor, Laura, Tsakmaklis, Nickolas, Wang, Xiyue, Canning, Alexa G, Liacos, Christine-Ivy, Kastritis, Efstathios, Dimopoulos, Meletios Athanasios, Treon, Steven P, Getz, Gady, Ghobrial, Irene M.

“…Introduction Waldenstrom macroglobulinemia (WM) is a rare, indolent non-Hodgkin lymphoplasmacytic lymphoma of the bone marrow (BM), characterized by monoclonal…”
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Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects by Aranha, Michelle P., Sklavenitis-Pistofidis, Romanos, Konishi, Yoshinobu, Wu, Ting, Yue, Hong, Lightbody, Elizabeth D., Rahmat, Mahshid, Timonian, Michael, Mallory, Daniel L., Agius, Michael P., Varmeh, Shohreh, Su, Nang Kham, Perry, Jacqueline, Horowitz, Erica M., Davis, Maya, Justis, Anna, Nowak, Radosław P., Hamilton, Mark, Auclair, Daniel, Marinac, Catherine R., Fischer, Eric, Getz, Gad, Ghobrial, Irene M.

“…Introduction Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) exhibit signs of immune dysregulation…”
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High-Throughput Plasma Proteomics to Define the Precursor Multiple Myeloma Proteome and Identify Candidate High-Risk Disease Biomarkers of Progression by Lightbody, Elizabeth D., Mani, D. R., Keshishian, Hasmik, El-Khoury, Habib, Dutta, Ankit K., Barr, Hadley, Udeshi, Namrata, Bertamini, Luca, Kham Su, Nang, Boehner, Cody J., Hevenor, Laura, Towle, Katherine, Fleming, Grace, Cea-Curry, Christian, Perry, Jacqueline, Horowitz, Erica M., Davis, Maya, Cowan, Annie, Marinac, Catherine R., Gillette, Michael, Carr, Steven A., Ghobrial, Irene M.

“…Introduction Multiple Myeloma (MM) develops from well-defined precursors Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple…”
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Single-Cell RNA Sequencing of Circulating Tumor Cells in Precursor Myeloma Patients Reveals Mechanisms of Disease Dissemination by Lightbody, Elizabeth D., Sklavenitis-Pistofidis, Romanos, Firer, Danielle T., Tsuji, Junko, Agius, Mike P., Dutta, Ankit K., Wu, Ting, Barr, Hadley, Kim, Sungjae, Coorens, Tim, Alberge, Jean-Baptiste, Aranha, Michelle P., Haradhvala, Nicholas J, Kham Su, Nang, Boehner, Cody J., Walsh, Kelly, Rahmat, Mahshid, Konishi, Yoshinobu, Hevenor, Laura, Towle, Katherine, Horowitz, Erica M., Perry, Jacqueline, Fleming, Grace, El-Khoury, Habib, Vinyard, Michael, Cowan, Annie, Auclair, Daniel, Ready, John E., Marinac, Catherine R., Getz, Gad, Ghobrial, Irene M.

“…Introduction Multiple Myeloma (MM) is preceded by the precursors Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma…”
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