Search Results - "Light, R. D"

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex by Bode, Wolfram, Fuentes-Prior, Pablo, Iwanaga, Yoriko, Huber, Robert, Pagila, Rene, Rumennik, Galina, Seto, Marian, Morser, John, Light, David R

“…The serine proteinase α-thrombin causes blood clotting through proteolytic cleavage of fibrinogen and protease-activated receptors and amplifies its own…”
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Preparation, Characterization, and the Crystal Structure of the Inhibitor ZK-807834 (CI-1031) Complexed with Factor Xa by Adler, Marc, Davey, David D, Phillips, Gary B, Kim, Sung-Hou, Jancarik, Jarmila, Rumennik, Galina, Light, David R, Whitlow, Marc

“…Factor Xa plays a critical role in the formation of blood clots. This serine protease catalyzes the conversion of prothrombin to thrombin, the first joint step…”
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An Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor Potentiates Tissue-Type Plasminogen Activator-Induced Thrombolysis in a Rabbit Jugular Vein Thrombolysis Model by Nagashima, Mariko, Werner, Matthias, Wang, Manping, Zhao, Lei, Light, David R, Pagila, Rene, Morser, John, Verhallen, Peter

“…When activated in vitro, thrombin-activatable fibrinolysis inhibitor (TAFI) slows clot lysis by cleaving the C-terminal lysine and arginine residues from…”
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Rubber elongation factor from Hevea brasiliensis. Identification, characterization, and role in rubber biosynthesis by DENNIS, M. S, LIGHT, D. R

“…The presence of a protein, rubber elongation factor (REF), which is tightly bound to serum-free rubber particles purified from Hevea brasiliensis latex, is…”
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FXa-Induced Responses in Vascular Wall Cells are PAR-Mediated and Inhibited by ZK-807834 by McLean, Kirk, Schirm, Sabine, Johns, Anthony, Morser, John, Light, David R

“…During thrombosis, vascular wall cells are exposed to clotting factors, including the procoagulant proteases thrombin and factor Xa (FXa), both known to induce…”
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The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain by Fuh, G, Mulkerrin, M G, Bass, S, McFarland, N, Brochier, M, Bourell, J H, Light, D R, Wells, J A

“…A gene fragment encoding the extracellular domain of the human growth hormone (hGH) receptor from liver was cloned into a plasmid under control of the…”
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Purification of a Prenyltransferase That Elongates cis-Polyisoprene Rubber from the Latex of Hevea brasiliensis by Light, D R, Dennis, M S

“…We have purified “rubber transferase” from latex of the commercial rubber tree Hevea brasiliensis and find that it is a dimer with a monomeric molecular mass…”
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Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834):  A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa by Phillips, Gary B, Buckman, Brad O, Davey, David D, Eagen, Keith A, Guilford, William J, Hinchman, Josephine, Ho, Elena, Koovakkat, Sunil, Liang, Amy, Light, David R, Mohan, Raju, Ng, Howard P, Post, Joseph M, Shaw, Kenneth J, Smith, Dave, Subramanyam, Babu, Sullivan, Mark E, Trinh, Lan, Vergona, Ron, Walters, Janette, White, Kathy, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M

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Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors by Guilford, William J, Shaw, Kenneth J, Dallas, Jerry L, Koovakkat, Sunil, Lee, Wheeseong, Liang, Amy, Light, David R, McCarrick, Margaret A, Whitlow, Marc, Ye, Bin, Morrissey, Michael M

“…Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation linking the intrinsic and extrinsic pathways to the final common…”
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Amino Acid Sequence of Rubber Elongation Factor Protein Associated with Rubber Particles in Hevea Latex by Dennis, M S, Henzel, W J, Bell, J, Kohr, W, Light, D R

“…The amino acid sequence of rubber elongation factor, a recently discovered protein tightly bound to rubber particles isolated from the commercial rubber tree…”
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Amino acid sequence similarity of Hev b 3 to two previously reported 27‐ and 23‐kDa latex proteins allergenic to spina bifida patients by Yeang, H.Y., Ward, M.A., Zamri, A.S.M., Dennis, M.S., Light, D.R.

“…Separate studies have reported spina bifida patients to be especially allergic t o proteins of 27 and 23 kDa found in the serum of centrifuged natural rubber…”
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Effect of vascular injury on inhibition of venous thrombosis with ZK‐807834, a direct inhibitor of factor Xa by Abendschein, D. R., Baum, P. K., Light, D. R., Morser, J.

“…Inhibition of factor Xa with the small molecule inhibitor ZK‐807834 (Mr 527 Da, Ki 0.11 nM) attenuates progression of thrombosis, but the ED50 is substantially…”
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Effects of ZK-807834, a Novel Inhibitor of Factor Xa, on Arterial and Venous Thrombosis in Rabbits by Abendschein, Dana R, Baum, Pamela K, Martin, Daniel J, Vergona, Ron, Post, Joseph, Rumennik, Galina, Sullivan, Mark E, Eisenberg, Paul R, Light, David R

“…Inhibition of factor Xa (FXa) may interrupt thrombus progression. This study compared the antithrombotic activity of a novel FXa inhibitor, ZK-807834 [MW, 527…”
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The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function by CLARKE, J. H, LIGHT, D. R, BLASKO, E, PARKINSON, J. F, NAGASHIMA, M, MCLEAN, K, VILANDER, L, ANDREWS, W. H, MORSER, J, GLASER, C. B

“…Thrombomodulin (TM) is a cofactor for activation of protein C by thrombin. We showed that 80-90% of this cofactor activity is lost by oxidation of Met388,…”
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Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin by Lin, J H, McLean, K, Morser, J, Young, T A, Wydro, R M, Andrews, W H, Light, D R

“…The two major glycoforms of full-length human thrombomodulin (TM), one with (TM(CS+)) and one without (TM(CS-)) chondroitin sulfate (CS) were analyzed on…”
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Rubber Elongation by Farnesyl Pyrophosphate Synthases Involves a Novel Switch in Enzyme Stereospecificity by Light, D R, Lazarus, R A, Dennis, M S

“…A prenyltransferase purified from the commercial rubber tree, Hevea brasiliensis, that elongates existing cis-polyisoprene rubber molecules also catalyzes the…”
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Conformations of Trypsin-Bound Amidine Inhibitors of Blood Coagulant Factor Xa by Double REDOR NMR and MD Simulations by McDowell, Lynda M, McCarrick, Margaret A, Studelska, Daniel R, Guilford, William J, Arnaiz, Damian, Dallas, Jerry L, Light, David R, Whitlow, Marc, Schaefer, Jacob

“…Double rotational-echo double resonance (double REDOR) has been used to investigate the bound conformations of 13C,15N,19F-labeled factor Xa inhibitors to…”
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Temperature measurements during initiation and growth of a black smoker chimney by Tivey, M. K, Olson, L. O, Miller, V. W, Light, R. D

“…The results of a 46-day experiment which monitored the wall and fluid temperatures of black smoker chimneys are presented…”
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Seaglider: a long-range autonomous underwater vehicle for oceanographic research by Eriksen, C.C., Osse, T.J., Light, R.D., Wen, T., Lehman, T.W., Sabin, P.L., Ballard, J.W., Chiodi, A.M.

“…Seagliders are small, reusable autonomous underwater vehicles designed to glide from the ocean surface to a programmed depth and back while measuring…”
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Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity by LIGHT, D. R, DENNIS, M. S, FORSYTHE, I. J, CHUNG-CHENG LIU, GREEN, D. W, KRATZER, D. A, PLAPP, B. V

“…The cDNA for the alpha-isoenzyme from rhesus monkey (Macaca mulatta) liver was cloned and expressed in yeast. The alpha-isoenzymes of human and monkey liver…”
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