Search Results - "Light, A."

Future clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia by Light, Gregory A., Swerdlow, Neal R.

“…Advances in psychiatric neuroscience have transformed our understanding of impaired and spared brain functions in psychotic illnesses. Despite substantial…”
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Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders by Light, Gregory A., Näätänen, Risto

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Sensorimotor gating deficits in schizophrenia: Advancing our understanding of the phenotype, its neural circuitry and genetic substrates by Swerdlow, Neal R., Light, Gregory A.

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Myalgic encephalomyelitis: International Consensus Criteria by Carruthers, B. M., van de Sande, M. I., De Meirleir, K. L., Klimas, N. G., Broderick, G., Mitchell, T., Staines, D., Powles, A. C. P., Speight, N., Vallings, R., Bateman, L., Baumgarten‐Austrheim, B., Bell, D. S., Carlo‐Stella, N., Chia, J., Darragh, A., Jo, D., Lewis, D., Light, A. R., Marshall‐Gradisbik, S., Mena, I., Mikovits, J. A., Miwa, K., Murovska, M., Pall, M. L., Stevens, S.

“…  Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles ACP, Speight N, Vallings R, Bateman L,…”
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Automatic sensory information processing abnormalities across the illness course of schizophrenia by Jahshan, C, Cadenhead, K S, Rissling, A J, Kirihara, K, Braff, D L, Light, G A

“…Deficits in automatic sensory discrimination, as indexed by a reduction in the mismatch negativity (MMN) and P3a event-related potential amplitudes, are well…”
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Realistic expectations of prepulse inhibition in translational models for schizophrenia research by Swerdlow, Neal R., Weber, Martin, Qu, Ying, Light, Gregory A., Braff, David L.

“…Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the startling effects of a subsequent intense abrupt stimulus. This…”
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Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia by Light, Gregory A, Swerdlow, Neal R, Rissling, Anthony J, Radant, Allen, Sugar, Catherine A, Sprock, Joyce, Pela, Marlena, Geyer, Mark A, Braff, David L

“…Endophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical…”
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Hierarchical Pathways from Sensory Processing to Cognitive, Clinical, and Functional Impairments in Schizophrenia by Koshiyama, Daisuke, Thomas, Michael L, Miyakoshi, Makoto, Joshi, Yash B, Molina, Juan L, Tanaka-Koshiyama, Kumiko, Sprock, Joyce, Braff, David L, Swerdlow, Neal R, Light, Gregory A

“…Abstract Cognitive impairment is a hallmark of schizophrenia and a robust predictor of functional outcomes. Impairments are found in all phases of the illness…”
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Hierarchical Organization of Gamma and Theta Oscillatory Dynamics in Schizophrenia by Kirihara, Kenji, Rissling, Anthony J, Swerdlow, Neal R, Braff, David L, Light, Gregory A

“…Background Schizophrenia patients have deficits across a broad range of important cognitive and clinical domains. Synchronization of oscillations in the gamma…”
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Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures by Turetsky, Bruce I., Calkins, Monica E., Light, Gregory A., Olincy, Ann, Radant, Allen D., Swerdlow, Neal R.

“…In an effort to reveal susceptibility genes, schizophrenia research has turned to the endophenotype strategy. Endophenotypes are characteristics that reflect…”
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Association analysis of 94 candidate genes and schizophrenia-related endophenotypes by Greenwood, Tiffany A, Light, Gregory A, Swerdlow, Neal R, Radant, Allen D, Braff, David L

“…While it is clear that schizophrenia is highly heritable, the genetic basis of this heritability is complex. Human genetic, brain imaging, and model organism…”
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Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia by Perez, Veronica B, Tarasenko, Melissa, Miyakoshi, Makoto, Pianka, Sean T, Makeig, Scott D, Braff, David L, Swerdlow, Neal R, Light, Gregory A

“…Computerized cognitive training is gaining empirical support for use in the treatment of schizophrenia (SZ). Although cognitive training is efficacious for SZ…”
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Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia by Thomas, Michael L, Green, Michael F, Hellemann, Gerhard, Sugar, Catherine A, Tarasenko, Melissa, Calkins, Monica E, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Seidman, Larry J, Shiluk, Alexandra L, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Swerdlow, Neal R, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L, Light, Gregory A

“…Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention…”
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The 5-choice continuous performance test: evidence for a translational test of vigilance for mice by Young, Jared W, Light, Gregory A, Marston, Hugh M, Sharp, Richard, Geyer, Mark A

“…Attentional dysfunction is related to functional disability in patients with neuropsychiatric disorders such as schizophrenia, bipolar disorder, and…”
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Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study by Greenwood, Tiffany A, Lazzeroni, Laura C, Maihofer, Adam X, Swerdlow, Neal R, Calkins, Monica E, Freedman, Robert, Green, Michael F, Light, Gregory A, Nievergelt, Caroline M, Nuechterlein, Keith H, Radant, Allen D, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Gur, Ruben C, Gur, Raquel E, Braff, David L

“…The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in…”
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Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome by Light, A. R., Bateman, L., Jo, D., Hughen, R. W., VanHaitsma, T. A., White, A. T., Light, K. C.

“…  Light AR, Bateman L, Jo D, Hughen RW, VanHaitsma TA, White AT, Light KC (University of Utah, Salt Lake City, UT, USA). Gene expression alterations at…”
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Gamma Band Oscillations Reveal Neural Network Cortical Coherence Dysfunction in Schizophrenia Patients by Light, Gregory A., Hsu, Jung Lung, Hsieh, Ming H., Meyer-Gomes, Katrin, Sprock, Joyce, Swerdlow, Neal R., Braff, David L.

“…Gamma band activity has been associated with many sensory and cognitive functions, and is important for cortico-cortical transmission and the integration of…”
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Unique contributions of sensory discrimination and gamma synchronization deficits to cognitive, clinical, and psychosocial functional impairments in schizophrenia by Koshiyama, Daisuke, Miyakoshi, Makoto, Thomas, Michael L., Joshi, Yash B., Molina, Juan L., Tanaka-Koshiyama, Kumiko, Sprock, Joyce, Braff, David L., Swerdlow, Neal R., Light, Gregory A.

“…Schizophrenia patients show widespread deficits in neurocognitive, clinical, and psychosocial functioning. Mismatch negativity (MMN) and gamma-band auditory…”
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Mismatch negativity reveals plasticity in cortical dynamics after 1-hour of auditory training exercises by Perez, Veronica B., Miyakoshi, Makoto, Makeig, Scott D., Light, Gregory A.

“…Impaired sensory processing contributes to deficits in cognitive and psychosocial functioning in individuals with schizophrenia (SZ). Mismatch Negativity…”
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Neural network dynamics underlying gamma synchronization deficits in schizophrenia by Koshiyama, Daisuke, Miyakoshi, Makoto, Joshi, Yash B., Molina, Juan L., Tanaka-Koshiyama, Kumiko, Joyce Sprock, Braff, David L., Swerdlow, Neal R., Light, Gregory A.

“…Gamma-band (40-Hz) activity is critical for cortico-cortical transmission and the integration of information across neural networks during sensory and…”
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