In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients

In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients

Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18%...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) Vol. 30; no. 6-8; pp. 338 - 341
Main Authors: Carnesecchi, Giulia, Lobello, Raffaele, Liggieri, Laura, Palmero, Candida, Pescetto, Luisa, Morelli, Patrizia, Castagnola, Elio, Bandettini, Roberto
Format: Journal Article
Language:English
Published: England Taylor & Francis 17-11-2018
Subjects:
Anti-Bacterial Agents - pharmacology
Ceftaroline
ceftobiprole
Cephalosporins - pharmacology
Child
Humans
methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests - methods
minimal inhibitory concentrations
paediatrics
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Vancomycin - pharmacology
paediatrics
minimal inhibitory concentrations
ceftobiprole
methicillin-resistant
Ceftaroline
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Summary:Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1.4% of strains was resistant to ceftobiprole, and none to ceftaroline. These results are worrisome, since show the presence of non-negligible proportions of MRSA strains with high MIC values for ceftaroline and ceftobiprole in a setting where both drugs were never used.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1120-009X
1973-9478
DOI:10.1080/1120009X.2018.1522473