Search Results - "Lifshitz, Lawrence"

Extraoral bitter taste receptors in health and disease by Lu, Ping, Zhang, Cheng-Hai, Lifshitz, Lawrence M, ZhuGe, Ronghua

“…Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane G protein-coupled receptors, which are the targets of >50% of drugs…”
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The cellular and molecular basis of bitter tastant-induced bronchodilation by Zhang, Cheng-Hai, Lifshitz, Lawrence M, Uy, Karl F, Ikebe, Mitsuo, Fogarty, Kevin E, ZhuGe, Ronghua

“…Bronchodilators are a standard medicine for treating airway obstructive diseases, and β2 adrenergic receptor agonists have been the most commonly used…”
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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells by Min, So Yun, Desai, Anand, Yang, Zinger, Sharma, Agastya, DeSouza, Tiffany, Genga, Ryan M. J., Kucukural, Alper, Lifshitz, Lawrence M., Nielsen, Søren, Scheele, Camilla, Maehr, René, Garber, Manuel, Corvera, Silvia

“…Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of cells required to mediate complex functions in multicellular organisms…”
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Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration by Qu, Mingzi, Lu, Ping, Lifshitz, Lawrence M., Moore Simas, Tiffany A., Delpapa, Ellen, ZhuGe, Ronghua

“…Uterine contractions during labor and preterm labor are influenced by a complex interplay of factors, including hormones and inflammatory mediators. This…”
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CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease by Tsagkaraki, Emmanouela, Nicoloro, Sarah M., DeSouza, Tiffany, Solivan-Rivera, Javier, Desai, Anand, Lifshitz, Lawrence M., Shen, Yuefei, Kelly, Mark, Guilherme, Adilson, Henriques, Felipe, Amrani, Nadia, Ibraheim, Raed, Rodriguez, Tomas C., Luk, Kevin, Maitland, Stacy, Friedline, Randall H., Tauer, Lauren, Hu, Xiaodi, Kim, Jason K., Wolfe, Scot A., Sontheimer, Erik J., Corvera, Silvia, Czech, Michael P.

“…Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular…”
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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis by Henriques, Felipe, Bedard, Alexander H., Guilherme, Adilson, Kelly, Mark, Chi, Jingyi, Zhang, Peng, Lifshitz, Lawrence M., Bellvé, Karl, Rowland, Leslie A., Yenilmez, Batuhan, Kumar, Shreya, Wang, Yetao, Luban, Jeremy, Weinstein, Lee S., Lin, Jiandie D., Cohen, Paul, Czech, Michael P.

“…Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in…”
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Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation by Lu, Ping, ElMallah, Mai K., Liu, Zeyu, Wu, Chan, Chen, Jun, Lifshitz, Lawrence M., ZhuGe, Ronghua

“…Bitter taste receptors (TAS2Rs) and their signaling elements are detected throughout the body, and bitter tastants induce a wide variety of biological…”
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The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach by Wu, Sijia, Fagan, Rita R, Uttamapinant, Chayasith, Lifshitz, Lawrence M, Fogarty, Kevin E, Ting, Alice Y, Melikian, Haley E

“…Presynaptic reuptake, mediated by the dopamine (DA) transporter (DAT), terminates DAergic neurotransmission and constrains extracellular DA levels. Addictive…”
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Visualization of self-delivering hydrophobically modified siRNA cellular internalization by Ly, Socheata, Navaroli, Deanna M, Didiot, Marie-Cécile, Cardia, James, Pandarinathan, Lakshmipathi, Alterman, Julia F, Fogarty, Kevin, Standley, Clive, Lifshitz, Lawrence M, Bellve, Karl D, Prot, Matthieu, Echeverria, Dimas, Corvera, Silvia, Khvorova, Anastasia

“…siRNAs are a new class of therapeutic modalities with promising clinical efficacy that requires modification or formulation for delivery to the tissue and cell…”
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Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis by Qu, Mingzi, Lu, Ping, Bellve, Karl, Lifshitz, Lawrence M., ZhuGe, Ronghua

“…Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure. The tissue injury and repair hypothesis for adenomyosis suggests that…”
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Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter by Lu, Ping, Chen, Jun, Zhang, Chenghai, Saur, Dieter, Baer, Christina E., Lifshitz, Lawrence M., Fogarty, Kevin E., ZhuGe, Ronghua

“…A persistent basal tone in the internal anal sphincter (IAS) is essential for keeping the anal canal closed and fecal continence; its inhibition via the…”
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Bitter taste receptors as targets for tocolytics in preterm labor therapy by Zheng, Kaizhi, Lu, Ping, Delpapa, Ellen, Bellve, Karl, Deng, Ruitang, Condon, Jennifer C., Fogarty, Kevin, Lifshitz, Lawrence M., Simas, Tiffany A. Moore, Shi, Fangxiong, ZhuGe, Ronghua

“…ABSTRACT Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a…”
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TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter by Lu, Ping, Lifshitz, Lawrence M., Bellve, Karl, ZhuGe, Ronghua

“…Maintenance of fecal continence requires a continuous or basal tone of the internal anal sphincter (IAS). Paradoxically, the basal tone results largely from…”
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Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis by Min, Kyounghee, Yenilmez, Batuhan, Kelly, Mark, Echeverria, Dimas, Elleby, Michael, Lifshitz, Lawrence M, Raymond, Naideline, Tsagkaraki, Emmanouela, Harney, Shauna M, DiMarzio, Chloe, Wang, Hui, McHugh, Nicholas, Bramato, Brianna, Morrison, Brett, Rothstein, Jeffery D, Khvorova, Anastasia, Czech, Michael P

“…Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed,…”
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The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness by Zhang, Cheng-Hai, Li, Yinchuan, Zhao, Wei, Lifshitz, Lawrence M, Li, Hequan, Harfe, Brian D, Zhu, Min-Sheng, ZhuGe, Ronghua

“…Asthma is a chronic inflammatory disorder with a characteristic of airway hyperresponsiveness (AHR). Ca(2+)-activated Cl(-) [Cl((Ca))] channels are inferred to…”
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The Transmembrane Protein 16A Ca2+ activated Cl― Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness by ZHANG, Cheng-Hai, YINCHUAN LI, WEI ZHAO, LIFSHITZ, Lawrence M, HEQUAN LI, HARFE, Brian D, ZHU, Min-Sheng, RONGHUA ZHUGE

“…Rationale : Asthma is a chronic inflammatory disorder with a characteristic of airway hyperresponsiveness (AHR). Ca 2+ -activated Cl − [Cl (Ca) ] channels are…”
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Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis by Navaroli, Deanna M, Bellvé, Karl D, Standley, Clive, Lifshitz, Lawrence M, Cardia, James, Lambright, David, Leonard, Deborah, Fogarty, Kevin E, Corvera, Silvia

“…Cell surface receptors and other proteins internalize through diverse mechanisms at the plasma membrane and are sorted to different destinations. Different…”
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Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus by Rojas-Rodriguez, Raziel, Lifshitz, Lawrence M., Bellve, Karl D., Min, So Yun, Pires, Jacqueline, Leung, Katherine, Boeras, Crina, Sert, Aylin, Draper, Jacqueline T., Corvera, Silvia, Moore Simas, Tiffany A.

“…Aims/hypothesis During pregnancy, adipose tissue (AT) must expand to support the growing fetus and the future nutritional needs of the offspring. Limited…”
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The molecular basis of the genesis of basal tone in internal anal sphincter by Zhang, Cheng-Hai, Wang, Pei, Liu, Dong-Hai, Chen, Cai-Ping, Zhao, Wei, Chen, Xin, Chen, Chen, He, Wei-Qi, Qiao, Yan-Ning, Tao, Tao, Sun, Jie, Peng, Ya-Jing, Lu, Ping, Zheng, Kaizhi, Craige, Siobhan M., Lifshitz, Lawrence M., Keaney Jr, John F., Fogarty, Kevin E., ZhuGe, Ronghua, Zhu, Min-Sheng

“…Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to…”
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The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking by Navaroli, Deanna M, Stevens, Zachary H, Uzelac, Zeljko, Gabriel, Luke, King, Michael J, Lifshitz, Lawrence M, Sitte, Harald H, Melikian, Haley E

“…Dopaminergic signaling and plasticity are essential to numerous CNS functions and pathologies, including movement, cognition, and addiction. The amphetamine-…”
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