Search Results - "Life sciences (1973)"

PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond by Fattahi, Sadegh, Amjadi-Moheb, Fatemeh, Tabaripour, Reza, Ashrafi, Gholam Hossein, Akhavan-Niaki, Haleh

“…PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved in normal cellular processes. Its aberrant activation modulates autophagy,…”
Get full text

Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease by Kesika, Periyanaina, Suganthy, Natarajan, Sivamaruthi, Bhagavathi Sundaram, Chaiyasut, Chaiyavat

“…Gut microbiota represents a diverse and dynamic population of microorganisms harboring the gastrointestinal tract, which influences the host health and…”
Get full text

Cancer stem cell (CSC) resistance drivers by Najafi, Masoud, Mortezaee, Keywan, Majidpoor, Jamal

“…Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic potency. CSCs can adopt easily with changes in the nearby milieu, and are…”
Get full text

A comprehensive review on time-tested anticancer drug doxorubicin by Sritharan, Sruthi, Sivalingam, Nageswaran

“…Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for treating a myriad of cancers. It induces cell death through multiple…”
Get full text

Men and mice: Relating their ages by Dutta, Sulagna, Sengupta, Pallav

“…Since the late 18th century, the murine model has been widely used in biomedical research (about 59% of total animals used) as it is compact, cost-effective,…”
Get full text

Autophagy: The spotlight for cellular stress responses by Ravanan, Palaniyandi, Srikumar, Ida Florance, Talwar, Priti

“…Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal physiological processes including removing of long lived, aggregated and…”
Get full text

Toxicity of Doxorubicin (Dox) to different experimental organ systems by Pugazhendhi, Arivalagan, Edison, Thomas Nesakumar Jebakumar Immanuel, Velmurugan, Bharath Kumar, Jacob, Joe Antony, Karuppusamy, Indira

“…Doxorubicin (Dox) is a valuable anticancer drug for hematologic and solid tumors. Yet, it can cause multi-organ toxicities in various patients. Since toxicity…”
Get full text

Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy by Ramaiah, M. Janaki, Tangutur, Anjana Devi, Manyam, Rajasekhar Reddy

“…The role of genetic and epigenetic factors in tumor initiation and progression is well documented. Histone deacetylases (HDACs), histone methyl transferases…”
Get full text

Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer by Bagheri, Elnaz, Abnous, Khalil, Farzad, Sara Amel, Taghdisi, Seyed Mohammad, Ramezani, Mohammad, Alibolandi, Mona

“…Exosomes hold great potential for cancer treatment to deliver therapeutics due to its inherent low immunogenicity. Exosomes are biocompatible cell-exocytosed…”
Get full text

LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53 by Lu, Jingjing, Xu, Feng, Lu, Hong

“…The study aims to investigate the roles of LncRNA and miRNA in ferroptosis in brain ischemia/reperfusion (I/R) in vivo and in vitro. qPCR assay was used to…”
Get full text

Naringenin: A potential flavonoid phytochemical for cancer therapy by Motallebi, Mahzad, Bhia, Mohammed, Rajani, Huda Fatima, Bhia, Iman, Tabarraei, Hadi, Mohammadkhani, Niloufar, Pereira-Silva, Miguel, Kasaii, Maryam Sadat, Nouri-Majd, Saeedeh, Mueller, Anna-Lena, Veiga, Francisco J.B., Paiva-Santos, Ana Cláudia, Shakibaei, Mehdi

Get full text

Gene therapy: Comprehensive overview and therapeutic applications by Sayed, Nilofer, Allawadhi, Prince, Khurana, Amit, Singh, Vishakha, Navik, Umashanker, Pasumarthi, Sravan Kumar, Khurana, Isha, Banothu, Anil Kumar, Weiskirchen, Ralf, Bharani, Kala Kumar

“…Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene…”
Get full text

Mitochondrial dysfunction in obesity by de Mello, Aline Haas, Costa, Ana Beatriz, Engel, Jéssica Della Giustina, Rezin, Gislaine Tezza

“…Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen…”
Get full text

High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes by Rizwan, Huma, Pal, Sweta, Sabnam, Silpa, Pal, Arttatrana

“…Mitochondria are fascinating structures of the cellular compartments that generate energy to run the cells. However, inherent disorders of mitochondria due to…”
Get full text

CRISPR-Cas9 system: A new-fangled dawn in gene editing by Gupta, Darshana, Bhattacharjee, Oindrila, Mandal, Drishti, Sen, Madhab Kumar, Dey, Dhritiman, Dasgupta, Adhiraj, Kazi, Tawsif Ahmed, Gupta, Rahul, Sinharoy, Senjuti, Acharya, Krishnendu, Chattopadhyay, Dhrubajyoti, Ravichandiran, V., Roy, Syamal, Ghosh, Dipanjan

“…Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced…”
Get full text

Revisiting the role of neurotransmitters in epilepsy: An updated review by Akyuz, Enes, Polat, Ayse Kristina, Eroglu, Ece, Kullu, Irem, Angelopoulou, Efthalia, Paudel, Yam Nath

“…Epilepsy is a neurologicaldisorder characterized by persistent predisposition to recurrent seizurescaused by abnormal neuronal activity in the brain. Epileptic…”
Get full text

Recent trends in cancer therapy: A review on the current state of gene delivery by Yahya, Esam Bashir, Alqadhi, Amaal Mohammed

“…Cancer treatment has been always considered one of the most critical and vital themes of clinical issues. Many approaches have been developed, depending on the…”
Get full text

New molecular and biochemical insights of doxorubicin-induced hepatotoxicity by Prasanna, Pureti Lakshmi, Renu, Kaviyarasi, Valsala Gopalakrishnan, Abilash

“…Chemotherapeutic antibiotic doxorubicin belongs to the anthracycline class, slaughters not only the cancer cells but also non-cancerous cells even in the…”
Get full text

Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome by Wang, Juan, Wu, Daichao, Guo, Hui, Li, Meixiang

“…Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive endocrine diseases, which has a variety of effects on a woman's health…”
Get full text

Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs by Khan, Kifayat Ullah, Minhas, Muhammad Usman, Badshah, Syed Faisal, Suhail, Muhammad, Ahmad, Aousaf, Ijaz, Shakeel

“…Poor aqueous solubility and poor bioavailability are major issues with many pharmaceutical industries. By some estimation, 70–90% drug candidates in…”
Get full text