Immunosuppression, tonsillectomy and remissions in high-risk IgA-nephropathy

Immunosuppression, tonsillectomy and remissions in high-risk IgA-nephropathy

To evaluate the efficacy of immunosuppressive therapy (IST) and tonsillectomy (TE) in patients with high-risk IgA nephropathy (IgAN). Materials and мethods. The retrospective study cohort included cases with primary IgAN ( =213, age 34±11 years, male 52%) at high risk of progression with clinical an...

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Bibliographic Details
Published in:Terapevtic̆eskii arhiv Vol. 96; no. 6; pp. 600 - 605
Main Authors: Kochoyan, Z S, Lieva, A Z, Galkovskaya, T O, Dobronravov, V A
Format: Journal Article
Language:English
Russian
Published: Russia (Federation) 07-07-2024
Subjects:
Adult
Female
Glomerulonephritis, IGA - drug therapy
Glomerulonephritis, IGA - surgery
Humans
Immunosuppression Therapy - methods
Immunosuppressive Agents - administration & dosage
Male
Middle Aged
Remission Induction - methods
Retrospective Studies
Tonsillectomy - methods
treatment
immunosuppression
tonsillectomy
immunoglobulin A nephropathy
remissions
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Summary:To evaluate the efficacy of immunosuppressive therapy (IST) and tonsillectomy (TE) in patients with high-risk IgA nephropathy (IgAN). Materials and мethods. The retrospective study cohort included cases with primary IgAN ( =213, age 34±11 years, male 52%) at high risk of progression with clinical and morphological data collected. The follow-up was 26 (10; 61) months. The association of IST without TE (IST; =141) or with TE (IST+TE; =72) with the development of complete (PR), partial (PR) and overall (PR or PR, OR) remissions was investigated. The incidence of achieving early PR or OR in the IST and IST+TE groups was 65.2% and 86.1%, respectively ( =0.002). The probability of early PR or OR was significantly increased in the IST+TE group compared to IST [HR 1.714 (1.214-2.420) and HR 3.410 (1.309-8.880), respectively]. IST+TE was associated with a 3- to 4-fold increase in the likelihood of PR or OR at the end of follow-up [HR 2.575 (1.679-3.950) and HR 4.768 (2.434-9.337), respectively]. Analyses using pseudorandomisation methods yielded similar results. TE may be effective for remission induction in high-risk IgAN.
Bibliography:ObjectType-Article-2
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ISSN:0040-3660
2309-5342
DOI:10.26442/00403660.2024.06.202728