Search Results - "Lieu, Linda B"

Leveraging Ion–Ion and Ion–Photon Activation to Improve the Sequencing of Proteins Carrying Multiple Disulfide Bonds: The Human Serum Albumin Case Study by Lieu, Linda B., Hinkle, Joshua D., Syka, John E. P., Fornelli, Luca

“…Gas-phase sequencing of large intact proteins (>30 kDa) via tandem mass spectrometry is an inherently challenging process that is further complicated by the…”
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Characterization of a Monoclonal Antibody by Native and Denaturing Top-Down Mass Spectrometry by Oates, Ryan N., Lieu, Linda B., Srzentić, Kristina, Damoc, Eugen, Fornelli, Luca

“…Established in recent years as an important approach to unraveling the heterogeneity of intact monoclonal antibodies, native mass spectrometry has been rarely…”
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Enhanced Payload Localization in Antibody–Drug Conjugates Using a Middle-Down Mass Spectrometry Approach with Proton Transfer Charge Reduction by Lieu, Linda B., Nagy, Cynthia, Huang, Jingjing, Mullen, Christopher, McAlister, Graeme C., Zabrouskov, Vlad, Srzentić, Kristina, Durbin, Kenneth R., Melani, Rafael D., Fornelli, Luca

“…Antibody–drug conjugates (ADCs) represent a novel class of immunoconjugates with growing therapeutic relevance, since they combine the efficacy of cytotoxic…”
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Towards a universal method for middle-down analysis of antibodies via proton transfer charge reduction—Orbitrap mass spectrometry by Oates, Ryan N., Lieu, Linda B., Kline, Jake T., Mullen, Christopher, Srzentić, Kristina, Huguet, Romain, McAlister, Graeme C., Huang, Jingjing, Bergen, David, Melani, Rafael D., Zabrouskov, Vlad, Durbin, Kenneth R., Syka, John E. P., Fornelli, Luca

“…Modern mass spectrometry technology allows for extensive sequencing of the ~ 25 kDa subunits of monoclonal antibodies (mAbs) produced by IdeS proteolysis…”
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Top-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction by Kline, Jake T, Huang, Jingjing, Lieu, Linda B, Srzentić, Kristina, Bergen, David, Mullen, Christopher, McAlister, Graeme C, Durbin, Kenneth R, Melani, Rafael D, Fornelli, Luca

“…Adeno-associated viruses (AAVs) are common vectors for emerging gene therapies due to their lack of pathogenicity in humans. Here, we present our investigation…”
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