ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin...

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Published in:	Hormone and metabolic research Vol. 49; no. 5; p. 343
Main Authors:	von Loeffelholz, Christian, Pfeiffer, Andreas F H, Lock, Johan F, Lieske, Steffi, Döcke, Stephanie, Murahovschi, Veronica, Kriebel, Jennifer, de Las Heras Gala, Tonia, Grallert, Harald, Rudovich, Natalia, Stockmann, Martin, Spranger, Joachim, Jahreis, Gerhard, Bornstein, Stefan R, Lau, George, Xu, Aimin, Schulz-Menger, Jeanette, Exner, Louisa, Haufe, Sven, Jordan, Jens, Engeli, Stefan, Birkenfeld, Andreas L
Format:	Journal Article
Language:	English
Published:	Germany 01-05-2017
Subjects:	Angiopoietin-like Proteins - genetics Angiopoietin-like Proteins - metabolism Cohort Studies Diet Fatty Liver - genetics Female Humans Intra-Abdominal Fat - metabolism Male Middle Aged Non-alcoholic Fatty Liver Disease - genetics Peptide Hormones - genetics Peptide Hormones - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism
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Summary:	Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=-0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.
ISSN:	1439-4286
DOI:	10.1055/s-0043-102950