Search Results - "Lier, René A.W."

Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients by Oja, Anna E., Saris, Anno, Ghandour, Cherien A., Kragten, Natasja A.M., Hogema, Boris M., Nossent, Esther J., Heunks, Leo M.A., Cuvalay, Susan, Slot, Ed, Linty, Federica, Swaneveld, Francis H., Vrielink, Hans, Vidarsson, Gestur, Rispens, Theo, Schoot, Ellen, Lier, René A.W., Ten Brinke, Anja, Hombrink, Pleun

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding…”
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The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells by Chang, Gin-Wen, Hsiao, Cheng-Chih, Peng, Yen-Ming, Vieira Braga, Felipe A., Kragten, Natasja A.M., Remmerswaal, Ester B.M., van de Garde, Martijn D.B., Straussberg, Rachel, König, Gabriele M., Kostenis, Evi, Knäuper, Vera, Meyaard, Linde, van Lier, René A.W., van Gisbergen, Klaas P.J.M., Lin, Hsi-Hsien, Hamann, Jörg

“…Natural killer (NK) cells possess potent cytotoxic mechanisms that need to be tightly controlled. Here, we explored the regulation and function of…”
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Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions by van Lier, René A.W, Baars, Paul A, van Oers, Marinus H.J, Tesselaar, Kiki, Arens, Ramon, van der Valk, Martin A, Borst, Jannie, van Schijndel, Gijs M.W

“…It has been proposed that HIV-1, in addition to directly infecting and killing CD4+ T cells, causes T cell dysfunction and T cell loss by chronic immune…”
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Specific expression of GPR56 by human cytotoxic lymphocytes by Peng, Yen‐Ming, Garde, Martijn D. B., Cheng, Kai‐Fong, Baars, Paul A., Remmerswaal, Ester B. M., Lier, René A.W., Mackay, Charles R., Lin, Hsi‐Hsien, Hamann, Jörg

“…GPR56 belongs to a new cluster of adhesion‐GPCRs on human immune cells and is expressed with high specificity by cytotoxic lymphocytes. We here report the…”
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Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology by Nolte, Martijn A, van Olffen, Ronald W, van Gisbergen, Klaas P.J.M, van Lier, René A.W

“…After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis factor receptor (TNFR)-associated factor-binding member of the…”
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Molecular characterization of HCMV‐specific immune responses: Parallels between CD8+ T cells, CD4+ T cells, and NK cells by Vieira Braga, Felipe A., Hertoghs, Kirsten M. L., Lier, René A.W., Gisbergen, Klaas P. J. M.

“…CD8+ T cells are important for immunity against human cytomegalovirus (HCMV). The HCMV‐specific CD8+ T‐cell response is characterized by the accumulation of…”
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The Cellular Immune System Comes of Age by van Lier, René A.W, Kuijpers, Taco W

“…[...]it has become evident that a subset of the initially activated pool of T cells takes up permanent residency in solid tissue, such as the gut, skin, and…”
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Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung by de Bree, Godelieve J, van Leeuwen, Ester M M, Out, Theo A, Jansen, Henk M, Jonkers, René E, van Lier, René A W

“…The lungs are frequently challenged by viruses, and resident CD8(+) T cells likely contribute to the surveillance of these pathogens. To obtain insight into…”
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Phenotypic and functional separation of memory and effector human CD8+ T cells by Hamann, D, Baars, P A, Rep, M H, Hooibrink, B, Kerkhof-Garde, S R, Klein, M R, van Lier, R A

“…Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be…”
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Skewed maturation of virus-specific CTLs? by Gamadia, Laila E, Ten Berge, Ineke J. M, Picker, Louis J, van Lier, René A.W

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Human T-cell memory consists mainly of unexpanded clones by Klarenbeek, Paul L, Tak, Paul P, van Schaik, Barbera D.C, Zwinderman, Aeilko H, Jakobs, Marja E, Zhang, Zhuoli, van Kampen, Antoine H.C, van Lier, René A.W, Baas, Frank, de Vries, Niek

“…Abstract The immune system is able to respond to millions of antigens using adaptive receptors, including the αβ-T-cell receptor (TCR). Upon antigen encounter…”
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Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation by Arens, Ramon, Schepers, Koen, Nolte, Martijn A, van Oosterwijk, Michiel F, van Lier, René A W, Schumacher, Ton N M, van Oers, Marinus H J

“…In vivo priming of antigen-specific CD8+ T cells results in their expansion and differentiation into effector T cells followed by contraction into a memory T…”
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Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion by Arens, Ramon, Tesselaar, Kiki, Baars, Paul A, van Schijndel, Gijs M.W, Hendriks, Jenny, Pals, Steven T, Krimpenfort, Paul, Borst, Jannie, van Oers, Marinus H.J, van Lier, René A.W

“…The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly…”
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CD27–CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development by van Oosterwijk, Michiel F., Juwana, Hedi, Arens, Ramon, Tesselaar, Kiki, van Oers, Marinus H. J., Eldering, Eric, van Lier, René A. W.

“…Stimulation of CD27, a member of the tumour necrosis factor receptor family, by its ligand CD70 induces expansion of IFNγ secreting CD4+ and CD8+ T cells in…”
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The interaction between cytomegalovirus and the human immune system by ten Berge, Ineke J.M, van Lier, René A.W

“…Abstract Studies on antiviral immunity in man are hampered by the impossibility to standardize the infection as is done in experimental animal studies. An…”
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Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells by van Aalderen, Michiel C., van den Biggelaar, Maartje, Remmerswaal, Ester B.M., van Alphen, Floris P.J., Meijer, Alexander B., ten Berge, Ineke J.M., van Lier, René A.W.

“…Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we…”
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A fingerprint left by cytomegalovirus infection in the human T cell compartment by van de Berg, Pablo J.E.J, van Stijn, Amber, ten Berge, Ineke J.M, van Lier, René A.W

“…Abstract Latent infection with human cytomegalovirus (HCMV) is accompanied by a strong increase in the number of resting, effector-type CD4+ and CD8+ T cells…”
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Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis by aan de Kerk, Daan J, van Leeuwen, Ester M.M, Jansen, Machiel H, van den Berg, J. Merlijn, Alders, Marielle, Vermont, Clementine L, van Lier, René A.W, Pals, Steven T, Kuijpers, Taco W

“…Abstract Mutations in the DOCK8 gene define the most common form of autosomal-recessive Hyper-IgE-syndrome (AR-HIES/OMIM#243700). In a patient with extensive…”
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Common γ chain cytokines: Dissidence in the details by Alves, Nuno L, Arosa, Fernando A, van Lier, René A.W

“…Abstract Cytokines of the common cytokine-receptor γ-chain (γc ) family are essential for the development and maintenance of lymphocytes. Herein, we will focus…”
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CD8 and CD4 T Cell Populations in Human Kidneys by van der Putten, Carlos, Remmerswaal, Ester B M, Terpstra, Matty L, van der Bom, Nelly D, Kers, Jesper, Ten Berge, Ineke J M, Geerlings, Suzanne E, van Lier, René A W, Bemelman, Frederike J, van Aalderen, Michiel C

“…At border sites, and in internal organs, tissue resident memory T cells (T contribute to the immune barrier against pathogens like viruses, bacteria, fungi,…”
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