Search Results - "Lienard, Philippe"

Development and Validation of a Kilogram-Scale Synthesis of Tirapazamine by Lienard, Philippe, Elenbaas, Steven

“…The process selection and subsequent development of a reliable, scalable synthesis of the anticancer prodrug tirapazamine (SR259075) is described in this…”
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Pilot Scale Process Development of SL65.0102-10, an N‑Diazabicyclo[2.2.2]-octylmethyl Benzamide by Lienard, Philippe, Gradoz, Philippe, Greciet, Hélène, Jegham, Samir, Legroux, Didier

“…The process development and improvements for route selection, adapted to large scale for the pilot-scale preparation of SL65.0102-10, an…”
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Abstract 130: Pharmacological effects of selective xCT inhibition in ARID1A mutated cancer models by Henry, Christophe, Péron, Philippe, Blanchet, Anne-Marie, Genevois-Borella, Arielle, Trellu, Marc, Bourges, Dorothée, Lienard, Philippe, Basset, Alexandra, Jouannot, Erwan, Philippo, Christophe, Debussche, Laurent, Moll, Jürgen

“…Abstract xCT is a cystine/glutamate antiporter that exports intracellular glutamate for extracellular cystine. In the intracellular space, cystine is converted…”
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Abstract 6033: RA123, a new GLS1 allosteric inhibitor demonstrates in vitro and in vivo activity in multiple myeloma models by Henry, Christophe, Gorge-Bernat, Dimitri, Pannier, Pascal, Meaux, Isabelle, Cheng, Jane, Sun, Fangxian, Pasquier, Olivier, Lienard, Philippe, Jouannot, Erwan, Gouyon, Thierry, Estenne-Bouhtou, Geneviève, Zhang, Bailin, Thiers, Bérangère, Debussche, Laurent, Machnik, David

“…Abstract The conditional essential amino acid glutamine is utilized by tumors to sustain bioenergetic requirements in a nutrient-poor microenvironment. Based…”
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Physical dynamics of sludges during wine fermentation in liquid phase by Erick Casalta, Evelyne Aguera, Philippe Liénard, Jean-Michel Salmon

“…Aims: The aim of this work was to study the dynamics of the sludge particles during wine fermentation in liquid phase. Methods and results: Ninety L of…”
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Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors by Weiberth, Franz J, Gill, Harpal S, Jiang, Ying, Lee, George E, Lienard, Philippe, Pemberton, Clive, Powers, Matthew R, Subotkowski, Witold, Tomasik, Witold, Vanasse, Benoit J, Yu, Yong

“…Route selection, process development and large-scale preparation of selectively benzoylated and fluorinated d-glucopyranoses, required as glycosyl donors for…”
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In silico assessment of drug substances chemical stability by Kieffer, Jérôme, Brémond, Éric, Lienard, Philippe, Boccardi, Giovanni

“…The chemical stability of active pharmaceutical ingredients (API) can be studied by physico-chemical stress tests but the interpretation of the results is…”
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Aza-dibenzocyclooctadiene analogue of stegane via the CN(R,S) method by Lienard, Philippe, Saint-Jalmes, Bernadette, Quirion, Jean-Charles

“…The optically pure 2-benzylpiperidine 4 obtained from synthon 2-cyano-6-phenyloxazolopiperidine (−) 3 via the CN(R, S) method, gave after N-alkylation, the…”
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