Search Results - "Lien, Karen"

KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction by De Lorenzo, Silvana B, Vrieze, Alyssa M, Johnson, Ruth A, Lien, Karen R, Nath, Karl A, Garovic, Vesna D, Khazaie, Khashayarsha, Grande, Joseph P

“…Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways…”
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Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension by Kashyap, Sonu, Osman, Mazen, Ferguson, Christopher M., Nath, Meryl C., Roy, Bhaskar, Lien, Karen R., Nath, Karl A., Garovic, Vesna D., Lerman, Lilach O., Grande, Joseph P.

“…Inflammation plays an important role in the pathogenesis of renal and cardiovascular disease in renovascular hypertension (RVH). Ccl2 is an important mediator…”
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Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension by Kashyap, Sonu, Warner, Gina, Hu, Zeng, Gao, Feng, Osman, Mazen, Al Saiegh, Yousif, Lien, Karen R, Nath, Karl, Grande, Joseph P

“…Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic…”
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Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress by Thompson, Scott M, Callstrom, Matthew R, Jondal, Danielle E, Butters, Kim A, Knudsen, Bruce E, Anderson, Jill L, Lien, Karen R, Sutor, Shari L, Lee, Ju-Seog, Thorgeirsson, Snorri S, Grande, Joseph P, Roberts, Lewis R, Woodrum, David A

“…Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger…”
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Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model by Wang, Diping, Warner, Gina M, Yin, Ping, Knudsen, Bruce E, Cheng, Jingfei, Butters, Kim A, Lien, Karen R, Gray, Catherine E, Garovic, Vesna D, Lerman, Lilach O, Textor, Stephen C, Nath, Karl A, Simari, Robert D, Grande, Joseph P

“…Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Recent studies have underscored a critical role for CCL2 (MCP-1)-mediated…”
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The Role of Apathy and Depression on Verbal Learning and Memory Performance After Stroke by Fishman, Keera N, Ashbaugh, Andrea R, Lanctôt, Krista L, Cayley, Megan L, Herrmann, Nathan, Murray, Brian J, Sicard, Michelle, Lien, Karen, Sahlas, Demetrios J, Swartz, Richard H

“…Abstract Objective Psychiatric symptoms, including depression and apathy, may significantly impede functional and cognitive capabilities following a…”
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Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension by Kashyap, Sonu, Warner, Gina M, Hartono, Stella P, Boyilla, Rajendra, Knudsen, Bruce E, Zubair, Adeel S, Lien, Karen, Nath, Karl A, Textor, Stephen C, Lerman, Lilach O, Grande, Joseph P

“…Renovascular hypertension (RVH) is a common cause of both cardiovascular and renal morbidity and mortality. In renal artery stenosis (RAS), atrophy in the…”
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The "DOC" screen: Feasible and valid screening for depression, Obstructive Sleep Apnea (OSA) and cognitive impairment in stroke prevention clinics by Swartz, Richard H, Cayley, Megan L, Lanctôt, Krista L, Murray, Brian J, Cohen, Ashley, Thorpe, Kevin E, Sicard, Michelle N, Lien, Karen, Sahlas, Demetrios J, Herrmann, Nathan

“…Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and poorer quality…”
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Language discordance as a marker of disparities in cerebrovascular risk and stroke outcomes: A multi-center Canadian study by Muir, Ryan T., Kapoor, Arunima, Cayley, Megan L., Sicard, Michelle N, Lien, Karen, Southwell, Alisia, Dowlatshahi, Dar, Sahlas, Demetrios J., Saposnik, Gustavo, Mandzia, Jennifer, Casaubon, Leanne K., Hassan, Ayman, Perez, Yael, Selchen, Daniel, Murray, Brian J., Lanctot, Krista, Kapral, Moira K., Herrmann, Nathan, Strother, Stephen, Yu, Amy．Y．X, Austin, Peter C., Bronskill, Susan E., Swartz, Richard H.

“…•Language discordance (when a patient's primary spoken language differs from the primary language of the health system) is associated with worse post-stroke…”
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In utero cell transfer between porcine littermates by McConico, Andrea, Butters, Kim, Lien, Karen, Knudsen, Bruce, Wu, Xiaosheng, Platt, Jeffrey L, Ogle, Brenda M

“…Trafficking of cells between mother and fetus during the course of normal pregnancy is well documented. Similarly, cells are known to travel between twins that…”
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Adjusting for Drug Wastage in Economic Evaluations of New Therapies for Hematologic Malignancies: A Systematic Review by Lien, Karen, Cheung, Matthew C, Chan, Kelvin K W

“…As costs of cancer care rise, there has been a shift to focus on value. Drug wastage affects costs to patients and health care systems without adding value…”
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Gene Expression Profiles Indicative of Reversible Injury in Experimental Renal Artery Stenosis by Osman, Mazen, De Lorenzo, Silvana, Johnson, Ruth, Lien, Karen, Grande, Joseph

“…Abstract only…”
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Genetic Deficiency of T‐bet Protects Against Chronic Renal Injury in Murine Renal Artery Stenosis by Osman, Mazen, Osman, Adam, Kashyap, Sonu, Taha, Hula, Lien, Karen, Grande, Joseph

“…Aim Th1 cells have potent pro‐inflammatory properties and have been shown to play an important role in the development and progression of acute renal injury to…”
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Histopathologic Correlates of Irreversible Renal Injury in Renal Artery Stenosis by Osman, Mazen, Sonu, Kashyap, Kaya, Osman, Hu, Zeng, Karen, Lien, Grande, Joseph Peter

“…Aim The aim of this study was to define the functional correlates of reversibilitiy following restoration of blood flow in the murine 2K1C model of…”
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Symptoms of depression and cognitive impairment in young adults after stroke/transient ischemic attack by Kapoor, Arunima, Scott, Courtney, Lanctot, Krista L., Herrmann, Nathan, Murray, Brian J., Thorpe, Kevin E., Lien, Karen, Sicard, Michelle, Swartz, Richard H.

“…•This study highlights age differences in post-stroke depression and cognitive impairment.•Young stroke survivors are more likely to experience symptoms of…”
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Post-stroke depression, obstructive sleep apnea, and cognitive impairment: Rationale for, and barriers to, routine screening by Swartz, Richard H, Bayley, Mark, Lanctôt, Krista L, Murray, Brian J, Cayley, Megan L, Lien, Karen, Sicard, Michelle N, Thorpe, Kevin E, Dowlatshahi, Dar, Mandzia, Jennifer L, Casaubon, Leanne K, Saposnik, Gustavo, Perez, Yael, Sahlas, Demetrios J, Herrmann, Nathan

“…Stroke can cause neurological impairment ranging from mild to severe, but the impact of stroke extends beyond the initial brain injury to include a complex…”
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Men Are at Higher Risk of Screening Positive for Vascular Cognitive Impairment Compared to Women after Stroke and Transient Ischemic Attack by Zinman, Julia, Kapoor, Arunima, Si, Kevin, Sujanthan, Sajeevan, Southwell, Alisia, Cayley, Megan L, Sicard, Michelle N, Lien, Karen, Murray, Brian J, Lanctôt, Krista, Herrmann, Nathan, Dowlatshahi, Dar, Sahlas, Demetrios J, Saposnik, Gustavo, Mandzia, Jennifer L, Casaubon, Leanne K, Hassan, Ayman, Perez, Yael, Swartz, Richard H

“…While women have greater incidence of dementia, men have higher prevalence of vascular risk factors. This study examined sex differences in risk of screening…”
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Language Proficiency is a Marker of Vascular Risk and Ischemic Stroke Severity (2246) by Muir, Ryan T., Kapoor, Arunima, Lanctot, Krista, Cayley, Megan L., Sicard, Michelle, Lien, Karen, Dowlatshahi, Dariush, Sahlas, Demetrios J., Saposnik, Gustavo, Mandzia, Jennifer, Casaubon, Leanne K., Hassan, Ayman, Perez, Yael, Murray, Brian J., Thorpe, Kevin E., Kapral, Moira, Strother, Stephen, Yu, Amy Y. X., Austin, Peter C., Bronskill, Susan, Hermann, Nathan, Swartz, Richard H.

“…Abstract only…”
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Apathy, not depressive symptoms, as a predictor of semantic and phonemic fluency task performance in stroke and transient ischemic attack by Fishman, Keera N, Ashbaugh, Andrea R, Lanctôt, Krista L, Cayley, Megan L, Herrmann, Nathan, Murray, Brian J, Sicard, Michelle, Lien, Karen, Sahlas, Demetrios J, Swartz, Richard H

“…This study examined the relationship between apathy and cognition in patients with cerebrovascular disease. Apathy may result from damage to frontal…”
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The "DOC" screen: Feasible and valid screening for depression, Obstructive Sleep Apnea by Swartz, Richard H, Cayley, Megan L, Lanctôt, Krista L, Murray, Brian J, Cohen, Ashley, Thorpe, Kevin E, Sicard, Michelle N, Lien, Karen, Sahlas, Demetrios J, Herrmann, Nathan

“…Background Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and…”
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