Search Results - "Lien, D."

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases by Nguyen, Lien D, Ehrlich, Barbara E

“…Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term cognitive impairment, or “chemobrain”, in survivors. However, several…”
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Tuned thalamic excitation is amplified by visual cortical circuits by Lien, Anthony D, Scanziani, Massimo

“…Using optogenetics to silence the cortex, the authors show that thalamic inputs to layer 4 V1 neurons in anesthetized mice only contribute a third of the total…”
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Cortical direction selectivity emerges at convergence of thalamic synapses by Lien, Anthony D., Scanziani, Massimo

“…Detecting the direction of motion of an object is essential for our representation of the visual environment. The visual cortex is one of the main stages in…”
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Distinct recurrent versus afferent dynamics in cortical visual processing by Reinhold, Kimberly, Lien, Anthony D, Scanziani, Massimo

“…How intracortical recurrent circuits in mammalian sensory cortex influence dynamics of sensory representation is not understood. Previous methods could not…”
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Substrate-Dependent Exciton Diffusion and Annihilation in Chemically Treated MoS2 and WS2 by Goodman, A. J., Lien, D.-H., Ahn, G. H., Spiegel, L. L., Amani, M., Willard, A. P., Javey, A., Tisdale, W. A.

“…Atomically thin semiconductors such as monolayer MoS2 and WS2 exhibit nonlinear exciton–exciton annihilation at notably low excitation densities (below ~10…”
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Pharmacological rescue of cognitive function in a mouse model of chemobrain by Nguyen, Lien D, Fischer, Tom T, Ehrlich, Barbara E

“…After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as "chemobrain." However, the trajectories of…”
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Genomic signatures of heterokaryosis in the oomycete pathogen Bremia lactucae by Fletcher, Kyle, Gil, Juliana, Bertier, Lien D., Kenefick, Aubrey, Wood, Kelsey J., Zhang, Lin, Reyes-Chin-Wo, Sebastian, Cavanaugh, Keri, Tsuchida, Cayla, Wong, Joan, Michelmore, Richard

“…Lettuce downy mildew caused by Bremia lactucae is the most important disease of lettuce globally. This oomycete is highly variable and rapidly overcomes…”
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Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome by Nguyen, Lien D., Fischer, Tom T., Abreu, Damien, Arroyo, Alfredo, Urano, Fumihiko, Ehrlich, Barbara E.

“…Wolfram syndrome is a rare multisystem disease characterized by childhood-onset diabetes mellitus and progressive neurodegeneration. Most cases are attributed…”
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Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex by Saleem, Aman B., Lien, Anthony D., Krumin, Michael, Haider, Bilal, Rosón, Miroslav Román, Ayaz, Asli, Reinhold, Kimberly, Busse, Laura, Carandini, Matteo, Harris, Kenneth D.

“…Primary visual cortex exhibits two types of gamma rhythm: broadband activity in the 30–90 Hz range and a narrowband oscillation seen in mice at frequencies…”
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Comparative genomics of downy mildews reveals potential adaptations to biotrophy by Fletcher, Kyle, Klosterman, Steven J, Derevnina, Lida, Martin, Frank, Bertier, Lien D, Koike, Steven, Reyes-Chin-Wo, Sebastian, Mou, Beiquan, Michelmore, Richard

“…Spinach downy mildew caused by the oomycete Peronospora effusa is a significant burden on the expanding spinach production industry, especially for organic…”
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Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development by Fischer, Tom T., Nguyen, Lien D., Ehrlich, Barbara E.

“…Calcium (Ca2+) signaling is critical for neuronal functioning and requires the concerted interplay of numerous Ca2+‐binding proteins, including neuronal…”
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Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing by Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.

“…MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or…”
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High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce ( Lactuca sativa ) by Bertier, Lien D, Ron, Mily, Huo, Heqiang, Bradford, Kent J, Britt, Anne B, Michelmore, Richard W

“…CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary…”
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Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome by Fischer, Tom T., Nguyen, Lien D., Ehrlich, Barbara E.

“…•Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium…”
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Characterization of NCS1–InsP3R1 interaction and its functional significance by Nguyen, Lien D., Petri, Edward T., Huynh, Larry K., Ehrlich, Barbara E.

“…Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are endoplasmic reticulum–localized channels that mediate Ca2+ release from the endoplasmic reticulum into the…”
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Small Molecule Drugs Targeting Non-Coding RNAs as Treatments for Alzheimer's Disease and Related Dementias by Nguyen, Lien D, Chau, Rachel K, Krichevsky, Anna M

“…Despite the enormous burden of Alzheimer's disease and related dementias (ADRD) on patients, caregivers, and society, only a few treatments with limited…”
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Genetics of Partial Resistance Against Verticillium dahliae Race 2 in Wild and Cultivated Lettuce by Sandoya, Germán V, Truco, Maria José, Bertier, Lien D, Subbarao, Krishna V, Simko, Ivan, Hayes, Ryan J, Michelmore, Richard W

“…Lettuce ( ) is one of the most economically important vegetables in the United States, with approximately 50% of the domestic production concentrated in the…”
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Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice by Nguyen, Lien D., Nolte, Luca G., Tan, Winston J. T., Giuvelis, Denise, Santos-Sacchi, Joseph, Bilsky, Edward, Ehrlich, Barbara E.

“…Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated…”
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Anti-diabetic xanthones from the bark of Garcinia xanthochymus by Nguyen, Chi N., Trinh, Binh T.D., Tran, Toan B., Nguyen, Le-Thu T., Jäger, Anna K., Nguyen, Lien-Hoa D.

“…[Display omitted] An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of…”
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Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 by Gey, Claudia, Kyrylenko, Sergiy, Hennig, Lothar, Nguyen, Lien-Hoa D., Büttner, Anita, Pham, Hung D., Giannis, Athanassios

“…Preventative medicine: The natural products guttiferone G and hyperforin (1) as well as the synthetic aristoforin (2) are inhibitors of human SIRT1 and SIRT2…”
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