Search Results - "Liefke, Robert"

Fine-tuning of the intracellular canonical Notch signaling pathway by Borggrefe, Tilman, Liefke, Robert

“…Notch signaling plays a pivotal role in the regulation of many fundamental cellular processes, such as proliferation, stem cell maintenance and differentiation…”
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Evolutionary adaptation of the Polycomb repressive complex 2 by Fischer, Sabrina, Weber, Lisa Marie, Liefke, Robert

“…The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes…”
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Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex by Liefke, Robert, Oswald, Franz, Alvarado, Cristobal, Ferres-Marco, Dolores, Mittler, Gerhard, Rodriguez, Patrick, Dominguez, Maria, Borggrefe, Tilman

“…Timely acquisition of cell fates and the elaborate control of growth in numerous organs depend on Notch signaling. Upon ligand binding, the core transcription…”
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SAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma by Simon, Clara, Brunke, Inka D, Stielow, Bastian, Forné, Ignasi, Steitz, Anna Mary, Geller, Merle, Rohner, Iris, Weber, Lisa Marie, Fischer, Sabrina, Jeude, Lea Marie, Huber, Theresa, Nist, Andrea, Stiewe, Thorsten, Huber, Magdalena, Buchholz, Malte, Liefke, Robert

“…Pancreatic ductal adenocarcinoma (PDAC) poses a significant threat due to its tendency to evade early detection, frequent metastasis, and the subsequent…”
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Making fundamental scientific discoveries by combining information from literature, databases, and computational tools – An example by Stielow, Bastian, Simon, Clara, Liefke, Robert

“…In recent years, the amount of available literature, data and computational tools has increased exponentially, providing opportunities and challenges to make…”
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Investigation of SAMD1 ablation in mice by Campbell, Bruce, Weber, Lisa M., Engle, Sandra J., Ozolinš, Terence R. S., Bourassa, Patricia, Aiello, Robert, Liefke, Robert

“…SAM domain-containing protein 1 (SAMD1) has been implicated in atherosclerosis, as well as in chromatin and transcriptional regulation, suggesting a versatile…”
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Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis by Lenz, Jonathan, Liefke, Robert, Funk, Julianne, Shoup, Samuel, Nist, Andrea, Stiewe, Thorsten, Schulz, Robert, Tokusumi, Yumiko, Albert, Lea, Raifer, Hartmann, Förstemann, Klaus, Vázquez, Olalla, Tokusumi, Tsuyoshi, Fossett, Nancy, Brehm, Alexander

“…The generation of lineage-specific gene expression programmes that alter proliferation capacity, metabolic profile and cell type-specific functions during…”
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SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ by Sotomska, Małgorzata, Liefke, Robert, Ferrante, Francesca, Schwederski, Heiko, Oswald, Franz, Borggrefe, Tilman

“…Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to…”
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The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells by Simon, Clara, Stielow, Bastian, Nist, Andrea, Rohner, Iris, Weber, Lisa Marie, Geller, Merle, Fischer, Sabrina, Stiewe, Thorsten, Liefke, Robert

“…The unmethylated CpG island-binding protein SAMD1 is upregulated in many human cancer types, but its cancer-related role has not yet been investigated. Here,…”
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ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-Jκ/SHARP-Mediated Repression of Notch Target Genes by Salat, Daniela, Liefke, Robert, Wiedenmann, Jörg, Borggrefe, Tilman, Oswald, Franz

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape by Liefke, Robert, Karwacki-Neisius, Violetta, Shi, Yang

“…Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs), the transcriptional network can be divided into…”
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Polycomb-like Proteins in Gene Regulation and Cancer by Fischer, Sabrina, Liefke, Robert

“…Polycomb-like proteins (PCLs) are a crucial group of proteins associated with the Polycomb repressive complex 2 (PRC2) and are responsible for setting up the…”
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Polycomb-like proteins link the PRC2 complex to CpG islands by Li, Haojie, Liefke, Robert, Jiang, Junyi, Kurland, Jesse Vigoda, Tian, Wei, Deng, Pujuan, Zhang, Weidi, He, Qian, Patel, Dinshaw J., Bulyk, Martha L., Shi, Yang, Wang, Zhanxin

“…Crystal structures of the Polycomb-like proteins PHF1 and MTF2 with bound DNA and histone peptides show that extended homologous regions of the two proteins…”
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EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape by Liefke, Robert, Karwacki-Neisius, Violetta, Shi, Yang

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The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin by Tian, Wei, Yan, Peiqiang, Xu, Ning, Chakravorty, Arghya, Liefke, Robert, Xi, Qiaoran, Wang, Zhanxin

“…HDGF-related protein 3 (HRP3, also known as HDGFL3) belongs to the family of HDGF-related proteins (HRPs) and plays an essential role in hepatocellular…”
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The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells by Liefke, Robert, Shi, Yang

“…CpG islands (CGIs) are key DNA regulatory elements in the vertebrate genome and are often found at gene promoters. In mammalian embryonic stem (ES) cells, CGIs…”
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A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells by Zuo, Feifei, Jiang, Junyi, Fu, Haipeng, Yan, Kun, Liefke, Robert, Zhang, Jing, Hong, Yaqiang, Chang, Zai, Liu, Nian, Wang, Zhanxin, Xi, Qiaoran

“…2-cell-like cells (2CLCs)-which comprise only ∼1% of murine embryonic stem cells (mESCs)-resemble blastomeres of 2-cell-stage embryos and are used to…”
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Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity by Ballaré, Cecilia, Lange, Martin, Lapinaite, Audrone, Martin, Gloria Mas, Morey, Lluis, Pascual, Gloria, Liefke, Robert, Simon, Bernd, Shi, Yang, Gozani, Or, Carlomagno, Teresa, Benitah, Salvador Aznar, Di Croce, Luciano

“…Methylation of H3K27 by Polycomb repressive complex 2 (PRC2) is essential for gene regulation. A new study provides structural evidence for the recognition of…”
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IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells by Fischer, Sabrina, Weber, Lisa Marie, Stielow, Bastian, Frech, Miriam, Simon, Clara, Geller, Merle, Könnecke, Julie, Finkernagel, Florian, Forné, Ignasi, Nist, Andrea, Bauer, Uta-Maria, Stiewe, Thorsten, Neubauer, Andreas, Liefke, Robert

“…Abstract Acute myeloid leukemia (AML) is a hematological malignancy characterized by abnormal proliferation and accumulation of immature myeloid cells in the…”
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NF‐κB p65 dimerization and DNA‐binding is important for inflammatory gene expression by Riedlinger, Tabea, Liefke, Robert, Meier-Soelch, Johanna, Jurida, Liane, Nist, Andrea, Stiewe, Thorsten, Kracht, Michael, Lienhard Schmitz, M.

“…ABSTRACT Increasing evidence shows that many transcription factors execute important biologic functions independent from their DNA‐binding capacity. The NF‐κB…”
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