Search Results - "Liedtke, Wolfgang B."

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis by Lee, Whasil, Nims, Robert J., Savadipour, Alireza, Zhang, Qiaojuan, Leddy, Holly A., Liu, Fang, McNulty, Amy L., Chen, Yong, Guilak, Farshid, Liedtke, Wolfgang B.

“…Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector, Nat. Rev…”
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Regulation of Pain and Itch by TRP Channels by Moore, Carlene, Gupta, Rupali, Jordt, Sven-Eric, Chen, Yong, Liedtke, Wolfgang B.

“…Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important…”
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TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading by O'Conor, Christopher J., Leddy, Holly A., Benefield, Halei C., Liedtke, Wolfgang B., Guilak, Farshid

“…Mechanical loading of joints plays a critical role in maintaining the health and function of articular cartilage. The mechanism(s) of chondrocyte…”
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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage by Lee, Whasil, Leddy, Holly A, Chen, Yong, Lee, Suk Hee, Zelenski, Nicole A, McNulty, Amy L, Wu, Jason, Beicker, Kellie N, Coles, Jeffrey, Zauscher, Stefan, Grandl, Jörg, Sachs, Frederick, Guilak, Farshid, Liedtke, Wolfgang B

“…Significance Cartilage, a mechanically sensitive tissue that covers joints, is essential for vertebrate locomotion by sustaining skeletal mobility…”
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TRPV4 Channels stimulate Ca²⁺-induced Ca²⁺ release in astrocytic endfeet and amplify neurovascular coupling responses by Dunn, Kathryn M., Hill-Eubanks, David C., Liedtke, Wolfgang B., Nelson, Mark T.

“…In the CNS, astrocytes are sensory and regulatory hubs that play important roles in cerebral homeostatic processes, including matching local cerebral blood…”
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch by Chen, Yong, Fang, Quan, Wang, Zilong, Zhang, Jennifer Y., MacLeod, Amanda S., Hall, Russell P., Liedtke, Wolfgang B.

“…TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to…”
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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling by Moore, Carlene, Cevikbas, Ferda, Pasolli, H Amalia, Chen, Yong, Kong, Wei, Kempkes, Cordula, Parekh, Puja, Lee, Suk Hee, Kontchou, Nelly-Ange, Yeh, Iwei, Ye, Iwei, Jokerst, Nan Marie, Fuchs, Elaine, Steinhoff, Martin, Liedtke, Wolfgang B

“…At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a…”
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Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury by Yin, Jun, Michalick, Laura, Tang, Christine, Tabuchi, Arata, Goldenberg, Neil, Dan, Qinghong, Awwad, Khader, Wang, Liming, Erfinanda, Lasti, Nouailles, Geraldine, Witzenrath, Martin, Vogelzang, Alexis, Lv, Lu, Lee, Warren L, Zhang, Haibo, Rotstein, Ori, Kapus, Andras, Szaszi, Katalin, Fleming, Ingrid, Liedtke, Wolfgang B, Kuppe, Hermann, Kuebler, Wolfgang M

“…The cation channel transient receptor potential vanilloid (TRPV) 4 is expressed in endothelial and immune cells; however, its role in acute lung injury (ALI)…”
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Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter by Yeo, Michele, Berglund, Ken, Hanna, Michael, Guo, Junjie U., Kittur, Jaya, Torres, Maria D., Abramowitz, Joel, Busciglio, Jorge, Gao, Yuan, Birnbaumer, Lutz, Liedtke, Wolfgang B.

“…Bisphenol A (BPA) is a ubiquitous compound that is emerging as a possible toxicant during embryonic development. BPA has been shown to epigenetically affect…”
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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain by Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.

“…TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this…”
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A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues by Nims, Robert J, Pferdehirt, Lara, Ho, Noelani B, Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K, O'Conor, Christopher J, Liedtke, Wolfgang B, Zhang, Bo, McNulty, Amy L, Guilak, Farshid

“…Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a…”
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Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion by Mannaa, Marwan, Markó, Lajos, Balogh, András, Vigolo, Emilia, N’diaye, Gabriele, Kaßmann, Mario, Michalick, Laura, Weichelt, Ulrike, Schmidt–Ott, Kai M., Liedtke, Wolfgang B., Huang, Yu, Müller, Dominik N., Kuebler, Wolfgang M., Gollasch, Maik

“…Transient receptor potential vanilloid 4 (TRPV4) cation channels are functional in all renal vascular segments and mediate endothelium-dependent…”
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Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite by Liedtke, Wolfgang B, McKinley, Michael J, Walker, Lesley L, Zhang, Hao, Pfenning, Andreas R, Drago, John, Hochendoner, Sarah J, Hilton, Donald L, Lawrence, Andrew J, Denton, Derek A

“…Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked adrenocorticotropic hormone (ACTH),…”
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Deconstructing mammalian thermoregulation by Liedtke, Wolfgang B.

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Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach by Kuebler, Wolfgang M, Jordt, Sven-Eric, Liedtke, Wolfgang B

“…Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the exponentially accelerating phase in most countries, is critically…”
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Letter to the Editor. Potential confounding variables when assessing racial disparities in outcomes after MVD for TN by CreveCoeur, Travis S., Bethamcharla, Raviteja, Gold, Michael S., Liedtke, Wolfgang B., Sekula, Raymond F.

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Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes by Savadipour, Alireza, Nims, Robert J, Rashidi, Neda, Garcia-Castorena, Jaquelin M, Tang, Ruhang, Marushack, Gabrielle K, Oswald, Sara J, Liedtke, Wolfgang B, Guilak, Farshid

“…Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the cartilage. The mechanically sensitive PIEZO ion channels…”
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Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel by Benítez‐Angeles, Miguel, Romero, Ana E. López, Llorente, Itzel, Hernández‐Araiza, Ileana, Vergara‐Jaque, Ariela, Real, Fernando H., Gutiérrez Castañeda, Óscar Eduardo, Arciniega, Marcelino, Morales‐Buenrostro, Luis E., Torres‐Quiroz, Francisco, García‐Villegas, Refugio, Tovar‐y‐Romo, Luis B., Liedtke, Wolfgang B., Islas, León D., Rosenbaum, Tamara

“…The Transient Receptor Potential Vanilloid 4 (TRPV4) channel has been shown to function in many physiological and pathophysiological processes. Despite…”
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TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour by Lindy, Amanda S., Parekh, Puja K., Zhu, Richard, Kanju, Patrick, Chintapalli, Sree V., Tsvilovskyy, Volodymyr, Patterson, Randen L., Anishkin, Andriy, van Rossum, Damian B., Liedtke, Wolfgang B.

“…Animals need to sense and react to potentially dangerous environments. TRP ion channels participate in nociception, presumably via Ca 2+ influx, in most animal…”
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Letter to the Editor. Potential confounding variables when assessing racial disparities in outcomes after MVD for TN by CreveCoeur, Travis S, Bethamcharla, Raviteja, Gold, Michael S, Liedtke, Wolfgang B, Sekula, Raymond F

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