Search Results - "Liedtke, B"

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis by Lee, Whasil, Nims, Robert J., Savadipour, Alireza, Zhang, Qiaojuan, Leddy, Holly A., Liu, Fang, McNulty, Amy L., Chen, Yong, Guilak, Farshid, Liedtke, Wolfgang B.

“…Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector, Nat. Rev…”
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Regulation of Pain and Itch by TRP Channels by Moore, Carlene, Gupta, Rupali, Jordt, Sven-Eric, Chen, Yong, Liedtke, Wolfgang B.

“…Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important…”
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TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading by O'Conor, Christopher J., Leddy, Holly A., Benefield, Halei C., Liedtke, Wolfgang B., Guilak, Farshid

“…Mechanical loading of joints plays a critical role in maintaining the health and function of articular cartilage. The mechanism(s) of chondrocyte…”
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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage by Lee, Whasil, Leddy, Holly A, Chen, Yong, Lee, Suk Hee, Zelenski, Nicole A, McNulty, Amy L, Wu, Jason, Beicker, Kellie N, Coles, Jeffrey, Zauscher, Stefan, Grandl, Jörg, Sachs, Frederick, Guilak, Farshid, Liedtke, Wolfgang B

“…Significance Cartilage, a mechanically sensitive tissue that covers joints, is essential for vertebrate locomotion by sustaining skeletal mobility…”
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TRPV4 Channels stimulate Ca²⁺-induced Ca²⁺ release in astrocytic endfeet and amplify neurovascular coupling responses by Dunn, Kathryn M., Hill-Eubanks, David C., Liedtke, Wolfgang B., Nelson, Mark T.

“…In the CNS, astrocytes are sensory and regulatory hubs that play important roles in cerebral homeostatic processes, including matching local cerebral blood…”
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch by Chen, Yong, Fang, Quan, Wang, Zilong, Zhang, Jennifer Y., MacLeod, Amanda S., Hall, Russell P., Liedtke, Wolfgang B.

“…TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to…”
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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling by Moore, Carlene, Cevikbas, Ferda, Pasolli, H Amalia, Chen, Yong, Kong, Wei, Kempkes, Cordula, Parekh, Puja, Lee, Suk Hee, Kontchou, Nelly-Ange, Yeh, Iwei, Ye, Iwei, Jokerst, Nan Marie, Fuchs, Elaine, Steinhoff, Martin, Liedtke, Wolfgang B

“…At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a…”
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Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury by Yin, Jun, Michalick, Laura, Tang, Christine, Tabuchi, Arata, Goldenberg, Neil, Dan, Qinghong, Awwad, Khader, Wang, Liming, Erfinanda, Lasti, Nouailles, Geraldine, Witzenrath, Martin, Vogelzang, Alexis, Lv, Lu, Lee, Warren L, Zhang, Haibo, Rotstein, Ori, Kapus, Andras, Szaszi, Katalin, Fleming, Ingrid, Liedtke, Wolfgang B, Kuppe, Hermann, Kuebler, Wolfgang M

“…The cation channel transient receptor potential vanilloid (TRPV) 4 is expressed in endothelial and immune cells; however, its role in acute lung injury (ALI)…”
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Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter by Yeo, Michele, Berglund, Ken, Hanna, Michael, Guo, Junjie U., Kittur, Jaya, Torres, Maria D., Abramowitz, Joel, Busciglio, Jorge, Gao, Yuan, Birnbaumer, Lutz, Liedtke, Wolfgang B.

“…Bisphenol A (BPA) is a ubiquitous compound that is emerging as a possible toxicant during embryonic development. BPA has been shown to epigenetically affect…”
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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain by Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.

“…TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this…”
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Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44–GeparQuinto) by von Minckwitz, G., Fasching, P.A., Schrader, I., Kittel, K., Huober, J., Solbach, C., Jackisch, C., Blohmer, J.U., Nekljudova, V., Gerber, B., Groh, U., Villena, C., Liedtke, B., Kittel, K., Mau, C., Potenberg, J., Schilling, J., Just, M., Bückner, U., Doering, G., Feidicker, S., Krabisch, P., Augustin, D., Nestle-Krämling, C., Rezai, M., Höß, C., Terhaag, J., Fasching, P., Staib, P., Aktas, B., Kühn, T., Khandan, F., Möbus, V., Solbach, C., Tesch, H., Stickeler, E., Heinrich, G., Wagner, H., Abdallah, A., Dewitz, T., Emons, G., Belau, A., Rethwisch, V., Lantzsch, T., Müller, V., Holms, F., Müller, T., Deuker, J.-U., Solomayer, E., Runnebaum, I., Link, H., Conrad, B., Feisel-Schwickardi, G., Steinmetz, T., Langanke, D., Ober, A., Fischer, D., Kohls, A., Weikel, W., Bischoff, J., Freese, K., Wiest, W., Sütterlin, M., Dietrich, M., Grießhammer, M., Burgmann, D.-M., Hanusch, C., Rack, B., Salat, C., Sattler, D., Tio, J., Christensen, B., Burkamp, U., Köhne, C.-H., Meinerz, W., Graßhoff, S.-T., Decker, T., Thalmann, I., Sallmann, A., Beck, T., Reimer, T., Bartzke, G., Deryal, M., Weigel, M., Huober, J., Steffens, C.-C., Lemster, S., Stefek, A., Ruhland, F., Hofmann, M., Schuster, J., Clemens, M., Fehm, T., Janni, W., Latos, K., Bauer, W., Roßmann, A., Bauer, L., Hoffmann, G., Schlag, R.

“…The GeparQuinto study showed that adding bevacizumab to 24 weeks of anthracycline–taxane–based neoadjuvant chemotherapy increases pathological complete…”
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A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues by Nims, Robert J, Pferdehirt, Lara, Ho, Noelani B, Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K, O'Conor, Christopher J, Liedtke, Wolfgang B, Zhang, Bo, McNulty, Amy L, Guilak, Farshid

“…Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a…”
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Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells by Solís-López, A, Kriebs, U, Marx, A, Mannebach, S, Liedtke, W B, Caterina, M J, Freichel, M, Tsvilovskyy, V V

“…The activation of mast cells (MC) is part of the innate and adaptive immune responses and depends on Ca2+ entry across the plasma membrane, leading to the…”
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PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin–cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer—outcome on prognosis by Untch, M., von Minckwitz, G., Konecny, G.E., Conrad, U., Fett, W., Kurzeder, C., Lück, H.-J., Stickeler, E., Urbaczyk, H., Liedtke, B., Beckmann, M.W., Salat, C., Harbeck, N., Müller, V., Schmidt, M., Hasmüller, S., Lenhard, M., Nekljudova, V., Lebeau, A., Loibl, S., Fasching, P.A.

“…The objective of this study was to compare the effect of dose-intensified neoadjuvant chemotherapy with that of standard epirubicin plus cyclophosphamide…”
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PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel and CMF versus a standard-dosed epirubicin/cyclophosphamide followed by paclitaxel±darbepoetin alfa in primary breast cancer—results at the time of surgery by Untch, M., Fasching, P.A., Konecny, G.E., von Koch, F., Conrad, U., Fett, W., Kurzeder, C., Lück, H.-J., Stickeler, E., Urbaczyk, H., Liedtke, B., Salat, C., Harbeck, N., Müller, V., Schmidt, M., Hasmüller, S., Lenhard, M., Schuster, T., Nekljudova, V., Lebeau, A., Loibl, S., von Minckwitz, G.

“…Preoperative chemotherapy is a recommended treatment of both primary operable and locally advanced breast cancer. Strategies to improve efficacy include the…”
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Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion by Mannaa, Marwan, Markó, Lajos, Balogh, András, Vigolo, Emilia, N’diaye, Gabriele, Kaßmann, Mario, Michalick, Laura, Weichelt, Ulrike, Schmidt–Ott, Kai M., Liedtke, Wolfgang B., Huang, Yu, Müller, Dominik N., Kuebler, Wolfgang M., Gollasch, Maik

“…Transient receptor potential vanilloid 4 (TRPV4) cation channels are functional in all renal vascular segments and mediate endothelium-dependent…”
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Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite by Liedtke, Wolfgang B, McKinley, Michael J, Walker, Lesley L, Zhang, Hao, Pfenning, Andreas R, Drago, John, Hochendoner, Sarah J, Hilton, Donald L, Lawrence, Andrew J, Denton, Derek A

“…Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked adrenocorticotropic hormone (ACTH),…”
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Deconstructing mammalian thermoregulation by Liedtke, Wolfgang B.

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Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach by Kuebler, Wolfgang M, Jordt, Sven-Eric, Liedtke, Wolfgang B

“…Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the exponentially accelerating phase in most countries, is critically…”
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Letter to the Editor. Potential confounding variables when assessing racial disparities in outcomes after MVD for TN by CreveCoeur, Travis S., Bethamcharla, Raviteja, Gold, Michael S., Liedtke, Wolfgang B., Sekula, Raymond F.

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