Search Results - "Lieberman, Nicole"

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age by Lieberman, Nicole A P, Peddu, Vikas, Xie, Hong, Shrestha, Lasata, Huang, Meei-Li, Mears, Megan C, Cajimat, Maria N, Bente, Dennis A, Shi, Pei-Yong, Bovier, Francesca, Roychoudhury, Pavitra, Jerome, Keith R, Moscona, Anne, Porotto, Matteo, Greninger, Alexander L

“…Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a wide range of clinical manifestations in different…”
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Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection by Ferren, Marion, Favède, Valérie, Decimo, Didier, Iampietro, Mathieu, Lieberman, Nicole A. P., Weickert, Jean-Luc, Pelissier, Rodolphe, Mazelier, Magalie, Terrier, Olivier, Moscona, Anne, Porotto, Matteo, Greninger, Alexander L., Messaddeq, Nadia, Horvat, Branka, Mathieu, Cyrille

“…SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also…”
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SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98 by Addetia, Amin, Lieberman, Nicole A P, Phung, Quynh, Hsiang, Tien-Ying, Xie, Hong, Roychoudhury, Pavitra, Shrestha, Lasata, Loprieno, Michelle A, Huang, Meei-Li, Gale, Jr, Michael, Jerome, Keith R, Greninger, Alexander L

“…RNA viruses that replicate in the cytoplasm often disrupt nucleocytoplasmic transport to preferentially translate their own transcripts and prevent host…”
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Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis by Romeis, Emily, Lieberman, Nicole A P, Molini, Barbara, Tantalo, Lauren C, Chung, Benjamin, Phung, Quynh, Avendaño, Carlos, Vorobieva, Anastassia, Greninger, Alexander L, Giacani, Lorenzo

“…The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions…”
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Relapsing Fever Caused by Borrelia lonestari after Tick Bite in Alabama, USA by Vazquez Guillamet, Laia J, Marx, Grace E, Benjamin, William, Pappas, Peter, Lieberman, Nicole A P, Bachiashvili, Kimo, Leal, Sixto, Lieberman, Joshua A

“…We report an immunocompromised patient in Alabama, USA, 75 years of age, with relapsing fevers and pancytopenia who had spirochetemia after a tick bite. We…”
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Genomic Analysis of Early Monkeypox Virus Outbreak Strains, Washington, USA by Roychoudhury, Pavitra, Sereewit, Jaydee, Xie, Hong, Nunley, Ethan, Bakhash, Shah M, Lieberman, Nicole A P, Greninger, Alexander L

“…We conducted a genomic analysis of monkeypox virus sequences collected early in the 2022 outbreak, during July-August , in Washington, USA. Using 109 viral…”
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Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure by Lin, Michelle J, Haynes, Austin M, Addetia, Amin, Lieberman, Nicole A P, Phung, Quynh, Xie, Hong, Nguyen, Tien V, Molini, Barbara J, Lukehart, Sheila A, Giacani, Lorenzo, Greninger, Alexander L

“…Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK…”
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Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain by Mathieu, Cyrille, Bovier, Francesca T, Ferren, Marion, Lieberman, Nicole A P, Predella, Camilla, Lalande, Alexandre, Peddu, Vikas, Lin, Michelle J, Addetia, Amin, Patel, Achchhe, Outlaw, Victor, Corneo, Barbara, Dorrello, N Valerio, Briese, Thomas, Hardie, Diana, Horvat, Branka, Moscona, Anne, Greninger, Alexander L, Porotto, Matteo

“…Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)-L454W-was isolated from two patients who died of MeV central nervous system…”
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Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy by Moyes, Kara W, Lieberman, Nicole A P, Kreuser, Shannon A, Chinn, Harrison, Winter, Conrad, Deutsch, Gail, Hoglund, Virginia, Watson, Reid, Crane, Courtney A

“…In spite of their successes against hematologic malignancies, immunotherapeutic interventions for the treatment of patients with glioblastoma (GBM) have thus…”
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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models by Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.

“…Therapeutic options against SARS-CoV-2 are underutilized. Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), have received emergency use…”
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Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy by Lieberman, Nicole A P, DeGolier, Kole, Kovar, Heather M, Davis, Amira, Hoglund, Virginia, Stevens, Jeffrey, Winter, Conrad, Deutsch, Gail, Furlan, Scott N, Vitanza, Nicholas A, Leary, Sarah E S, Crane, Courtney A

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal CNS tumor diagnosed in 300 American children per year. Radiation is the only…”
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Whole Genome Sequence of a Treponema pallidum Strain From a Formalin-Fixed, Paraffin-Embedded Fine Needle Aspirate of a Cervical Lymph Node by Aldrete, Sol, Kroft, Steven H., Romeis, Emily, Lieberman, Nicole A. P., Greninger, Alexander L., Giacani, Lorenzo, Kron, Michael A.

“…A patient with unilateral cervical lymphadenopathy suspicious for malignancy underwent a fine needle aspiration. Histology demonstrated mixed inflammatory…”
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Clinical Performance and Trends during the First Two Months of Monkeypox Virus PCR Testing at Two United States Reference Labs by Lieberman, Nicole A P, Mathias, Patrick C, Bradley, Benjamin T, Greninger, Alexander L

“…Recently, a sustained human-to-human outbreak of monkeypox virus (MPXV), a member of the genus, which includes the etiologic agent of smallpox, has been…”
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Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain by Outlaw, Victor K, Bovier, Francesca T, Mears, Megan C, Cajimat, Maria N, Zhu, Yun, Lin, Michelle J, Addetia, Amin, Lieberman, Nicole A P, Peddu, Vikas, Xie, Xuping, Shi, Pei-Yong, Greninger, Alexander L, Gellman, Samuel H, Bente, Dennis A, Moscona, Anne, Porotto, Matteo

“…The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of the 2019 coronavirus disease (COVID-19), has…”
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Genomic Epidemiology of Treponema pallidum and Circulation of Strains With Diminished tprK Antigen Variation Capability in Seattle, 2021–2022 by Lieberman, Nicole A P, Avendaño, Carlos C, Bakhash, Shah A K Mohamed, Nunley, Ethan, Xie, Hong, Giacani, Lorenzo, Berzkalns, Anna, Soge, Olusegun O, Reid, Tara B, Golden, Matthew R, Greninger, Alexander L

“…Abstract Background The incidence of syphilis continues to increase in the United States, yet little is known about Treponema pallidum genomic epidemiology…”
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Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19 by Lin, Michelle J., Rachleff, Victoria M., Xie, Hong, Shrestha, Lasata, Lieberman, Nicole A. P., Peddu, Vikas, Addetia, Amin, Casto, Amanda M., Breit, Nathan, Mathias, Patrick C., Huang, Meei-Li, Jerome, Keith R., Greninger, Alexander L., Roychoudhury, Pavitra

“…Rapid dissemination of SARS-CoV-2 sequencing data to public repositories has enabled widespread study of viral genomes, but studies of longitudinal specimens…”
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Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete by Romeis, Emily, Tantalo, Lauren, Lieberman, Nicole, Phung, Quynh, Greninger, Alex, Giacani, Lorenzo

“…Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum ( T . pallidum ), the causative agent of syphilis, has not…”
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ORF-Interrupting Mutations in Monkeypox Virus Genomes from Washington and Ohio, 2022 by Sereewit, Jaydee, Lieberman, Nicole A P, Xie, Hong, Bakhash, Shah A K Mohamed, Nunley, B Ethan, Chung, Benjamin, Mills, Margaret G, Roychoudhury, Pavitra, Greninger, Alexander L

“…Monkeypox virus, the causative agent of the 2022 monkeypox outbreak, is a double-stranded DNA virus in the genus of the family. Genes in terminal regions of…”
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Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models by Vitanza, Nicholas A, Biery, Matt C, Myers, Carrie, Ferguson, Eric, Zheng, Ye, Girard, Emily J, Przystal, Justyna M, Park, Giulia, Noll, Alyssa, Pakiam, Fiona, Winter, Conrad A, Morris, Shelli M, Sarthy, Jay, Cole, Bonnie L, Leary, Sarah E S, Crane, Courtney, Lieberman, Nicole A P, Mueller, Sabine, Nazarian, Javad, Gottardo, Raphael, Brusniak, Mi-Youn, Mhyre, Andrew J, Olson, James M

“…Abstract Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), have a dismal prognosis, with less than 2% surviving 5…”
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Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays by Mills, Margaret G., Juergens, Kate B., Gov, Jolene P., McCormick, Carter J., Sampoleo, Reigran, Kachikis, Alisa, Amory, John K., Fang, Ferric C., Pérez-Osorio, Ailyn C., Lieberman, Nicole A.P., Greninger, Alexander L.

“…•MPXV qPCR assays targeting G2R and F3L have limits of detection at 66 copies/mL for virus in VTM.•MPXV-G2R gives slightly lower Ct values than F3L, likely…”
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