Search Results - "Lieber, R"

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway by Lieber, Michael R

“…Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and…”
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Mechanisms of human lymphoid chromosomal translocations by Lieber, Michael R.

“…Key Points Neoplastic chromosomal translocations (and other pathological chromosomal rearrangements) can be considered in terms of a breakage phase, in which…”
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The molecular basis and disease relevance of non-homologous DNA end joining by Zhao, Bailin, Rothenberg, Eli, Ramsden, Dale A., Lieber, Michael R.

“…Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type of DNA double-strand break (DSB) during most of the cell cycle and is…”
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The Mechanism of Human Nonhomologous DNA End Joining by Lieber, Michael R.

“…Double-strand breaks are common in all living cells, and there are two major pathways for their repair. In eukaryotes, homologous recombination is restricted…”
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Non-homologous DNA end joining and alternative pathways to double-strand break repair by Chang, Howard H. Y., Pannunzio, Nicholas R., Adachi, Noritaka, Lieber, Michael R.

“…Key Points Mammalian non-homologous DNA end joining (NHEJ) is the primary pathway for the repair of DNA double-strand breaks (DSBs) throughout the cell cycle,…”
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Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018 by Peery, Anne F., Crockett, Seth D., Murphy, Caitlin C., Lund, Jennifer L., Dellon, Evan S., Williams, J. Lucas, Jensen, Elizabeth T., Shaheen, Nicholas J., Barritt, Alfred S., Lieber, Sarah R., Kochar, Bharati, Barnes, Edward L., Fan, Y. Claire, Pate, Virginia, Galanko, Joseph, Baron, Todd H., Sandler, Robert S.

“…Estimates of disease burden can inform national health priorities for research, clinical care, and policy. We aimed to estimate health care use and spending…”
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The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis by Zhao, Bailin, Watanabe, Go, Morten, Michael J., Reid, Dylan A., Rothenberg, Eli, Lieber, Michael R.

“…One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how the two free DNA ends are brought together — a step called…”
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NHEJ and its backup pathways in chromosomal translocations by Lieber, Michael R

“…Two recent papers break major new ground on the issues of NHEJ, backup pathways for NHEJ and how these relate to the chromosomal translocation process…”
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Mechanism and regulation of human non-homologous DNA end-joining by Lieber, Michael R, Schwarz, Klaus, Ma, Yunmei, Pannicke, Ulrich

“…Non-homologous DNA end-joining (NHEJ)--the main pathway for repairing double-stranded DNA breaks--functions throughout the cell cycle to repair such lesions…”
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G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter by Roy, Deepankar, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination by Ma, Yunmei, Pannicke, Ulrich, Schwarz, Klaus, Lieber, Michael R.

“…Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B and T lymphocytes…”
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Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia by Swaminathan, Srividya, Klemm, Lars, Park, Eugene, Papaemmanuil, Elli, Ford, Anthony, Kweon, Soo-Mi, Trageser, Daniel, Hasselfeld, Brian, Henke, Nadine, Mooster, Jana, Geng, Huimin, Schwarz, Klaus, Kogan, Scott C, Casellas, Rafael, Schatz, David G, Lieber, Michael R, Greaves, Mel F, Müschen, Markus

“…Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6 - RUNX1 translocations. Müschen and colleagues show that repeated…”
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Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair by Reid, Dylan A., Keegan, Sarah, Leo-Macias, Alejandra, Watanabe, Go, Strande, Natasha T., Chang, Howard H., Oksuz, Betul Akgol, Fenyo, David, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli

“…Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand breaks (DSBs), involving synapsis and ligation of the broken strands. We…”
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Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency by Chang, Howard H.Y., Watanabe, Go, Gerodimos, Christina A., Ochi, Takashi, Blundell, Tom L., Jackson, Stephen P., Lieber, Michael R.

“…The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model,…”
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Concept of DNA Lesion Longevity and Chromosomal Translocations by Pannunzio, Nicholas R., Lieber, Michael R.

“…A subset of chromosomal translocations related to B cell malignancy in human patients arises due to DNA breaks occurring within defined 20–600 base pair (bp)…”
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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells by Lieber, Michael R, Yu, Kefei, Chedin, Frederic, Hsieh, Chih-Lin, Wilson, Thomas E

“…The mechanism responsible for immunoglobulin class switch recombination is unknown. Previous work has shown that class switch sequences have the unusual…”
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A nonlinear model of passive muscle viscosity by Meyer, G A, McCulloch, A D, Lieber, R L

“…The material properties of passive skeletal muscle are critical to proper function and are frequently a target for therapeutic and interventional strategies…”
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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization by Jeong, Soo Lim, Zhang, Hongyu, Yamaki, Shanni, Yang, Chenyu, McKemy, David D, Lieber, Michael R, Pham, Phuong, Goodman, Myron F

“…We describe a purified biochemical system to produce monoclonal antibodies (Abs) in vitro using activation-induced deoxycytidine deaminase (AID) and DNA…”
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Mechanism of R-Loop Formation at Immunoglobulin Class Switch Sequences by Roy, Deepankar, Yu, Kefei, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mechanisms of chromosomal rearrangement in the human genome by Tsai, Albert G, Lieber, Michael R

“…Many human cancers are associated with characteristic chromosomal rearrangements, especially hematopoietic cancers such as leukemias and lymphomas. The first…”
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