Search Results - "Lieber, Michael R"

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway by Lieber, Michael R

“…Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and…”
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Mechanisms of human lymphoid chromosomal translocations by Lieber, Michael R.

“…Key Points Neoplastic chromosomal translocations (and other pathological chromosomal rearrangements) can be considered in terms of a breakage phase, in which…”
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The molecular basis and disease relevance of non-homologous DNA end joining by Zhao, Bailin, Rothenberg, Eli, Ramsden, Dale A., Lieber, Michael R.

“…Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type of DNA double-strand break (DSB) during most of the cell cycle and is…”
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The Mechanism of Human Nonhomologous DNA End Joining by Lieber, Michael R.

“…Double-strand breaks are common in all living cells, and there are two major pathways for their repair. In eukaryotes, homologous recombination is restricted…”
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Non-homologous DNA end joining and alternative pathways to double-strand break repair by Chang, Howard H. Y., Pannunzio, Nicholas R., Adachi, Noritaka, Lieber, Michael R.

“…Key Points Mammalian non-homologous DNA end joining (NHEJ) is the primary pathway for the repair of DNA double-strand breaks (DSBs) throughout the cell cycle,…”
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The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis by Zhao, Bailin, Watanabe, Go, Morten, Michael J., Reid, Dylan A., Rothenberg, Eli, Lieber, Michael R.

“…One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how the two free DNA ends are brought together — a step called…”
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NHEJ and its backup pathways in chromosomal translocations by Lieber, Michael R

“…Two recent papers break major new ground on the issues of NHEJ, backup pathways for NHEJ and how these relate to the chromosomal translocation process…”
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G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter by Roy, Deepankar, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia by Swaminathan, Srividya, Klemm, Lars, Park, Eugene, Papaemmanuil, Elli, Ford, Anthony, Kweon, Soo-Mi, Trageser, Daniel, Hasselfeld, Brian, Henke, Nadine, Mooster, Jana, Geng, Huimin, Schwarz, Klaus, Kogan, Scott C, Casellas, Rafael, Schatz, David G, Lieber, Michael R, Greaves, Mel F, Müschen, Markus

“…Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6 - RUNX1 translocations. Müschen and colleagues show that repeated…”
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Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair by Reid, Dylan A., Keegan, Sarah, Leo-Macias, Alejandra, Watanabe, Go, Strande, Natasha T., Chang, Howard H., Oksuz, Betul Akgol, Fenyo, David, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli

“…Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand breaks (DSBs), involving synapsis and ligation of the broken strands. We…”
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Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency by Chang, Howard H.Y., Watanabe, Go, Gerodimos, Christina A., Ochi, Takashi, Blundell, Tom L., Jackson, Stephen P., Lieber, Michael R.

“…The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model,…”
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Concept of DNA Lesion Longevity and Chromosomal Translocations by Pannunzio, Nicholas R., Lieber, Michael R.

“…A subset of chromosomal translocations related to B cell malignancy in human patients arises due to DNA breaks occurring within defined 20–600 base pair (bp)…”
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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization by Jeong, Soo Lim, Zhang, Hongyu, Yamaki, Shanni, Yang, Chenyu, McKemy, David D, Lieber, Michael R, Pham, Phuong, Goodman, Myron F

“…We describe a purified biochemical system to produce monoclonal antibodies (Abs) in vitro using activation-induced deoxycytidine deaminase (AID) and DNA…”
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Mechanism of R-Loop Formation at Immunoglobulin Class Switch Sequences by Roy, Deepankar, Yu, Kefei, Lieber, Michael R.

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Mechanism and regulation of human non-homologous DNA end-joining by Lieber, Michael R, Schwarz, Klaus, Ma, Yunmei, Pannicke, Ulrich

“…Non-homologous DNA end-joining (NHEJ)--the main pathway for repairing double-stranded DNA breaks--functions throughout the cell cycle to repair such lesions…”
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Mechanisms of chromosomal rearrangement in the human genome by Tsai, Albert G, Lieber, Michael R

“…Many human cancers are associated with characteristic chromosomal rearrangements, especially hematopoietic cancers such as leukemias and lymphomas. The first…”
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Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability by Pannunzio, Nicholas R., Lieber, Michael R.

“…The interplay of transcription, topological tension, and chromosome breakage is a subject of intense interest, but, with so many facets to the problem, it is…”
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DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining by Conlin, Michael P., Reid, Dylan A., Small, George W., Chang, Howard H., Watanabe, Go, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli

“…Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here, we investigate the mechanistic basis for this…”
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H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations by Shimazaki, Noriko, Tsai, Albert G., Lieber, Michael R.

“…The PHD finger of the RAG2 polypeptide of the RAG1/RAG2 complex binds to the histone H3 modification, trimethylated lysine 4 (H3K4me3), and in some manner…”
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Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies by Liu, Di, Loh, Yong-Hwee Eddie, Hsieh, Chih-Lin, Lieber, Michael R.

“…Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites…”
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