Search Results - "Lieber, C S"

Cytochrome P-4502E1: its physiological and pathological role by Lieber, C S

“…The role of the microsomal ethanol-oxidizing system (MEOS) in hepatic ethanol metabolism is reviewed, with focus on its constitutive, ethanol-inducible…”
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Alcohol : Its metabolism and interaction with nutrients by LIEBER, C. S

“…In the past, alcoholic liver disease was attributed exclusively to dietary deficiencies, but experimental and judicious clinical studies have now established…”
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Microsomal ethanol-oxidizing system (MEOS) : The first 30 years (1968-1998) : A review by LIEBER, C. S

“…Oxidation of ethanol via alcohol dehydrogenase (ADH) explains various metabolic effects of ethanol but does not account for the tolerance and a number of…”
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Alcohol and the liver: 1994 update by Lieber, C S

“…This article reviews current concepts on the pathogenesis and treatment of alcoholic liver disease. It has been known that the hepatotoxicity of ethanol…”
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Alcohol, vitamin A, and β-carotene : adverse interactions, including hepatotoxicity and carcinogenicity by LEO, M. A, LIEBER, C. S

“…Isozymes of alcohol and other dehydrogenases convert ethanol and retinol to their corresponding aldehydes in vitro. In addition, new pathways of retinol…”
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Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts by Yan, L., Ge, H., Li, H., Lieber, S.C., Natividad, F., Resuello, R.R.G., Kim, S.-J., Akeju, S., Sun, A., Loo, K., Peppas, A.P., Rossi, F., Lewandowski, E.D., Thomas, A.P., Vatner, S.F., Vatner, D.E.

“…We utilized proteomic techniques in a primate model ( Macaca fascicularis) of aging to determine potential mechanisms to explain gender differences in…”
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Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis by Lieber, Charles S.

“…Liver disease in the alcoholic is due not only to malnutrition but also to ethanol's hepatotoxicity linked to its metabolism by means of the alcohol…”
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Hepatic, metabolic and toxic effects of ethanol: 1991 update by Lieber, C S

“…Until two decades ago, dietary deficiencies were considered to be the only reason for alcoholics to develop liver disease. As the overall nutrition of the…”
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Ethanol and lipid metabolism by Feinman, L, Lieber, C S

“…Feinman and Lieber discuss Siler et al's report that low-dose ethanol consumption in healthy volunteers modestly activates hepatic de novo lipogenesis. Their…”
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Mechanism of ethanol induced hepatic injury by Lieber, C S

“…Ethanol is hepatotoxic through redox changes produced by the NADH generated in its oxidation via the alcohol dehydrogenase pathway, which in turn affects the…”
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Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2 by Raucy, J L, Lasker, J M, Lieber, C S, Black, M

“…Acetaminophen (APAP), a widely used over-the-counter analgesic, is known to cause hepatotoxicity when ingested in large quantities in both animals and man,…”
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Models of Alcoholic Liver Disease in Rodents: A Critical Evaluation by Hall, Pauline de la M., Lieber, Charles S., DeCarli, Leonore M., French, Samuel W., Lindros, Kai O., Järveläinen, Harri, Bode, Christiane, Parlesak, Alexandr, Bode, J. Christian

“…This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were J. Christian Bode and Hiroshi Fukui. The…”
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Prevention and Treatment of Liver Fibrosis Based on Pathogenesis by Lieber, Charles S.

“…Multiple agents have been proposed for the prevention and treatment of fibrosis. S‐adenosylmethionine was reported to oppose CC14,‐induced fibrosis in the rat,…”
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Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis by Aleynik, Semyon I., Leo, Maria Anna, Ma, Xiaoli, Aleynik, Maria K., Lieber, Charles S.

“…Background/Aims: Polyenylphosphatidylcholine protects against alcoholic cirrhosis in the baboon and carbon tetrachloride-induced cirrhosis in rats. This study…”
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Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system by SALMELA, K. S, KESSOVA, I. G, TSYRLOV, I. B, LIEBER, C. S

“…The microsomal ethanol oxidizing system comprises an ethanol-inducible cytochrome P-4502E1, but the involvement of other P-450s has also been suggested. In our…”
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Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon by Lieber, C S, Robins, S J, Li, J, DeCarli, L M, Mak, K M, Fasulo, J M, Leo, M A

“…Polyunsaturated soybean lecithin (55%-60% phosphatidylcholine [PC]) protects against fibrosis in alcohol-fed baboons. The present study was undertaken to…”
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Alcoholic liver injury: pathogenesis and therapy in 2001 by Lieber, C S

“…Much progress has been made in the understanding of the pathogenesis of alcoholic liver disease, resulting in improvement of prevention and promising prospects…”
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Hepatic, Metabolic, and Nutritional Disorders of Alcoholism: From Pathogenesis to Therapy by Lieber, Charles S.

“…Much progress has been made in the understanding of the pathogenesis of alcoholic liver disease, resulting in an improvement in treatment. Nutritional…”
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Ethnic differences in gastric sigma-alcohol dehydrogenase activity and ethanol first-pass metabolism by Dohmen, K, Baraona, E, Ishibashi, H, Pozzato, G, Moretti, M, Matsunaga, C, Fujimoto, K, Lieber, C S

“…We assessed whether the low sigma-alcohol dehydrogenase (ADH) activity in Japanese (compared with Caucasians) affects the first-pass metabolism of ethanol. ADH…”
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Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases by Lieber, C S

“…The main pathway for the hepatic oxidation of ethanol to acetaldehyde proceeds via ADH and is associated with the reduction of NAD to NADH; the latter produces…”
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