Search Results - "Liebelt, Frauke"

Ubiquitin-dependent and independent roles of SUMO in proteostasis by Liebelt, Frauke, Vertegaal, Alfred C O

“…Cellular proteomes are continuously undergoing alterations as a result of new production of proteins, protein folding, and degradation of proteins. The proper…”
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The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation by Liebelt, Frauke, Jansen, Nicolette S., Kumar, Sumit, Gracheva, Ekaterina, Claessens, Laura A., Verlaan-de Vries, Matty, Willemstein, Edwin, Vertegaal, Alfred C. O.

“…In contrast to our extensive knowledge on ubiquitin polymer signaling, we are severely limited in our understanding of poly-SUMO signaling. We set out to…”
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Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases by Mulder, Monique P. C., Merkx, Remco, Witting, Katharina F., Hameed, Dharjath S., El Atmioui, Dris, Lelieveld, Lindsey, Liebelt, Frauke, Neefjes, Jacques, Berlin, Ilana, Vertegaal, Alfred C. O., Ovaa, Huib

“…SUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific…”
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Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation by Liebelt, Frauke, Schimmel, Joost, Verlaan – de Vries, Matty, Klemann, Esra, van Royen, Martin E, van der Weegen, Yana, Luijsterburg, Martijn S, Mullenders, Leon H, Pines, Alex, Vermeulen, Wim, Vertegaal, Alfred C O

“…Abstract Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB…”
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Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis by van IJzendoorn, David G.P., Forghany, Zary, Liebelt, Frauke, Vertegaal, Alfred C., Jochemsen, Aart G., Bovée, Judith V.M.G., Szuhai, Karoly, Baker, David A.

“…Epithelioid hemangioma is a locally aggressive vascular neoplasm, found in bones and soft tissue, whose cause is currently unknown, but may involve oncogene…”
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SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock by Liebelt, Frauke, Sebastian, Rebecca M., Moore, Christopher L., Mulder, Monique P.C., Ovaa, Huib, Shoulders, Matthew D., Vertegaal, Alfred C.O.

“…The role of stress-induced increases in SUMO2/3 conjugation during the heat shock response (HSR) has remained enigmatic. We investigated SUMO signal…”
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Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases by Mulder, Monique P. C., Merkx, Remco, Witting, Katharina F., Hameed, Dharjath S., El Atmioui, Dris, Lelieveld, Lindsey, Liebelt, Frauke, Neefjes, Jacques, Berlin, Ilana, Vertegaal, Alfred C. O., Ovaa, Huib

“…SUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific…”
Get full text