Search Results - "Lidke, Diane S."

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics by Freed, Daniel M., Bessman, Nicholas J., Kiyatkin, Anatoly, Salazar-Cavazos, Emanuel, Byrne, Patrick O., Moore, Jason O., Valley, Christopher C., Ferguson, Kathryn M., Leahy, Daniel J., Lidke, Diane S., Lemmon, Mark A.

“…Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct…”
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Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement by Freeman, Spencer A., Vega, Anthony, Riedl, Magdalena, Collins, Richard F., Ostrowski, Phillip P., Woods, Elliot C., Bertozzi, Carolyn R., Tammi, Markku I., Lidke, Diane S., Johnson, Pauline, Mayor, Satyajit, Jaqaman, Khuloud, Grinstein, Sergio

“…Phagocytic receptors must diffuse laterally to become activated upon clustering by multivalent targets. Receptor diffusion, however, can be obstructed by…”
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Integrin activation is an essential component of SARS-CoV-2 infection by Simons, Peter, Rinaldi, Derek A., Bondu, Virginie, Kell, Alison M., Bradfute, Steven, Lidke, Diane S., Buranda, Tione

“…SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that…”
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Advances in high-resolution imaging--techniques for three-dimensional imaging of cellular structures by Lidke, Diane S, Lidke, Keith A

“…A fundamental goal in biology is to determine how cellular organization is coupled to function. To achieve this goal, a better understanding of organelle…”
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Sequential superresolution imaging of multiple targets using a single fluorophore by Valley, Christopher C, Liu, Sheng, Lidke, Diane S, Lidke, Keith A

“…Fluorescence superresolution (SR) microscopy, or fluorescence nanoscopy, provides nanometer scale detail of cellular structures and allows for imaging of…”
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Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope by Cutler, Patrick J, Malik, Michael D, Liu, Sheng, Byars, Jason M, Lidke, Diane S, Lidke, Keith A

“…Many cellular signaling processes are initiated by dimerization or oligomerization of membrane proteins. However, since the spatial scale of these interactions…”
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ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding by Lidke, Diane S, Low-Nam, Shalini T, Lidke, Keith A, Cutler, Patrick J, Roovers, Rob C, van Bergen en Henegouwen, Paul M P, Wilson, Bridget S

“…Dimerization, ligand-binding and co-confinement are all expected to contribute to erbB1 signaling, but the level of their contribution has not yet been fully…”
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Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy by Dibaji, Hassan, Kazemi Nasaban Shotorban, Ali, Grattan, Rachel M., Lucero, Shayna, Schodt, David J., Lidke, Keith A., Petruccelli, Jonathan, Lidke, Diane S., Liu, Sheng, Chakraborty, Tonmoy

“…Rapid, high-resolution volumetric imaging without moving heavy objectives or disturbing delicate samples remains challenging. Pupil-matched remote focusing…”
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erbB3 Is an Active Tyrosine Kinase Capable of Homo- and Heterointeractions by Steinkamp, Mara P., Low-Nam, Shalini T., Yang, Shujie, Lidke, Keith A., Lidke, Diane S., Wilson, Bridget S.

“…Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer by Valley, Christopher C, Arndt-Jovin, Donna J, Karedla, Narain, Steinkamp, Mara P, Chizhik, Alexey I, Hlavacek, William S, Wilson, Bridget S, Lidke, Keith A, Lidke, Diane S

“…Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that…”
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High-precision estimation of emitter positions using Bayesian grouping of localizations by Fazel, Mohamadreza, Wester, Michael J., Schodt, David J., Cruz, Sebastian Restrepo, Strauss, Sebastian, Schueder, Florian, Schlichthaerle, Thomas, Gillette, Jennifer M., Lidke, Diane S., Rieger, Bernd, Jungmann, Ralf, Lidke, Keith A.

“…Single-molecule localization microscopy super-resolution methods rely on stochastic blinking/binding events, which often occur multiple times from each emitter…”
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Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules by Vleeshouwers, Ward, van den Dries, Koen, de Keijzer, Sandra, Joosten, Ben, Lidke, Diane S, Cambi, Alessandra

“…Prostaglandin E2 (PGE2) is a lipid mediator that modulates the function of myeloid immune cells such as macrophages and dendritic cells (DCs) through the…”
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PD-L1 Expression in Mastocytosis by Williams, Margaret, Lidke, Diane S, Hartmann, Karin, George, Tracy I

“…Programmed death 1 (PD-1), when activated by its ligands PD-L1 and PD-L2, suppresses active immune cells in normal immune regulation to limit autoimmunity and,…”
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Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression by Lund, Troy C, Kobs, Amanda J, Kramer, Ashley, Nyquist, Mick, Kuroki, Marcos T, Osborn, John, Lidke, Diane S, Low-Nam, Shalini T, Blazar, Bruce R, Tolar, Jakub

“…The ability of cells to detect changes in the microenvironment is important in cell signaling and responsiveness to environmental fluctuations. Our interest is…”
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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes by Mudumbi, Krishna C., Burns, Eric A., Schodt, David J., Petrova, Zaritza O., Kiyatkin, Anatoly, Kim, Lucy W., Mangiacapre, Emma M., Ortiz-Caraveo, Irais, Rivera Ortiz, Hector, Hu, Chun, Ashtekar, Kumar D., Lidke, Keith A., Lidke, Diane S., Lemmon, Mark A.

“…The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other…”
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Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM by Coban, Oana, Zanetti-Dominguez, Laura C., Matthews, Daniel R., Rolfe, Daniel J., Weitsman, Gregory, Barber, Paul R., Barbeau, Jody, Devauges, Viviane, Kampmeier, Florian, Winn, Martyn, Vojnovic, Borivoj, Parker, Peter J., Lidke, Keith A., Lidke, Diane S., Ameer-Beg, Simon M., Martin-Fernandez, Marisa L., Ng, Tony

“…Deregulation of epidermal growth factor receptor (EGFR) signaling has been correlated with the development of a variety of human carcinomas. EGF-induced…”
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Sequential super-resolution imaging using DNA strand displacement by Pallikkuth, Sandeep, Martin, Cheyenne, Farzam, Farzin, Edwards, Jeremy S, Lakin, Matthew R, Lidke, Diane S, Lidke, Keith A

“…Sequential labeling and imaging in fluorescence microscopy allows the imaging of multiple structures in the same cell using a single fluorophore species. In…”
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ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation by Lidke, Diane S., Huang, Fang, Post, Janine N., Rieger, Bernd, Wilsbacher, Julie, Thomas, James L., Pouysségur, Jacques, Jovin, Thomas M., Lenormand, Philippe

“…Upon activation, ERKs translocate from the cytoplasm to the nucleus. This process is required for the induction of many cellular responses, yet the molecular…”
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Localization Microscopy using Noncovalent Fluorogen Activation by Genetically Encoded Fluorogen-Activating Proteins by Yan, Qi, Schwartz, Samantha L., Maji, Suvrajit, Huang, Fang, Szent-Gyorgyi, Chris, Lidke, Diane S., Lidke, Keith A., Bruchez, Marcel P.

“…The noncovalent equilibrium activation of a fluorogenic malachite green dye and its cognate fluorogen‐activating protein (FAP) can produce a sparse labeling…”
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Mast cell synapses and exosomes: membrane contacts for information exchange by Carroll-Portillo, Amanda, Surviladze, Zurab, Cambi, Alessandra, Lidke, Diane S, Wilson, Bridget S

“…In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease. In this…”
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